MedPath

E-7386

Generic Name
E-7386

A Study of E7386 in Combination With Pembrolizumab in Previously Treated Participants With Selected Solid Tumors

Phase 1
Completed
Conditions
Carcinoma, Hepatocellular
Melanoma
Colorectal Neoplasms
Interventions
First Posted Date
2021-10-25
Last Posted Date
2024-10-24
Lead Sponsor
Eisai Inc.
Target Recruit Count
89
Registration Number
NCT05091346
Locations
🇺🇸

Icahn School of Medicine at Mount Sinai, New York, New York, United States

🇺🇸

Emory University, Atlanta, Georgia, United States

🇺🇸

Providence Medical Center, Portland, Oregon, United States

and more 30 locations

A Study to Evaluate the Relative Bioavailability of E7386 Following Oral Administration of Targeted Release (TR) Tablets Compared to an E7386 Immediate Release (IR) Tablet in Healthy Adult Participants

Phase 1
Withdrawn
Conditions
Healthy Volunteers
Interventions
First Posted Date
2021-04-12
Last Posted Date
2023-11-24
Lead Sponsor
Eisai Limited
Registration Number
NCT04840927
Locations
🇬🇧

Quotient Sciences, Nottingham, United Kingdom

A Study of E7386 in Combination With Other Anticancer Drug(s) in Participants With Solid Tumor

Phase 1
Recruiting
Conditions
Neoplasms
Liver Neoplasms
Colorectal Neoplasms
Endometrial Neoplasms
Carcinoma, Hepatocellular
Interventions
First Posted Date
2019-07-05
Last Posted Date
2025-05-13
Lead Sponsor
Eisai Inc.
Target Recruit Count
301
Registration Number
NCT04008797
Locations
🇫🇷

ICANs, Strasbourg, France

🇫🇷

Gustave Roussy Institute (IGR), Villejuif, France

🇮🇹

Clinica Oncologica AOU (Azienda Ospedaliero Universitaria) delle Marche, Ancona, Italy

and more 102 locations

A Food-Effect Study of E7386 in Healthy Participants

Phase 1
Completed
Conditions
Food Effect in Healthy Participants
Interventions
First Posted Date
2019-06-24
Last Posted Date
2019-11-14
Lead Sponsor
Eisai Inc.
Target Recruit Count
17
Registration Number
NCT03996226
Locations
🇺🇸

PPD, Austin, Texas, United States

A Study of E7386 in Participants With Advanced Solid Tumor Including Colorectal Cancer (CRC)

Phase 1
Active, not recruiting
Conditions
Gastrointestinal Tumors
Colorectal Neoplasms
Solid Neoplasms
Interventions
First Posted Date
2019-02-07
Last Posted Date
2025-01-15
Lead Sponsor
Eisai Co., Ltd.
Target Recruit Count
70
Registration Number
NCT03833700
Locations
🇯🇵

Eisai Trial Site#8, Sendai, Miyagi, Japan

🇯🇵

Eisai Trial Site #5, Sapporo, Hokkaido, Japan

🇯🇵

Eisai Trial Site #4, Fukuoka, Japan

and more 5 locations

Study of E7386 in Participants With Selected Advanced Neoplasms

Phase 1
Active, not recruiting
Conditions
Advanced Neoplasms
Interventions
First Posted Date
2017-08-29
Last Posted Date
2024-06-11
Lead Sponsor
Eisai Inc.
Target Recruit Count
60
Registration Number
NCT03264664
Locations
🇬🇧

Royal Marsden Hospital NHS Foundation Trust, Sutton, Surrey, United Kingdom

🇺🇸

Mayo Clinic Comprehensive Caner, Rochester, Minnesota, United States

🇺🇸

USC Norris Comprehensive Cancer Center, Los Angeles, California, United States

and more 6 locations
© Copyright 2025. All Rights Reserved by MedPath