Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Cyclophosphamide is indicated for the treatment of malignant lymphomas, multiple myeloma, leukemias, mycosis fungoides (advanced disease), neuroblastoma (disseminated disease), adenocarcinoma of the ovary, retinoblastoma, and carcinoma of the breast. It is also indicated for the treatment of biopsy-proven minimal change nephrotic syndrome in pediatric patients.
Memorial Sloan Kettering Cancer Center, New York, New York, United States
M D Anderson Cancer Center, Houston, Texas, United States
St. Joseph Heritage Healthcare, Santa Rosa, California, United States
University of Miami/Sylvester at Plantation, Plantation, Florida, United States
Cancer Center of Kansas (CCK), Wichita, Kansas, United States
Grupo de Apoio ao Adolescente e a Criança com Câncer, Sao Paulo, Brazil
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
National Institutes of Health Clinical Center, Bethesda, Maryland, United States
The Comprehensive Cancer Center of Nanjing Drum Tower Hospital, Nanjing, Jiangsu, China
Peking Union Medical College Hospital, Beijing, Beijing, China
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States
MD Anderson Cancer Center, Houston, Texas, United States
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