Cyclophosphamide
- Generic Name
- Cyclophosphamide
- Brand Names
- Procytox
- Drug Type
- Small Molecule
- Chemical Formula
- C7H15Cl2N2O2P
- CAS Number
- 50-18-0
- Unique Ingredient Identifier
- 6UXW23996M
- Background
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
- Indication
Cyclophosphamide is indicated for the treatment of malignant lymphomas, multiple myeloma, leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma, and carcinoma of the breast. It is also indicated for the treatment of biopsy-proven minimal change nephrotic syndrome in pediatric patients.
- Associated Conditions
- Acute Lymphoblastic Leukaemias (ALL), Acute Myeloid Leukemia, Acute monocytic leukemia, Adenocarcinoma of the Ovaries, Breast Cancer, Burkitt Lymphoma, Chronic Lymphocytic Leukemia, Chronic Myelogenous Leukemia (CML), Hodgkins Disease (HD), Lung Cancer, Lupus, Lymphocytic Lymphomas, Lymphoma, Multiple Myeloma (MM), Multiple Sclerosis, Nephrotic syndrome with lesion of minimal change glomerulonephritis, Non-Hodgkin's Lymphoma (NHL), Retinoblastoma, Advanced Alibert-Bazin syndrome, Chronic Granulocytic Leukemias, Disseminated Neuroblastoma (NB), Histiocytic lymphoma, Mixed-cell type lymphoma
- Associated Therapies
- -
Combination Chemotherapy in Treating Patients Who Have Extensive-Stage Small Cell Lung Cancer
- Conditions
- Lung Cancer
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-09-17
- Lead Sponsor
- Commissie Voor Klinisch Toegepast Onderzoek
- Target Recruit Count
- 250
- Registration Number
- NCT00003696
- Locations
- ๐ณ๐ฑ
Vrije Universiteit Medisch Centrum, Amsterdam, Netherlands
Combination Chemotherapy With or Without Thalidomide in Treating Patients With Multiple Myeloma
- Conditions
- Multiple Myeloma and Plasma Cell Neoplasm
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-09-17
- Lead Sponsor
- Commissie Voor Klinisch Toegepast Onderzoek
- Target Recruit Count
- 450
- Registration Number
- NCT00028886
- Locations
- ๐ง๐ช
U.Z. Gasthuisberg, Leuven, Belgium
๐ณ๐ฑIsala Klinieken - locatie Sophia, Zwolle, Netherlands
๐ณ๐ฑAcademisch Medisch Centrum at University of Amsterdam, Amsterdam, Netherlands
Combination Chemotherapy Plus Filgrastim With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma
- Conditions
- Lymphoma
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-09-17
- Lead Sponsor
- Commissie Voor Klinisch Toegepast Onderzoek
- Target Recruit Count
- 400
- Registration Number
- NCT00028717
- Locations
- ๐ณ๐ฑ
Academisch Medisch Centrum at University of Amsterdam, Amsterdam, Netherlands
๐ณ๐ฑMedisch Spectrum Twente, Enschede, Netherlands
๐ณ๐ฑDaniel Den Hoed Cancer Center at Erasmus Medical Center, Rotterdam, Netherlands
Combination Chemotherapy Followed by Surgery and Peripheral Stem Cell or Bone Marrow Transplantation in Treating Infants With Newly Diagnosed Neuroblastoma
- Conditions
- Neuroblastoma
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-09-17
- Lead Sponsor
- European Infant Neuroblastoma Study Group - 1999
- Registration Number
- NCT00025649
- Locations
- ๐ธ๐ช
Ostra Sjukhuset, Gothenburg, Sweden
๐ซ๐ทCentre Hospitalier Regional de Purpan, Toulouse, France
๐ณ๐ดRikshospitalet University Hospital, Oslo, Norway
Combination Chemotherapy in Treating Infants With Newly Diagnosed Neuroblastoma
- Conditions
- Neuroblastoma
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-09-17
- Lead Sponsor
- European Infant Neuroblastoma Study Group - 1999
- Registration Number
- NCT00025610
- Locations
- ๐จ๐ญ
Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
๐ฆ๐นSt. Anna Children's Hospital, Vienna, Austria
๐ง๐ชUniversitair Ziekenhuis Gent, Ghent, Belgium
Chemotherapy Plus Surgery in Treating Women With Breast Cancer
- Conditions
- Breast Cancer
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-09-17
- Lead Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
- Target Recruit Count
- 450
- Registration Number
- NCT00003013
- Locations
- ๐ฆ๐น
Kaiser Franz Josef Hospital, Vienna, Austria
๐จ๐ฟRadiotherapy Institute, Ostrava-Poruba, Czech Republic
๐ธ๐ฐSt. Elizabeth Cancer Institute Hospital, Bratislava, Slovakia
Combination Chemotherapy Followed by Surgery in Treating Infants With Newly Diagnosed Neuroblastoma
- Conditions
- Neuroblastoma
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-09-17
- Lead Sponsor
- European Infant Neuroblastoma Study Group - 1999
- Registration Number
- NCT00025623
- Locations
- ๐ณ๐ด
Rikshospitalet University Hospital, Oslo, Norway
๐จ๐ญCentre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
๐ซ๐ทCentre Hospitalier Regional de Purpan, Toulouse, France
High-Dose Chemotherapy Compared With Standard Chemotherapy in Treating Patients With Stage III or Stage IV Ovarian Epithelial Cancer That Has Been Removed During Surgery
- Conditions
- Ovarian Cancer
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-09-17
- Lead Sponsor
- EBMT Solid Tumors Working Party
- Registration Number
- NCT00004921
- Locations
- ๐ฉ๐ช
Klinikum Nuernberg - Klinikum Nord, Nuernberg, Germany
๐ฎ๐นOspedale San Bortolo, Vicenza, Italy
๐ฆ๐นSozialmedizinisches Zentrum Ost - Donauspital, Vienna, Austria
Chemotherapy Followed by Radiation Therapy and Peripheral Stem Cell Transplant Compared With Chemotherapy Plus Interferon Alfa in Treating Patients With Stage III or Stage IV Mantle Cell Lymphoma
- Conditions
- Lymphoma
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-09-17
- Lead Sponsor
- German Low Grade Lymphoma Study Group
- Registration Number
- NCT00016887
- Locations
- ๐ง๐ช
AZ Sint-Jan, Brugge, Belgium
๐ฎ๐นOspedale Civile Alessandria, Alessandria, Italy
Combination Chemotherapy Followed by Surgery in Treating Infants With Newly Diagnosed Neuroblastoma.
- Conditions
- Neuroblastoma
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-09-17
- Lead Sponsor
- European Infant Neuroblastoma Study Group - 1999
- Registration Number
- NCT00025597
- Locations
- ๐ฆ๐น
St. Anna Children's Hospital, Vienna, Austria
๐ณ๐ดRikshospitalet University Hospital, Oslo, Norway
๐ฌ๐งBristol Royal Hospital for Children, Bristol, England, United Kingdom
Drug Development Updates
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