Alvimopan

Generic Name
Alvimopan
Brand Names
Entereg
Drug Type
Small Molecule
Chemical Formula
C25H32N2O4
CAS Number
156053-89-3
Unique Ingredient Identifier
Q153V49P3Z
Background

Alvimopan is a peripherally acting μ opioid antagonist. It is used to avoid postoperative ileus following small or large bowel resection and accelerates the gastrointestinal recovery period.

Indication

用于手术以及使用阿片类药物导致的胃肠功能紊乱,特发性便秘以及肠易激综合症等。

Associated Conditions
-
Associated Therapies
Gastrointestinal Recovery

Long-Term Safety Evaluation Of Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain

Phase 3
Completed
Conditions
Interventions
First Posted Date
2005-10-19
Last Posted Date
2017-08-30
Lead Sponsor
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Target Recruit Count
805
Registration Number
NCT00241722
Locations
🇬🇧

GSK Investigational Site, Yaxley, Peterborough, United Kingdom

Study of Alvimopan for the Management of Opioid-induced Postoperative Bowel Dysfunction/Postoperative Ileus

Phase 3
Completed
Conditions
First Posted Date
2005-09-21
Last Posted Date
2016-01-11
Lead Sponsor
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Target Recruit Count
660
Registration Number
NCT00205842
Locations
🇺🇸

50 Sites, Exton, Pennsylvania, United States

Study 767905/008 Extension Study: Alvimopan for Treatment of Opioid-Induced Bowel Dysfunction in Cancer Pain Subjects

Phase 2
Completed
Conditions
Interventions
First Posted Date
2005-08-26
Last Posted Date
2015-09-02
Lead Sponsor
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Target Recruit Count
67
Registration Number
NCT00135577
Locations
🇬🇧

GSK Investigational Site, Nottingham, United Kingdom

Study Of Alvimopan Drug For Treatment Of Constipation Due To Prescription Pain Medication

Phase 2
Completed
Conditions
Interventions
First Posted Date
2005-01-19
Last Posted Date
2017-08-30
Lead Sponsor
Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Target Recruit Count
233
Registration Number
NCT00101998
Locations
🇬🇧

GSK Investigational Site, Surrey, United Kingdom

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