Oxytocin

Generic Name: Oxytocin

Brand Names: Pitocin

Drug Type: Biotech

Chemical Formula: -

CAS Number: 50-56-6

Unique Ingredient Identifier: 1JQS135EYN

Background: Sir Henry H. Dale first identified oxytocin and its uterine contractile properties in 1906. Like all other neurohypophysial hormones, oxytocin is composed of nine amino acids with a disulfide bridge between the Cys 1 and 6 residues. In the mid-1950s, synthetic oxytocin was successfully synthesized by a biochemist named Vincent du Vigneaud; he was later recog...

Indication: Administration of exogenous oxytocin is indicated in the antepartum period to initiate or improve uterine contractions for vaginal delivery in situations where there is fetal or maternal concern. For example, It may be used to induce labor in cases of Rh sensitization, maternal diabetes, preeclampsia at or near term, and when delivery is indicated due to pre...

Associated Conditions: Incomplete Abortion, Inevitable abortion, Postpartum Bleeding

Associated Therapies: Reinforcement of labor

Clinical Trials

Cervical Traction vs. Active Management of 3rd Stage of Labor

Not Applicable

Conditions: Post Partum Hemorrhage

Interventions: Drug: Oxytocin
Procedure: cervical traction

First Posted Date: 2021-02-10

Last Posted Date: 2021-02-10

Lead Sponsor: Cairo University

Target Recruit Count: 306

Registration Number: NCT04747015

Locations: 🇪🇬
Kasr Alainy medical school, Cairo, Egypt

Prevention of Primary Postpartum Haemorrhage

Phase 2

Conditions: Post Partum Hemorrhage
Primary

Interventions: Drug: Misoprostol
Drug: Oxytocin

First Posted Date: 2021-01-26

Last Posted Date: 2021-02-25

Lead Sponsor: Islamabad Medical and Dental College

Target Recruit Count: 180

Registration Number: NCT04724187

Locations: 🇵🇰
Islamabad medical and Dental College, Islamabad, Federal, Pakistan

Differential Effects of Vasopressin and Oxytocin on Attention Control

Not Applicable

Completed

Conditions: Healthy

Interventions: Drug: Placebo
Drug: Vasopressin
Drug: Oxytocin

First Posted Date: 2021-01-20

Last Posted Date: 2021-01-22

Lead Sponsor: University of Electronic Science and Technology of China

Target Recruit Count: 160

Registration Number: NCT04715737

Locations: 🇨🇳
University of Electronic Science and Technology of China (UESTC), Sichuan, Chengdu, China

Tranexamic Acid for the Prevention of Postpartum Haemorrhage

Phase 1

Conditions: Postpartum Hemorrhage

Interventions: Drug: Tranexamic Acid 100 milligram/Milliliter
Drug: Oxytocin

First Posted Date: 2021-01-13

Last Posted Date: 2021-01-13

Lead Sponsor: Benha University

Target Recruit Count: 60

Registration Number: NCT04707950

Locations: 🇪🇬
Benha university hospital, Banhā, Banha, Egypt
🇪🇬
Benha University, Banhā, Banha, Egypt

Methods to Reduce Blood Loss in Abdominal Myomectomy

Phase 4

Conditions: Abdominal Myomectomy
Blood Loss

Interventions: Drug: Misoprostol 200mcg Tab vaginal
Procedure: pericervical hemostatic tourniquet
Drug: Carbetocin
Drug: Oxytocin

First Posted Date: 2020-10-22

Last Posted Date: 2020-10-22

Lead Sponsor: Cairo University

Target Recruit Count: 120

Registration Number: NCT04595812

Determination of Blood Loss After CS

Early Phase 1

Conditions: Effect of Drug

Interventions: Drug: Tranexamic acid
Drug: Oxytocin

First Posted Date: 2020-09-16

Last Posted Date: 2020-09-16

Lead Sponsor: Ain Shams University

Target Recruit Count: 130

Registration Number: NCT04549012

Bilateral Uterine Artery Ligation During the Cesarean Delivery of Twins

Not Applicable

Conditions: Cesarean Section Complications

Interventions: Procedure: bilateral uterine artery ligation
Drug: Oxytocin

First Posted Date: 2020-08-19

Last Posted Date: 2020-09-21

Lead Sponsor: Aswan University Hospital

Target Recruit Count: 400

Registration Number: NCT04518176

Locations: 🇪🇬
Aswan University Hospital, Aswan, Egypt

Oxytocin and Approach-avoid in Grief

Not Applicable

Completed

Conditions: Prolonged Grief Disorder
Bereavement

Interventions: Drug: Syntocinon
Drug: Placebo

First Posted Date: 2020-08-10

Last Posted Date: 2021-04-29

Lead Sponsor: University of Arizona

Target Recruit Count: 44

Registration Number: NCT04505904

Locations: 🇺🇸
University of Arizona, Tucson, Arizona, United States

A Pilot Feasibility Study of IM OXT on Fear of Pain and Trust in Physical Therapist During OP Rehabilitation After TKA

Phase 2

Withdrawn

Conditions: Osteoarthritis, Knee

Interventions: Drug: Placebo
Drug: Oxytocin

First Posted Date: 2020-07-30

Last Posted Date: 2021-06-02

Lead Sponsor: Wake Forest University Health Sciences

Registration Number: NCT04493229

Locations: 🇺🇸
Wake Forest Baptist Health, Winston-Salem, North Carolina, United States

Misoprostol With Mechanical Dilation Versus Oxytocin With Mechanical Dilation for High-risk Pregnancy Inductions

Not Applicable

Completed

Conditions: Cesarean Section
Oxytocin
Misoprostol
High Risk Pregnancy

Interventions: Drug: Oxytocin
Drug: Misoprostol

First Posted Date: 2020-07-30

Last Posted Date: 2022-06-14

Lead Sponsor: Thomas Jefferson University

Target Recruit Count: 150

Registration Number: NCT04492072

Locations: 🇺🇸
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

© Copyright 2024. All Rights Reserved by MedPath

Home Terms & Conditions Privacy Policy