DeepMed Research

Lactic acid

Generic Name: Lactic acid

Brand Names: Dextrose and Electrolyte No. 75, Dianeal, Dianeal Low Calcium 1.5, Dianeal Pd-2/1.5, Extraneal, Glycerolyte 57, Ionosol-MB, Lactate 1-2-3, Lactated Ringers, Nxstage Pureflow, Physioneal 40, Plasma-lyte R, Prismasol, Ringers

Drug Type: Small Molecule

Chemical Formula: C_₃H_₆O_₃

CAS Number: 50-21-5

Unique Ingredient Identifier: 3B8D35Y7S4

Background: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed) Sodium lactate is the sodium salt of lactic acid, and has a mild saline taste. It is produced by fermentation of a sugar source, such as corn or beets, and then, by neutralizing the resulting lactic acid to create a compound having the formula NaC3H5O3.

Lactic acid was one of active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020.

Indication: For use as an alkalinizing agent.

Associated Conditions: Corns, Dehydration, Fluid Loss, Hyperkeratosis, Lichenification, Shock, Hypovolemic, Vasoplegic Shock, Verruca (Warts), Mild Metabolic acidosis, Mild, moderate Metabolic Acidosis, Moderate Metabolic acidosis

Associated Therapies: Chemical contraception, Electrolyte replacement, Fluid replacement therapy, Parenteral Nutrition, Peritoneal dialysis therapy, Urine alkalinization therapy

Clinical Trials

ELI in TBI 24 Hour

Phase 2

Not yet recruiting

Conditions: Traumatic Brain Injury

Interventions: Drug: Sodium Lactate
Drug: placebo

First Posted Date: 2024-11-22

Last Posted Date: 2024-11-22

Lead Sponsor: University of California, Los Angeles

Target Recruit Count: 264

Registration Number: NCT06701760

Study SOLACE SEPSIS

Phase 2

Recruiting

Conditions: Septic Shock
Intracranial Hypertension

Interventions: Drug: 3% NaCl
Drug: Sodium Lactate

First Posted Date: 2024-10-09

Last Posted Date: 2025-04-13

Lead Sponsor: University Hospital Pilsen

Target Recruit Count: 40

Registration Number: NCT06634069

Locations: 🇨🇿
University Hospital Pilsen, Pilsen, Czech republic, Czechia

Combined Microneedling With Either 1% Lactic Acid Solution or Vitamin D3 or Triamcinolone Acetonide in The Treatment of Alopecia Areata

Not Applicable

Recruiting

Conditions: Alopecia Areata

Interventions: Drug: Lactic Acid
Drug: Saline
Drug: vit D
Drug: Triamcinolone Acetonide

First Posted Date: 2024-03-25

Last Posted Date: 2024-03-25

Lead Sponsor: Zagazig University

Target Recruit Count: 44

Registration Number: NCT06327581

Locations: 🇪🇬
Rana Ehab, Zagazig, Egypt

Feasibility of Conducting a Clinical Trial Assessing Efficacy of Lactate as Adjunctive Therapy in Patients With Major Depressive Disorder

Phase 2

Not yet recruiting

Conditions: Major Depressive Disorder

Interventions: Drug: Placebo
Drug: Sodium lactate

First Posted Date: 2023-12-13

Last Posted Date: 2023-12-13

Lead Sponsor: Centre Hospitalier Universitaire Vaudois

Target Recruit Count: 46

Registration Number: NCT06168175

STA363 in the Treatment of Lumbar Disc Herniation

Phase 1

Recruiting

Conditions: Lumbar Disc Herniation

Interventions: Drug: Placebo
Drug: Lactic Acid

First Posted Date: 2023-09-01

Last Posted Date: 2023-09-01

Lead Sponsor: Stayble Therapeutics

Target Recruit Count: 24

Registration Number: NCT06022263

Locations: 🇵🇱
Samodzielny Publiczny Szpital Kliniczny nr 4, Klinika Ortopedii i Rehabilitacji, Lublin, Lubelskie, Poland

Hypertonic Lactate After Cardiac Arrest

Phase 2

Recruiting

Conditions: Cardiac Arrest
Ischemia Reperfusion Injury
Anoxic Brain Injury

Interventions: Drug: Sodium Lactate Solution

First Posted Date: 2021-08-13

Last Posted Date: 2025-02-21

Lead Sponsor: Erasme University Hospital

Target Recruit Count: 125

Registration Number: NCT05004610

Locations: 🇧🇪
Erasme Hospital, Brussels University Hospital (HUB), Brussels, Belgium

Sodium Lactate and Brain Relaxation (LSD)

Phase 3

Completed

Conditions: Sodium Lactate
Intracranial Hypertension
Brain Relaxation

Interventions: Drug: Mannitol 20% Infusion
Drug: Sodium Lactate

First Posted Date: 2020-07-28

Last Posted Date: 2023-09-13

Lead Sponsor: Centre Hospitalier Universitaire de Besancon

Target Recruit Count: 50

Registration Number: NCT04488874

Locations: 🇫🇷
CHU de Besançon, Besancon, France

The Effect Lactate Administration on Cerebral Blood Flow During Hypoglycemia

Not Applicable

Conditions: Type1diabetes
Hypoglycemia Unawareness

Interventions: Drug: Sodium Lactate
Drug: Sodium chloride

First Posted Date: 2018-11-05

Last Posted Date: 2018-11-05

Lead Sponsor: Radboud University Medical Center

Target Recruit Count: 10

Registration Number: NCT03730909

Locations: 🇳🇱
Radoud university medical center, Nijmegen, Netherlands

The Effect of Intravenous Lactate on Brain Lactate Concentrations During Hypoglycemia

Not Applicable

Completed

Conditions: Type 1 Diabetes Mellitus With Hypoglycemia

Interventions: Drug: SodiumChloride
Drug: Sodium Lactate

First Posted Date: 2017-09-19

Last Posted Date: 2017-09-19

Lead Sponsor: Radboud University Medical Center

Target Recruit Count: 19

Registration Number: NCT03286816

Locations: 🇳🇱
Radboud umc, Nijmegen, Netherlands

A Single Ascending Dose Study of Safety and Tolerability of STA363 Compared to Placebo in 15 Patients With Chronic Discogenic Low Back Pain

Phase 1

Completed

Conditions: Low Back Pain

Interventions: Drug: Placebo
Drug: STA363

First Posted Date: 2017-02-16

Last Posted Date: 2020-02-18

Lead Sponsor: Stayble Therapeutics

Target Recruit Count: 15

Registration Number: NCT03055845

Locations: 🇸🇪
Stockholm Spine Center, Löwenströmska Sjukhuset, Upplands Väsby, Sweden

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