Ranolazine
- Generic Name
- Ranolazine
- Brand Names
- Aspruzyo Sprinkle, Ranexa, Ranexa (previously Latixa)
- Drug Type
- Small Molecule
- Chemical Formula
- C24H33N3O4
- CAS Number
- 95635-55-5
- Unique Ingredient Identifier
- A6IEZ5M406
- Background
Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities. Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms. With a mechanism of action different from drug...
- Indication
Ranolazine is indicated for the treatment of chronic angina. It can be used alone or in conjunction with nitrates, beta-blockers, angiotensin receptor blockers, anti-platelet drugs, calcium channel blockers, lipid-lowering drugs, and ACE inhibitors.
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- Associated Conditions
- Chronic Angina, Ventricular Arrhythmia
- Associated Therapies
- -
A Phase 1 Study to Assess the Effect of Severe Renal Impairment on the Pharmacokinetics, as Well as Safety/Tolerability, of Ranolazine
- First Posted Date
- 2012-08-30
- Last Posted Date
- 2012-12-06
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 4
- Registration Number
- NCT01675973
- Locations
- 🇺🇸
Clinical Pharmacology of Miami, Miami, Florida, United States
Long-term Efficacy Study of Sodium Channel Blocker in LQT3 Patients
- First Posted Date
- 2012-07-24
- Last Posted Date
- 2022-04-07
- Lead Sponsor
- University of Rochester
- Target Recruit Count
- 25
- Registration Number
- NCT01648205
- Locations
- 🇺🇸
University of Rochester, Rochester, New York, United States
Randomized Double Blind Control Trial on Effects of Ranolazine on New Onset Atrial Fibrillation
- Conditions
- Interventions
- First Posted Date
- 2012-05-03
- Last Posted Date
- 2017-03-23
- Lead Sponsor
- Northwell Health
- Target Recruit Count
- 54
- Registration Number
- NCT01590979
- Locations
- 🇺🇸
Staten Island University Hosptial, Staten Island, New York, United States
Safety of Amiodarone and Ranolazine Together in Patients With Angina
- Conditions
- Interventions
- First Posted Date
- 2012-03-20
- Last Posted Date
- 2012-03-21
- Lead Sponsor
- Cardiovascular Consultants of Nevada
- Target Recruit Count
- 50
- Registration Number
- NCT01558830
- Locations
- 🇺🇸
Cardiovascular Consultants of Nevada, Las Vegas, Nevada, United States
A Phase 3 Study of Ranolazine in Subjects With Type 2 Diabetes Who Are Inadequately Controlled on Metformin Alone
- Conditions
- Interventions
- First Posted Date
- 2012-03-15
- Last Posted Date
- 2014-09-23
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 442
- Registration Number
- NCT01555164
- Locations
- 🇺🇸
New Phase Research & Development, Knoxville, Tennessee, United States
🇺🇸National Research Institute, Los Angeles, California, United States
🇺🇸Baptist Diabetes Associates, Miami, Florida, United States
Single Cohort 4-period Study to Assess Pharmacokinetics of Metformin Alone and in Combination With Ranolazine
- First Posted Date
- 2012-03-07
- Last Posted Date
- 2012-07-11
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 24
- Registration Number
- NCT01546597
- Locations
- 🇺🇸
Cetero Research, San Antonio, Texas, United States
Single Cohort, 2-Period Study to Assess Pharmacokinetics of Metformin Alone and in Combination With Ranolazine 500 mg
- First Posted Date
- 2012-03-07
- Last Posted Date
- 2012-07-11
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 25
- Registration Number
- NCT01546558
- Locations
- 🇺🇸
SeaView Research Inc., Miami, Florida, United States
Ranolazine in Atrial Fibrillation Following An ELectricaL CardiOversion
- First Posted Date
- 2012-02-17
- Last Posted Date
- 2014-08-19
- Lead Sponsor
- Menarini Group
- Target Recruit Count
- 241
- Registration Number
- NCT01534962
- Locations
- 🇩🇪
Universitätsmedizin Göttingen (UMG), Kardiologie und Pneumologie, Goettingen, Lower Saxony, Germany
🇮🇹FONDAZIONE IRCCS, Dip. Cardiotoracovascolare (U.C.C.), Pavia, Lombardy, Italy
🇪🇸Hospital Clínic i Provincial de Barcelona, Servicio de Cardiología-Sección de Arritmias, Barcelona, Catalonia, Spain
Study to Evaluate the Effect of Ranolazine and Dronedarone When Given Alone and in Combination in Patients With Paroxysmal Atrial Fibrillation
- Conditions
- Interventions
- First Posted Date
- 2012-01-31
- Last Posted Date
- 2020-11-06
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 134
- Registration Number
- NCT01522651
- Locations
- 🇬🇧
Investigational Site, London, England, United Kingdom
The Effects of Ranolazine on Exercise Capacity in Patients With Heart Failure With Preserved Ejection Fraction
- Conditions
- Interventions
- First Posted Date
- 2012-01-06
- Last Posted Date
- 2020-01-18
- Lead Sponsor
- University of California, San Diego
- Target Recruit Count
- 10
- Registration Number
- NCT01505179
- Locations
- 🇺🇸
University of California, San Diego, San Diego, California, United States
Drug Development Updates
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