Donepezil

Generic Name: Donepezil

Brand Names: Adlarity, Aricept, Namzaric

Drug Type: Small Molecule

Chemical Formula: C_₂₄H_₂₉NO_₃

CAS Number: 120014-06-4

Unique Ingredient Identifier: 8SSC91326P

Background: In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and in some cases, is used to manage other ty...

Indication: Donepezil, administered orally or via transdermal delivery system, is indicated for the treatment of dementia of the Alzheimer's type. It is also available as an extended-release capsule in combination with memantine for the treatment of moderate-to-severe dementia of the Alzheimer's type in patients previously stabilized on 10mg of donepezil hydrochloride o...

Associated Conditions: Alzheimer's Disease (AD), Dementia With Lewy Body Disease, Dementia due to Parkinson's disease, Dementia of the Alzheimer's Type, Vascular Dementia (VaD), Moderate Alzheimer's Type Dementia, Severe Alzheimer's Type Dementia

Associated Therapies: -

Clinical Trials

Efficacy and Safety of Aricept in the Treatment of Severe Alzheimer's Disease

Phase 3

Completed

Conditions: Dementia
Alzheimer's Disease

First Posted Date: 2004-11-10

Last Posted Date: 2011-04-01

Lead Sponsor: Eisai Inc.

Target Recruit Count: 229

Registration Number: NCT00096473

Locations: 🇫🇷
Hôpital Broca-La Rochefoucauld, Paris, France

Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor

Phase 2

Completed

Conditions: Radiation Toxicity
Brain and Central Nervous System Tumors

First Posted Date: 2003-10-07

Last Posted Date: 2021-09-09

Lead Sponsor: Wake Forest University Health Sciences

Target Recruit Count: 68

Registration Number: NCT00070161

Locations: 🇺🇸
Comprehensive Cancer Center at Wake Forest University, Winston-Salem, North Carolina, United States
🇺🇸
Regional Radiation Oncology Center at Rome, Rome, Georgia, United States
🇺🇸
CCOP - Upstate Carolina, Spartanburg, South Carolina, United States

and more 1 locations

Independent Studies of Dextromethorphan and of Donepezil Hydrochloride for Rett Syndrome

Phase 3

Conditions: Rett Syndrome

First Posted Date: 2003-09-30

Last Posted Date: 2005-06-24

Lead Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Target Recruit Count: 90

Registration Number: NCT00069550

Locations: 🇺🇸
Kennedy Krieger Institute, Baltimore, Maryland, United States

Improving Memory in Patients With Multiple Sclerosis

Phase 3

Withdrawn

Conditions: Multiple Sclerosis

First Posted Date: 2003-06-19

Last Posted Date: 2017-04-25

Lead Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Registration Number: NCT00062972

Locations: 🇺🇸
University Hospital and Medical Center, Stony Brook, New York, United States

Donepezil and Vitamin E to Prevent Side Effects Caused By Radiation Therapy to the Head in Patients Receiving Treatment for Small Cell Lung Cancer

Phase 3

Completed

Conditions: Cognitive/Functional Effects
Delirium
Depression
Lung Cancer
Radiation Toxicity

Interventions: Dietary Supplement: vitamin E
Other: placebo
Drug: donepezil hydrochloride

First Posted Date: 2003-05-29

Last Posted Date: 2016-07-13

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 9

Registration Number: NCT00006349

Locations: 🇺🇸
Medcenter One Health System, Bismarck, North Dakota, United States
🇺🇸
CCOP - Iowa Oncology Research Association, Des Moines, Iowa, United States
🇺🇸
Mayo Clinic Cancer Center, Rochester, Minnesota, United States

and more 12 locations

Memory and Mental Health in Aging

Not Applicable

Completed

Conditions: Memory Disorders

First Posted Date: 2002-08-13

Last Posted Date: 2013-12-05

Lead Sponsor: Stanford University

Target Recruit Count: 200

Registration Number: NCT00043589

Locations: 🇺🇸
Aging Clinical Research Center, VA Palo Alto Health Care System, Palo Alto, California, United States

Treatment for Early Memory Loss

Phase 4

Completed

Conditions: Cognition Disorders
Alzheimer Disease

First Posted Date: 2002-07-26

Last Posted Date: 2014-03-03

Lead Sponsor: University of Iowa

Target Recruit Count: 40

Registration Number: NCT00042172

Locations: 🇺🇸
University of Iowa Department of Psychiatry, Iowa City, Iowa, United States

Prevention of Cognitive Decline in Alzheimer's Disease by Ingested Interferon Alpha

Phase 2

Conditions: Memory Disorders
Alzheimer's Disease

First Posted Date: 2002-02-22

Last Posted Date: 2008-02-05

Lead Sponsor: National Center for Research Resources (NCRR)

Registration Number: NCT00031018

Locations: 🇺🇸
University of Texas - Houston, Gerontology Center of the UTMSI, Houston, Texas, United States

Donepezil to Treat Dementia in Parkinson's Disease

Phase 4

Completed

Conditions: Parkinson Disease

First Posted Date: 2002-02-18

Last Posted Date: 2008-03-04

Lead Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)

Target Recruit Count: 28

Registration Number: NCT00030979

Locations: 🇺🇸
National Institute of Neurological Disorders and Stroke (NINDS), Bethesda, Maryland, United States

Electrophysiologic Measures of Treatment Response in Alzheimer Disease

Phase 4

Completed

Conditions: Alzheimer Disease

First Posted Date: 2001-07-05

Last Posted Date: 2009-01-21

Lead Sponsor: US Department of Veterans Affairs

Registration Number: NCT00018278

Locations: 🇺🇸
Department of Veterans Affairs, San Diego, California, United States

Drug Development Updates

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