Clozapine

Generic Name
Clozapine
Brand Names
Clozaril, Fazaclo, Versacloz
Drug Type
Small Molecule
Chemical Formula
C18H19ClN4
CAS Number
5786-21-0
Unique Ingredient Identifier
J60AR2IKIC
Background

Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine receptors results in fewer extrapyramida...

Indication

Clozapine is indicated for the treatment of severely ill patients with schizophrenia who fail to respond adequately to standard antipsychotic treatment. Because of the risks of severe neutropenia and of seizure associated with its use, Clozapine should be used only in patients who have failed to respond adequately to standard antipsychotic treatment.
...

Associated Conditions
Suicidal Behaviour, Treatment Resistant Schizophrenia, Advanced dopaminomimetic psychosis
Associated Therapies
-

Study of Clozapine for the Treatment of Psychosis in Patients With Idiopathic Parkinson's Disease

Not Applicable
Completed
Conditions
First Posted Date
2000-02-25
Last Posted Date
2015-03-25
Lead Sponsor
Memorial Hospital of Rhode Island
Target Recruit Count
60
Registration Number
NCT00004826

Comparison of Clozapine vs Olanzapine in Childhood-Onset Psychotic Disorders

First Posted Date
1999-11-04
Last Posted Date
2011-04-12
Lead Sponsor
National Institute of Mental Health (NIMH)
Target Recruit Count
25
Registration Number
NCT00001656
Locations
🇺🇸

National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States

Glycine and D-Cycloserine in Schizophrenia

First Posted Date
1999-11-03
Last Posted Date
2014-06-12
Lead Sponsor
Massachusetts General Hospital
Registration Number
NCT00000372
Locations
🇺🇸

Freedom Trail Clinic, Boston, Massachusetts, United States

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