Oxytocin
- Generic Name
- Oxytocin
- Brand Names
- Pitocin
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 50-56-6
- Unique Ingredient Identifier
- 1JQS135EYN
- Background
Sir Henry H. Dale first identified oxytocin and its uterine contractile properties in 1906. Like all other neurohypophysial hormones, oxytocin is composed of nine amino acids with a disulfide bridge between the Cys 1 and 6 residues. In the mid-1950s, synthetic oxytocin was successfully synthesized by a biochemist named Vincent du Vigneaud; he was later recog...
- Indication
Administration of exogenous oxytocin is indicated in the antepartum period to initiate or improve uterine contractions for vaginal delivery in situations where there is fetal or maternal concern. For example, It may be used to induce labor in cases of Rh sensitization, maternal diabetes, preeclampsia at or near term, and when delivery is indicated due to pre...
- Associated Conditions
- Incomplete Abortion, Inevitable abortion, Postpartum Bleeding
- Associated Therapies
- Reinforcement of labor
Effects of Oxytocin Nasal Spray on Social Affiliation
- First Posted Date
- 2008-04-21
- Last Posted Date
- 2019-09-09
- Lead Sponsor
- University of Maryland, Baltimore
- Target Recruit Count
- 27
- Registration Number
- NCT00663039
- Locations
- 🇺🇸
Maryland Psychiatric Research Center, Catonsville, Maryland, United States
Is Oxytocin Given During Surgical Procedure for Abortion Before 12 Weeks of Pregnancy Useful?
- First Posted Date
- 2007-10-08
- Last Posted Date
- 2010-04-16
- Lead Sponsor
- Asker & Baerum Hospital
- Target Recruit Count
- 400
- Registration Number
- NCT00540748
- Locations
- 🇳🇴
Kvinneklinikken SABHF, Baerum, Rud, Norway
Oxytocin Add on Study for Stable Schizophrenic Patients
- First Posted Date
- 2007-07-25
- Last Posted Date
- 2019-09-25
- Lead Sponsor
- David Feifel
- Target Recruit Count
- 21
- Registration Number
- NCT00506909
- Locations
- 🇺🇸
University of California San Diego, San Diego, California, United States
Intranasal Oxytocin in the Treatment of Autism
- First Posted Date
- 2007-06-25
- Last Posted Date
- 2015-10-23
- Lead Sponsor
- Evdokia Anagnostou
- Target Recruit Count
- 19
- Registration Number
- NCT00490802
- Locations
- 🇺🇸
Mount Sinai School of Medicine, New York, New York, United States
Ergot and Oxytocin During Cesarean Delivery Following Failure to Progress in Labour
- Conditions
- First Posted Date
- 2007-06-01
- Last Posted Date
- 2007-06-01
- Target Recruit Count
- 47
- Registration Number
- NCT00481533
- Locations
- 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada
Active Versus Expectant Management of the Third Stage of Labor
- First Posted Date
- 2007-05-15
- Last Posted Date
- 2023-04-12
- Lead Sponsor
- Christiana Care Health Services
- Target Recruit Count
- 218
- Registration Number
- NCT00473707
- Locations
- 🇺🇸
Christiana Care Health System, Newark, Delaware, United States
A Randomized, Control Trial for Preinduction Cervical Ripening
- Conditions
- First Posted Date
- 2006-10-29
- Last Posted Date
- 2008-01-16
- Target Recruit Count
- 540
- Registration Number
- NCT00393731
- Locations
- 🇺🇸
Lyndon B. Johnson Hospital, Houston, Texas, United States
Oxytocin Effects on Cytokines and Endocrine Parameters After LPS Induced Systemic Inflammatory Effects in Healthy Volunteers
- Conditions
- First Posted Date
- 2006-08-03
- Last Posted Date
- 2007-12-11
- Lead Sponsor
- Medical University of Vienna
- Target Recruit Count
- 10
- Registration Number
- NCT00360048
- Locations
- 🇦🇹
Medical University of Vienna, Vienna, Austria
An fMRI Study of the Effect of Intravenous Oxytocin vs. Placebo on Response Inhibition and Face Processing in Autism
- First Posted Date
- 2005-12-09
- Last Posted Date
- 2014-04-30
- Lead Sponsor
- Anagnostou, Evdokia, M.D.
- Target Recruit Count
- 16
- Registration Number
- NCT00263796
- Locations
- 🇺🇸
Mount Sinai School of Medicine, New York, New York, United States
Does the Rapid Intravenous Administration of Oxytocin After Delivery of the Baby Decrease the Bleeding During Cesarean Section in Women at Risk of Bleeding During Cesarean Section?
- Conditions
- Interventions
- First Posted Date
- 2005-11-23
- Last Posted Date
- 2014-03-17
- Lead Sponsor
- University of British Columbia
- Target Recruit Count
- 150
- Registration Number
- NCT00257803
- Locations
- 🇨🇦
BC Women's Hospital, Department of Anesthesia, Vancouver, British Columbia, Canada
Drug Development Updates
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