Nitric Oxide

Generic Name: Nitric Oxide

Brand Names: Inomax, Kinox, Noxivent, INOmax

Drug Type: Small Molecule

Chemical Formula: NO

CAS Number: 10102-43-9

Unique Ingredient Identifier: 31C4KY9ESH

Background: Nitric oxide or Nitrogen monoxide is a chemical compound with chemical formula NO. This gas is an important signaling molecule in the body of mammals including humans and is an extremely important intermediate in the chemical industry. It is also a toxic air pollutant produced by automobile engines and power plants.
...

Indication: For the treatment of term and near-term (>34 weeks) neonates with hypoxic respiratory failure

Associated Conditions: Hypoxic Respiratory Failure

Associated Therapies: -

Clinical Trials

Role of the Nitric Oxide (NO) in Pre-oxygenation Before Anesthetic Induction in Patients With a Pulmonary Hypertension in Cardiac Surgery. Pilot Study of Feasibility

Phase 2

Conditions: Pulmonary Hypertension

Interventions: Drug: Nitric oxide

First Posted Date: 2015-01-26

Last Posted Date: 2019-02-04

Lead Sponsor: University Hospital, Clermont-Ferrand

Target Recruit Count: 30

Registration Number: NCT02345616

Locations: 🇫🇷
CHU de Clermont-Ferrand, Clermont-Ferrand, France

RATNO, Reducing Antibiotic Tolerance Using Nitric Oxide in CF - a Phase 2 Pilot Study

Phase 2

Completed

Conditions: Cystic Fibrosis

Interventions: Drug: Control
Drug: Nitric Oxide

First Posted Date: 2014-11-20

Last Posted Date: 2024-05-30

Lead Sponsor: University Hospital Southampton NHS Foundation Trust

Target Recruit Count: 12

Registration Number: NCT02295566

Locations: 🇬🇧
University Southampton NHS Foundation Trust, Southampton, Hampshire, United Kingdom

Use of Inhaled Nitric Oxide to Prevent Pulmonary Hypertension Associated to Stored Blood Transfusion

Phase 2

Withdrawn

Conditions: Hypertension, Pulmonary
Hemolysis

Interventions: Drug: Nitric Oxide

First Posted Date: 2014-08-15

Last Posted Date: 2016-03-18

Lead Sponsor: Massachusetts General Hospital

Registration Number: NCT02217683

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States

Evaluation of the Safety and Tolerability of Inhaled Nitric Oxide to Subjects With Cystic Fibrosis

Phase 1

Completed

Conditions: Cystic Fibrosis

Interventions: Drug: Nitric oxide

First Posted Date: 2013-10-09

Last Posted Date: 2016-06-03

Lead Sponsor: Beyond Air Inc.

Target Recruit Count: 9

Registration Number: NCT01958944

Locations: 🇮🇱
Soroka university, Beer-Sheba, Israel
🇮🇱
Schneider Children's Medical Center of Israel, Petach Tikvah, Israel

Evaluation of the Safety and Tolerability of Nitric Oxide (NO) Via Inhalation to Subjects With Bronchiolitis

Phase 1

Completed

Conditions: Bronchiolitis

Interventions: Drug: Placebo
Drug: Nitric Oxide

First Posted Date: 2013-01-16

Last Posted Date: 2016-05-04

Lead Sponsor: Beyond Air Inc.

Target Recruit Count: 43

Registration Number: NCT01768884

Locations: 🇮🇱
Soroka university, Beer-Sheba, Israel

Inhaled Nitric Oxide and Inhaled Prostacyclin After Cardiac Surgery for Heart Transplant or LVAD Placement

Phase 4

Completed

Conditions: Heart Failure

Interventions: Drug: Nitric Oxide
Drug: Prostacyclin

First Posted Date: 2012-10-30

Last Posted Date: 2017-10-09

Lead Sponsor: Stanford University

Target Recruit Count: 14

Registration Number: NCT01717209

Locations: 🇺🇸
Stanford Hospital and Clinics, Stanford, California, United States

Inhaled Nitric Oxide to Prevent and Treat Bronchopulmonary Dysplasia

Phase 2

Completed

Conditions: Pulmonary Disease

Interventions: Drug: Nitric Oxide
Device: respiratory support

First Posted Date: 2012-01-04

Last Posted Date: 2013-01-28

Lead Sponsor: Fudan University

Target Recruit Count: 400

Registration Number: NCT01503801

Locations: 🇨🇳
Children's Hospital of Fudan University, Shanghai, Shanghai, China

Effects of Nitric Oxide for Inhalation in Myocardial Infarction Size

Phase 2

Completed

Conditions: Acute Myocardial Infarction

Interventions: Drug: MI size at 48-72 hours
Drug: Nitric Oxide

First Posted Date: 2011-07-20

Last Posted Date: 2014-05-21

Lead Sponsor: Universitaire Ziekenhuizen KU Leuven

Target Recruit Count: 250

Registration Number: NCT01398384

Locations: 🇧🇪
Jessa Hospital, Hasselt, Belgium
🇵🇱
John Paul II Hospital, Krakow, Poland
🇭🇺
Semmelweis University Heart Center, Budapest, Hungary

and more 1 locations

Study on the Safety and Efficacy of Nitric Oxide Gel in Subjects With Pressure Sore

Phase 1

Conditions: Pressure Ulcer

Interventions: Drug: Nitric Oxide
Drug: placebo

First Posted Date: 2011-05-11

Last Posted Date: 2012-07-11

Lead Sponsor: China Medical University Hospital

Target Recruit Count: 40

Registration Number: NCT01351493

Locations: 🇨🇳
China Medical University Hospital, Taichung, Taiwan

Nitric Oxide, GeNO Nitrosyl Delivery System

Phase 2

Completed

Conditions: Pulmonary Arterial Hypertension

Interventions: Drug: Nitric Oxide

First Posted Date: 2010-07-19

Last Posted Date: 2024-10-03

Lead Sponsor: Wake Forest University Health Sciences

Target Recruit Count: 10

Registration Number: NCT01165047

Locations: 🇺🇸
Aurora St. Luke's Medical Center, Milwaukee, Wisconsin, United States

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