Apomorphine
- Generic Name
- Apomorphine
- Brand Names
- Apokyn
- Drug Type
- Small Molecule
- Chemical Formula
- C17H17NO2
- CAS Number
- 58-00-4
- Unique Ingredient Identifier
- N21FAR7B4S
- Background
Apomorphine is a non-ergoline dopamine D2 agonist indicated to treat hypomobility associated with Parkinson's. It was first synthesized in 1845 and first used in Parkinson's disease in 1884. Apomorphine has also been investigated as an emetic, a sedative, a treatment for alcoholism, and a treatment of other movement disorders.
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- Indication
Apomorphine is indicated to treat acute, intermittent treatment of hypomobility, off episodes associated with advanced Parkinson's disease.
- Associated Conditions
- Mobility decreased
- Associated Therapies
- -
Monocentric, Prospective Study to Assess the Pharmacokinetic Profile of Continuous and Diurnal Subcutaneous Apomorphine Infusion in Patients With Parkinson's Disease
- First Posted Date
- 2021-05-14
- Last Posted Date
- 2024-04-16
- Lead Sponsor
- Rennes University Hospital
- Target Recruit Count
- 20
- Registration Number
- NCT04887467
- Locations
- 🇫🇷
CHU Pontchaillou, Rennes, France
Subcutaneous Apomorphine in the Treatment of Progressive Supranuclear Palsy and Cortico Basal Degeneration (APOPARKA)
- Conditions
- First Posted Date
- 2021-03-08
- Last Posted Date
- 2021-03-08
- Lead Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
- Target Recruit Count
- 7
- Registration Number
- NCT04786158
- Locations
- 🇫🇷
Hôpital Fondation Adolphe de Rothschild, Paris, Ile-de-France, France
Evaluation of the Nonmotor Symptomatology of Parkinsonian Patients Treated With Two Strategies Related to Apomorphine Pump Therapy in French Hospitals
- Conditions
- Interventions
- First Posted Date
- 2018-10-03
- Last Posted Date
- 2023-11-27
- Lead Sponsor
- Rennes University Hospital
- Target Recruit Count
- 43
- Registration Number
- NCT03693872
- Locations
- 🇫🇷
CH Caremeau, Nîmes, France
🇫🇷CHU La Pitié Salpêtrière, Paris, France
🇫🇷Hôpital Gui de Chauliac, Montpellier, France
A Study That Compares the Extent to Which Apomorphine Becomes Available in the Body After Taking Either an Investigational Drug Containing Apomorphine or Apomorphine That is Injected Under the Skin in People With PD Complicated by "OFF" Episodes
- First Posted Date
- 2017-09-25
- Last Posted Date
- 2020-08-13
- Lead Sponsor
- Sumitomo Pharma America, Inc.
- Target Recruit Count
- 8
- Registration Number
- NCT03292016
- Locations
- 🇺🇸
Parkinson's Disease and Movement Disorders Center of Boca Raton, Boca Raton, Florida, United States
🇺🇸Parkinson's Disese Treatment Center of SW Florida, Port Charlotte, Florida, United States
🇺🇸QUEST Research Institute, Farmington Hills, Michigan, United States
The Effects of Apomorphine on Experimental and Clinical Pain in Patients With Chronic Radicular Pain
- First Posted Date
- 2016-11-21
- Last Posted Date
- 2016-11-22
- Lead Sponsor
- Rambam Health Care Campus
- Target Recruit Count
- 59
- Registration Number
- NCT02969629
- Locations
- 🇮🇱
Rambam Health Care Campus, Haifa, Israel
Effect of Continuous Apomorphine During the Night on Sleep Disorders in Insomniac Patients With Parkinson's Disease
- First Posted Date
- 2016-10-21
- Last Posted Date
- 2024-04-25
- Lead Sponsor
- Clinique Beau Soleil
- Target Recruit Count
- 45
- Registration Number
- NCT02940912
- Locations
- 🇫🇷
Chu Ponchaillou, Rennes, France
🇫🇷Hôpital CIVIL, Strasbourg, France
🇫🇷Hôpital de HAUTEPIERRE, Strasbourg, France
Apomorphine Pump in Early Stage of Parkinson's Disease (EARLY-PUMP)
- Conditions
- Interventions
- First Posted Date
- 2016-08-11
- Last Posted Date
- 2023-11-27
- Lead Sponsor
- Rennes University Hospital
- Target Recruit Count
- 134
- Registration Number
- NCT02864004
- Locations
- 🇫🇷
Clermont-Ferrand University Hospital, Clermont-Ferrand, France
🇫🇷Lille University Hospital, Lille, France
🇫🇷Amiens University Hospital, Amiens, France
Apomorphine in Parkinson's Disease Patients With Visual Hallucinations
- Conditions
- Interventions
- First Posted Date
- 2016-03-08
- Last Posted Date
- 2017-05-03
- Lead Sponsor
- University Medical Center Groningen
- Target Recruit Count
- 35
- Registration Number
- NCT02702076
- Locations
- 🇳🇱
Department of Neurology, Groningen, Netherlands
Effect of an Apomorphine Pump on the Quality of Sleep in Parkinson's Disease Patients (POMPRENELLE).
- First Posted Date
- 2016-02-23
- Last Posted Date
- 2018-03-26
- Lead Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
- Target Recruit Count
- 15
- Registration Number
- NCT02688465
- Locations
- 🇫🇷
Fondation ophtalmique Adolphe de Rothschild, Paris, France
Outpatient Physical Therapy Intervention in Subjects With Parkinson's Disease Currently Using APOKYN®
- Conditions
- Interventions
- First Posted Date
- 2015-09-15
- Last Posted Date
- 2023-09-01
- Target Recruit Count
- 13
- Registration Number
- NCT02549573
Drug Development Updates
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