Overview
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Background
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Indication
Cyclophosphamide is indicated for the treatment of malignant lymphomas, multiple myeloma, leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma, and carcinoma of the breast. It is also indicated for the treatment of biopsy-proven minimal change nephrotic syndrome in pediatric patients.
Associated Conditions
- Acute Lymphoblastic Leukaemias (ALL)
- Acute Myeloid Leukemia
- Acute monocytic leukemia
- Adenocarcinoma of the Ovaries
- Breast Cancer
- Burkitt Lymphoma
- Chronic Lymphocytic Leukemia
- Chronic Myelogenous Leukemia (CML)
- Hodgkins Disease (HD)
- Lung Cancer
- Lupus
- Lymphocytic Lymphomas
- Lymphoma
- Multiple Myeloma (MM)
- Multiple Sclerosis
- Nephrotic syndrome with lesion of minimal change glomerulonephritis
- Non-Hodgkin's Lymphoma (NHL)
- Retinoblastoma
- Advanced Alibert-Bazin syndrome
- Chronic Granulocytic Leukemias
- Disseminated Neuroblastoma (NB)
- Histiocytic lymphoma
- Mixed-cell type lymphoma
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2008/03/05 | Phase 2 | Completed | Children's Medical Center Dallas | ||
2008/02/29 | Phase 3 | Terminated | |||
2008/02/29 | Phase 3 | Terminated | |||
2008/02/28 | Phase 1 | Terminated | |||
2008/02/22 | Phase 1 | Completed | |||
2008/02/20 | Not Applicable | Completed | |||
2008/02/15 | Phase 1 | Terminated | |||
2008/02/14 | Phase 3 | Completed | Sun Yat-sen University | ||
2008/02/14 | Phase 3 | Completed | Hellenic Oncology Research Group | ||
2008/02/13 | Phase 3 | Completed | Associazione Italiana Ematologia Oncologia Pediatrica |
FDA Drug Approvals
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Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
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Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
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Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
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Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
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|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
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|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||