Sodium lauryl sulfate

Generic Name: Sodium lauryl sulfate

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₁₂H_₂₅NaO_₄S

CAS Number: 151-21-3

Unique Ingredient Identifier: 368GB5141J

Background: Sodium Lauryl Sulfate (SLS) is an anionic surfactant naturally derived from coconut and/or palm kernel oil. It usually consists of a mixture of sodium alkyl sulfates, mainly the lauryl. SLS lowers surface tension of aqueous solutions and is used as fat emulsifier, wetting agent, and detergent in cosmetics, pharmaceuticals and toothpastes. It is also used in creams and pastes to properly disperse the ingredients and as research tool in protein biochemistry. SLS also has some microbicidal activity.

Indication: SLS is used as a surfactant in shampoos and toothpastes. SLS also has microbicidal activities against both enveloped (Herpes simplex viruses, HIV-1, Semliki Forest virus) and nonenveloped (papillomaviruses, reovirus, rotavirus and poliovirus) viruses, although it has not been approved for this use.

Associated Conditions: -

Associated Therapies: -

Clinical Trials

Heterologous expression, purification, and biochemical characterization of protease 3075

Protease 3075, a novel enzyme from thermophilic Cohnella sp. A01, was characterized through recombinant production in E. coli BL21. It exhibits optimal activity at 70°C and pH 6, with enhanced stability in the presence of Tween 80 and acetone. Docking and molecular dynamics simulations revealed hydrogen bonds and Van der Waals forces stabilize the enzyme-Tween 80 interaction, increasing structural stability. The enzyme shows potential for industrial applications, particularly in detergents.

nature.com

2 months ago

Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in ...

Detailed experimental protocols for Droplet Hi-C and Paired Hi-C, including fixation, in situ Hi-C, and single-cell sequencing library construction, are described. Data processing and analysis methods for Droplet Hi-C data, such as demultiplexing, mapping, and extracting single-cell contacts, are outlined. The article also covers the analysis of chromatin interactions, compartments, domains, loops, and multi-way interactions, as well as the identification of structural variations (SVs) and extrachromosomal DNA (ecDNA) candidates. Ethical approval for specimen collection is noted.

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