托特罗定 (Detrol, Detrusitol)

概览

Tolterodine is a muscarinic receptor antagonist used to treat overactive bladder with urinary incontinence, urgency, and frequency.

作用机制

Both tolterodine and its active metabolite, 5-hydroxymethyltolterodine, act as competitive antagonists at muscarinic receptors. This antagonism results in inhibition of bladder contraction, decrease in detrusor pressure, and an incomplete emptying of the bladder.

适应症

For the treatment of overactive bladder (with symptoms of urinary frequency, urgency, or urge incontinence).

• Urinary Urge Incontinence