Methotrexate

Generic Name: Methotrexate

Brand Names: Metoject, Nordimet, Otrexup, Rasuvo, Reditrex, Trexall, Xatmep, Jylamvo

Drug Type: Small Molecule

Chemical Formula: C_₂₀H_₂₂N_₈O_₅

CAS Number: 59-05-2

Unique Ingredient Identifier: YL5FZ2Y5U1

Background: Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division in neoplastic diseases such as breast ca...

Indication: Methotrexate oral solution is indicated for pediatric acute lymphoblastic leukemia and pediatric polyarticular juvenile idiopathic arthritis. Methotrexate injections for subcutaneous use are indicated for severe active rheumatoid arthritis, polyarticular juvenile idiopathic arthritis and severe, recalcitrant, disabling psoriasis.
...

Associated Conditions: Acute Lymphoblastic Leukemia (ALL), Acute Promyelocytic Leukemia, Bladder Cancer, Breast Cancer, Central Nervous System Lymphoma, Crohn's Disease (CD), Dermatomyositis (DM), Extrauterine Pregnancy, Gestational Trophoblastic Neoplasia, Graft-versus-host Disease (GVHD), Meningeal leukemia, Multiple Sclerosis, Mycosis Fungoides (MF), Non-Hodgkin's Lymphoma (NHL), Non-Hodgkin's Lymphoma, Relapsed, Osteosarcoma, Polyarticular Juvenile Idiopathic Arthritis, Polymyositis, Rheumatoid Arthritis, Soft Tissue Sarcoma, Squamous Cell Carcinoma of the Head and Neck (SCCHN), Systemic Lupus Erythematosus, Uveitis, Nonleukemic meningeal cancer, Refractory Non-Hodgkin's lymphoma, Refractory Takayasu arteritis, Severe Psoriasis

Associated Therapies: Medically induced abortion

Clinical Trials

Combination Chemotherapy in Treating Patients With Neurofibromatosis and Progressive Plexiform Neurofibromas

Phase 2

Completed

Conditions: Neurofibromatosis Type 1
Precancerous Condition

Interventions: Drug: Methotrexate
Drug: Vinblastine

First Posted Date: 2003-01-27

Last Posted Date: 2018-08-08

Lead Sponsor: Children's Hospital of Philadelphia

Target Recruit Count: 23

Registration Number: NCT00030264

Locations: 🇺🇸
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States

Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic Leukemia

First Posted Date: 2003-01-27

Last Posted Date: 2014-02-27

Lead Sponsor: National Cancer Institute (NCI)

Target Recruit Count: 220

Registration Number: NCT00022737

Locations: 🇺🇸
Children's Oncology Group, Arcadia, California, United States

Methotrexate and Thiotepa in Treating Patients With Newly Diagnosed Primary CNS Lymphoma

Phase 2

Completed

Conditions: Lymphoma

First Posted Date: 2003-01-27

Last Posted Date: 2013-06-24

Lead Sponsor: New Approaches to Brain Tumor Therapy Consortium

Registration Number: NCT00045539

Locations: 🇺🇸
Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States
🇺🇸
Comprehensive Cancer Center at Wake Forest University, Winston-Salem, North Carolina, United States
🇺🇸
Comprehensive Cancer Center at University of Alabama at Birmingham, Birmingham, Alabama, United States

and more 6 locations

Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia

Phase 3

Completed

Conditions: Leukemia

Interventions: Drug: cyclophosphamide
Drug: leucovorin calcium
Drug: cytarabine
Drug: daunorubicin hydrochloride
Drug: mercaptopurine
Drug: dexamethasone
Drug: methotrexate
Drug: vincristine sulfate
Drug: pegaspargase
Drug: thioguanine

First Posted Date: 2003-01-27

Last Posted Date: 2023-04-06

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 1076

Registration Number: NCT00005596

Locations: 🇺🇸
Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore, Maryland, United States
🇺🇸
Floating Hospital for Children, Boston, Massachusetts, United States
🇺🇸
Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States

and more 119 locations

Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia

Phase 3

Completed

Conditions: Leukemia

Interventions: Drug: dexamethasone
Drug: cyclophosphamide
Drug: leucovorin calcium
Drug: cytarabine
Drug: daunorubicin hydrochloride
Drug: mercaptopurine
Drug: methotrexate
Drug: vincristine sulfate
Drug: pegaspargase
Drug: thioguanine

