Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death. It is a derivative of camptothecin. Irinotecan was approved for the treatment of advanced pancreatic cancer in October, 2015 (irinotecan liposome injection, trade name Onivyde).
For the treatment of metastatic colorectal cancer (first-line therapy when administered with 5-fluorouracil and leucovorin). Also used in combination with cisplatin for the treatment of extensive small cell lung cancer. Irinotecan is currently under investigation for the treatment of metastatic or recurrent cervical cancer. Also used in combination with fluorouracil and leucovorin for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy.
Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China
USA Health Strada Patient Care Center, Mobile, Alabama, United States
Mercy Hospital Saint Louis, Saint Louis, Missouri, United States
Children's Hospital of Alabama, Birmingham, Alabama, United States
First Hospital of China Medical University, Shenyang, Liaoning, China
Zhongshan Hospital, Shanghai, Shanghai, China
Shanghai East Hospital, Shanghai, Shanghai, China
Highlands Oncology Group, PA /ID# 259424, Springdale, Arkansas, United States
City of Hope National Medical Center /ID# 257576, Duarte, California, United States
Northwestern University Robert H. Lurie Comprehensive Cancer Center /ID# 260563, Chicago, Illinois, United States
GenesisCare North Shore, Sydney, New South Wales, Australia
Wollongong Hospital, Wollongong, New South Wales, Australia
Warringal Private Hospital, Melbourne, Victoria, Australia
Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States
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