Pyrazinamide
- Generic Name
- Pyrazinamide
- Brand Names
- Rifater, Tebrazid
- Drug Type
- Small Molecule
- Chemical Formula
- C5H5N3O
- CAS Number
- 98-96-4
- Unique Ingredient Identifier
- 2KNI5N06TI
- Background
A pyrazine that is used therapeutically as an antitubercular agent.
- Indication
For the initial treatment of active tuberculosis in adults and children when combined with other antituberculous agents.
- Associated Conditions
- Active Tuberculosis, Pulmonary Tuberculosis (TB)
- Associated Therapies
- -
The Evaluation of a Standard Treatment Regimen of Anti-tuberculosis Drugs for Patients With MDR-TB
- First Posted Date
- 2015-04-06
- Last Posted Date
- 2023-09-28
- Lead Sponsor
- IUATLD, Inc
- Target Recruit Count
- 588
- Registration Number
- NCT02409290
- Locations
- 🇪🇹
Armauer Hanssen Research Institute, Addis Ababa, Ethiopia
🇪🇹St. Peter's Tuberculosis Specializes Hospital, Addis Ababa, Ethiopia
🇬🇪JSC National Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia
Shortening Treatment by Advancing Novel Drugs
- First Posted Date
- 2015-01-21
- Last Posted Date
- 2019-03-26
- Lead Sponsor
- Global Alliance for TB Drug Development
- Target Recruit Count
- 284
- Registration Number
- NCT02342886
- Locations
- 🇹🇿
Kilimanjaro National Institute for Medical Research, Mwanza, Tanzania
🇿🇦TASK, Bellville, Cape Town, South Africa
🇺🇬Uganda CWRU Research Collaboration, Kampala, Uganda
Assessing PA-824 for Tuberculosis (the APT Trial)
- Conditions
- Interventions
- First Posted Date
- 2014-10-06
- Last Posted Date
- 2023-07-18
- Lead Sponsor
- Johns Hopkins University
- Target Recruit Count
- 157
- Registration Number
- NCT02256696
- Locations
- 🇿🇦
University of Cape Town Lung Institute, Cape Town, South Africa
A Phase 2 to Evaluate the Efficacy, Safety and Tolerability of Combinations of Bedaquiline, Moxifloxacin, PA-824 and Pyrazinamide in Adult Subjects With Drug-Sensitive or Multi Drug-Resistant Pulmonary Tuberculosis.
- Conditions
- Interventions
- First Posted Date
- 2014-07-18
- Last Posted Date
- 2019-07-26
- Lead Sponsor
- Global Alliance for TB Drug Development
- Target Recruit Count
- 240
- Registration Number
- NCT02193776
- Locations
- 🇿🇦
Klerksdorp Tshepong Hospital, Jouberton, Klerksdorp, South Africa
🇿🇦The Aurum Institute: Tembisa Hospital, Tembisa, Gauteng, South Africa
🇹🇿NIMR-Mbeya Medical Research Centre (MMRC), Mbeya, Tanzania
Evaluation of SQ109, High-dose Rifampicin, and Moxifloxacin in Adults With Smear-positive Pulmonary TB in a MAMS Design
- Conditions
- Interventions
- First Posted Date
- 2013-02-07
- Last Posted Date
- 2017-09-20
- Lead Sponsor
- Michael Hoelscher
- Target Recruit Count
- 365
- Registration Number
- NCT01785186
- Locations
- 🇿🇦
The Aurum Institute for Health Research, Johannesburg, South Africa
🇿🇦University of Cape Town, Centre for Tuberculosis Research Innovation, Cape Town, South Africa
🇹🇿NIMR - Mbeya Medical Research Programme, Mbeya, Tanzania
Rifampin-Based Tuberculosis Treatment Versus Rifabutin-Based Tuberculosis Treatment in Persons With HIV
- First Posted Date
- 2012-05-18
- Last Posted Date
- 2018-02-13
- Target Recruit Count
- 71
- Registration Number
- NCT01601626
- Locations
- 🇵🇪
Asociacion Civil Impacta Salud y Educacion - Miraf CRS (11301), Lima, Peru
🇧🇷Instituto de Pesquisa Clinica Evandro Chagas (12101), Rio de Janeiro, Brazil
🇭🇹Les Centres GHESKIO CRS (30022), Port-au-Prince, Haiti
Essentiality of INH in TB Therapy
- Conditions
- Interventions
- First Posted Date
- 2012-05-02
- Last Posted Date
- 2018-04-06
- Target Recruit Count
- 69
- Registration Number
- NCT01589497
- Locations
- 🇿🇦
TASK Applied Science CRS (31718), Bellville, South Africa
🇿🇦University of Cape Town Lung Institute (UCTLI) CRS (31792), Cape Town, Western Cape, South Africa
Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis With(J-M-Pa-Z) (NC-001)
- Conditions
- Interventions
- First Posted Date
- 2010-10-07
- Last Posted Date
- 2017-02-28
- Lead Sponsor
- Global Alliance for TB Drug Development
- Target Recruit Count
- 85
- Registration Number
- NCT01215851
- Locations
- 🇿🇦
Centre for Tuberculosis Research Innovation, UCT Lung Institute, Cape Town, South Africa
🇿🇦Task Applied Science, Karl Bremer Hospital, Cape Town, South Africa
Measurement of Anti-TB Drugs in Lung Tissue From Patients Having Surgery to Treat Tuberculosis
- Conditions
- Interventions
- First Posted Date
- 2009-01-01
- Last Posted Date
- 2019-12-09
- Target Recruit Count
- 19
- Registration Number
- NCT00816426
- Locations
- 🇰🇷
Asan Medical Center, Seoul, Korea, Republic of
🇰🇷Pusan National Unversity Hospital (PNUH), Busan, Korea, Republic of
🇰🇷National Medical Center, Seoul, Korea, Republic of
A Randomized Trial of DOTS Versus Enhanced DOTS for Community Control of Tuberculosis
- Conditions
- First Posted Date
- 2006-04-24
- Last Posted Date
- 2010-08-27
- Target Recruit Count
- 6400
- Registration Number
- NCT00317330
- Locations
- 🇧🇷
Municipal Health Department, Rio de Janeiro, Brazil
Drug Development Updates
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