First Posted Date: 2003-01-27

Last Posted Date: 2023-04-06

Lead Sponsor: Children's Oncology Group

Target Recruit Count: 838

Registration Number: NCT00005585

Locations: 🇨🇦
Hospital for Sick Children, Toronto, Ontario, Canada
🇺🇸
Children's Memorial Hospital - Chicago, Chicago, Illinois, United States
🇺🇸
Floating Hospital for Children, Boston, Massachusetts, United States

and more 119 locations

Comparison of Different Combination Chemotherapy Regimens in Treating Infants With Acute Lymphoblastic Leukemia

Phase 3

Completed

Conditions: Leukemia

Interventions: Drug: asparaginase
Drug: cytarabine
Drug: mercaptopurine
Drug: methotrexate
Drug: prednisolone
Drug: vincristine sulfate

First Posted Date: 2003-01-27

Last Posted Date: 2014-02-17

Lead Sponsor: Dutch Childhood Oncology Group

Target Recruit Count: 350

Registration Number: NCT00015873

Locations: 🇮🇹
Ospedale San Gerardo, Monza, Italy
🇳🇱
Erasmus MC - Sophia Children's Hospital, Rotterdam, Netherlands
🇬🇧
Royal Liverpool Children's Hospital, Alder Hey, Liverpool, England, United Kingdom

and more 29 locations

Chemotherapy and Radiation Therapy in Treating Patients With HIV-Related Primary Central Nervous System Lymphoma

Phase 2

Conditions: Lymphoma

First Posted Date: 2003-01-27

Last Posted Date: 2013-09-20

Lead Sponsor: Centro di Riferimento Oncologico - Aviano

Target Recruit Count: 14

Registration Number: NCT00003261

Locations: 🇮🇹
Centro di Riferimento Oncologico - Aviano, Aviano, Italy

Chemotherapy Plus Surgery in Treating Women With Breast Cancer

Phase 3

Completed

Conditions: Breast Cancer

First Posted Date: 2003-01-27

Last Posted Date: 2013-09-17

Lead Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Target Recruit Count: 450

Registration Number: NCT00003013

Locations: 🇦🇹
Kaiser Franz Josef Hospital, Vienna, Austria
🇨🇿
Radiotherapy Institute, Ostrava-Poruba, Czech Republic
🇸🇰
St. Elizabeth Cancer Institute Hospital, Bratislava, Slovakia

and more 25 locations

Chemotherapy and Peripheral Stem Cell Transplant With or Without Monoclonal Antibody Therapy in Treating Patients With Non-Hodgkin's Lymphoma

Phase 3

Completed

Conditions: Lymphoma

First Posted Date: 2003-01-27

Last Posted Date: 2013-08-12

Lead Sponsor: Commissie Voor Klinisch Toegepast Onderzoek

Target Recruit Count: 340

Registration Number: NCT00012051

Locations: 🇳🇱
Academisch Medisch Centrum at University of Amsterdam, Amsterdam, Netherlands
🇧🇪
U.Z. Gasthuisberg, Leuven, Belgium
🇳🇱
HagaZiekenhuis - Locatie Leyenburg, 's-Gravenhage, Netherlands

and more 14 locations

Combination Chemotherapy in Treating Women With Stage III Breast Cancer

Phase 3

Suspended

Conditions: Breast Cancer

First Posted Date: 2003-01-27

Last Posted Date: 2013-08-02

Lead Sponsor: Grupo Oncologico Cooperativo del Sur

Registration Number: NCT00002696

Locations: 🇦🇷
Unidad Oncologica Del Comahue, Neuquen, Argentina
🇦🇷
Centro De Oncologia y Terapia Radiante, Santa Rosa, La Pampa, Argentina
🇦🇷
Policlinica Privada Instituto De Medicina Nuclear, Bahia Blanca, Buenos Aires, Argentina

and more 3 locations

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

Home Terms & Conditions Privacy Policy