Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Cyclophosphamide is indicated for the treatment of malignant lymphomas, multiple myeloma, leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma, and carcinoma of the breast. It is also indicated for the treatment of biopsy-proven minimal change nephrotic syndrome in pediatric patients.
Tulane University School of Medicine, New Orleans, Louisiana, United States
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids, Michigan, United States
NYU Langone Hospital - Long Island, Mineola, New York, United States
Eastern Maine Medical Center, Bangor, Maine, United States
University of Texas Southwestern Medical Center, Dallas, Texas, United States
Advocate Children's Hospital-Oak Lawn, Oak Lawn, Illinois, United States
Birmingham Children's Hospital, Birmingham, England, United Kingdom
Watford General Hospital, Herts, England, United Kingdom
Leeds Cancer Centre at St. James's University Hospital, Leeds, England, United Kingdom
Sinai Hospital of Baltimore, Baltimore, Maryland, United States
Northwest Hospital Center, Randallstown, Maryland, United States
Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium, Seattle, Washington, United States
Azienda Ospedaliera G. Rummo, Benevento, BN, Italy
Policlinico Monteluce, Sant'Andrea delle Frate, PG, Italy
Universitร Federico II, Cattedra di Oncologia Medica, Napoli, Italy
National Cancer Institute (NCI), Bethesda, Maryland, United States
Tower Cancer Research Foundation, Beverly Hills, California, United States
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill, North Carolina, United States
Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
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