Lomitapide

Generic Name
Lomitapide
Brand Names
Juxtapid, Lojuxta
Drug Type
Small Molecule
Chemical Formula
C39H37F6N3O2
CAS Number
182431-12-5
Unique Ingredient Identifier
82KUB0583F
Background

Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R).

Indication

用于纯合子家族性高胆固醇血症以及高胆固醇血症。

Associated Conditions
Homozygous Familial Hypercholesterolaemia (HoFH)
Associated Therapies
-
Clinical Trials
Related News

Efficacy and Safety of Lomitapide in Paediatric Patients With Homozygous Familial Hypercholesterolaemia (HoFH)

First Posted Date
2020-12-23
Last Posted Date
2024-07-08
Lead Sponsor
Amryt Pharma
Target Recruit Count
46
Registration Number
NCT04681170
Locations
🇩🇪

University Hospital of Cologne, Cologne, Germany

🇮🇹

U.O.C. Clinica Medica 1, Padova, Padua, Italy

🇹🇳

E.P.S. Fattouma Bourguiba Hospital, Monastir,, Tunisia

and more 9 locations

Evaluate the Efficacy and Safety of Lomitapide in Pediatric Patients With Homozygous Familial Hypercholesterolemia on Stable Lipid-lowering Therapy

Phase 3
Withdrawn
Conditions
Homozygous Familial Hypercholesterolemia
Interventions
Drug: Lomitapide
First Posted Date
2016-05-09
Last Posted Date
2018-02-22
Lead Sponsor
Aegerion Pharmaceuticals, Inc.
Registration Number
NCT02765841

Global Lomitapide Pregnancy Exposure Registry

Terminated
Conditions
Pregnancy
First Posted Date
2015-03-26
Last Posted Date
2022-12-16
Lead Sponsor
Amryt Pharma
Target Recruit Count
5
Registration Number
NCT02399839
Locations
🇩🇪

Klinikum der Universität München, München, Bavaria, Germany

Effects of Lomitapide on Carotid and Aortic Atherosclerosis

First Posted Date
2015-03-26
Last Posted Date
2017-12-15
Lead Sponsor
Aegerion Pharmaceuticals, Inc.
Registration Number
NCT02399852

Efficacy and Safety of Lomitapide in Japanese Patients With HoFH on Concurrent Lipid-Lowering Therapy

Phase 3
Completed
Conditions
Familial Hypercholesterolemia - Homozygous
Interventions
Drug: lomitapide
First Posted Date
2014-06-24
Last Posted Date
2018-10-10
Lead Sponsor
Aegerion Pharmaceuticals, Inc.
Target Recruit Count
9
Registration Number
NCT02173158

LOWER: Lomitapide Observational Worldwide Evaluation Registry

First Posted Date
2014-05-12
Last Posted Date
2024-03-12
Lead Sponsor
Amryt Pharma
Target Recruit Count
300
Registration Number
NCT02135705
Locations
🇺🇸

NY Heart Center, Syracuse, New York, United States

🇺🇸

Complete Family Care Cholesterol Treatment Center, Sterling Heights, Michigan, United States

🇺🇸

Palmetto Health, Columbia, South Carolina, United States

and more 71 locations

Evaluate the Effect of Ethinyl Estradiol/Norgestimate on the Pharmacokinetics of Lomitapide in Healthy Female Subjects

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: lomitapide
Drug: EE/norgestimate
First Posted Date
2014-03-06
Last Posted Date
2019-03-11
Lead Sponsor
Aegerion Pharmaceuticals, Inc.
Target Recruit Count
32
Registration Number
NCT02080468
Locations
🇺🇸

Covance Clinical Research Unit, Inc, Dallas, Texas, United States

Evaluate the Effect of Atorvastatin on the Pharmacokinetics of Lomitapide in Healthy Subjects.

First Posted Date
2014-03-06
Last Posted Date
2020-03-10
Lead Sponsor
Aegerion Pharmaceuticals, Inc.
Target Recruit Count
32
Registration Number
NCT02080455
Locations
🇺🇸

Covance Clinical Research Unit, Inc, Dallas, Texas, United States

A Comparative Bioavailability Study of Lomitapide 20 mg Intact vs Sprinkled

Phase 1
Completed
Conditions
Healthy
Interventions
Drug: lomitapide
First Posted Date
2014-01-24
Last Posted Date
2018-02-13
Lead Sponsor
Aegerion Pharmaceuticals, Inc.
Target Recruit Count
32
Registration Number
NCT02044419
Locations
🇬🇧

Richmond Pharmacology Ltd, Croydon, Surrey, United Kingdom

Study to Determine the Intra-subject Variability of Pharmacokinetics of Lomitapide in Healthy Subjects

First Posted Date
2013-08-05
Last Posted Date
2020-03-11
Lead Sponsor
Aegerion Pharmaceuticals, Inc.
Target Recruit Count
15
Registration Number
NCT01915771
Locations
🇬🇧

Richmond Pharmacology, Croydon, Surrey, United Kingdom

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