Tioguanine

Generic Name
Tioguanine
Brand Names
Lanvis, Tabloid
Drug Type
Small Molecule
Chemical Formula
C5H5N5S
CAS Number
154-42-7
Unique Ingredient Identifier
WIX31ZPX66
Background

An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.

Indication

For remission induction and remission consolidation treatment of acute nonlymphocytic leukemias.

Associated Conditions
Acute Non-Lymphocytic Leukemia, Nonlymphocytic Acute myeloid leukemia
Associated Therapies
-
Clinical Trials
Related News

Augmented Berlin-Frankfurt-Munster Therapy Plus Ofatumumab for Young Adults With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

First Posted Date
2015-04-17
Last Posted Date
2018-06-11
Lead Sponsor
M.D. Anderson Cancer Center
Target Recruit Count
1
Registration Number
NCT02419469
Locations
🇺🇸

University of Texas MD Anderson Cancer Center, Houston, Texas, United States

Study of 6-Thioguanine in Combination With 6-Mercaptopurine During Maintenance Therapy of Childhood Lymphoma

Phase 1
Withdrawn
Conditions
Non-Hodgkin Lymphoma
Interventions
Drug: 6-thioguanine
First Posted Date
2014-05-19
Last Posted Date
2016-10-07
Lead Sponsor
Kjeld Schmiegelow
Registration Number
NCT02141100
Locations
🇩🇰

Dept. of Pediatric Oncology, JMC, Rigshospitalet, Copenhagen, Denmark

Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma

Phase 3
Active, not recruiting
Conditions
Adult T Acute Lymphoblastic Leukemia
Ann Arbor Stage II Adult Lymphoblastic Lymphoma
Ann Arbor Stage II Childhood Lymphoblastic Lymphoma
Ann Arbor Stage III Adult Lymphoblastic Lymphoma
Ann Arbor Stage III Childhood Lymphoblastic Lymphoma
Ann Arbor Stage IV Adult Lymphoblastic Lymphoma
Ann Arbor Stage IV Childhood Lymphoblastic Lymphoma
Childhood T Acute Lymphoblastic Leukemia
Interventions
Drug: Cyclophosphamide
Drug: Bortezomib
Drug: Cytarabine
Drug: Daunorubicin
Drug: Daunorubicin Hydrochloride
Drug: Dexamethasone
Drug: Doxorubicin
Drug: Doxorubicin Hydrochloride
Drug: Etoposide
Drug: Hydrocortisone Sodium Succinate
Drug: Ifosfamide
Drug: Leucovorin Calcium
Drug: Mercaptopurine
Drug: Methotrexate
Drug: Pegaspargase
Radiation: Radiation Therapy
Drug: Thioguanine
Drug: Vincristine Sulfate
Drug: Vincristine
First Posted Date
2014-04-14
Last Posted Date
2024-11-13
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
847
Registration Number
NCT02112916
Locations
🇺🇸

Covenant Children's Hospital, Lubbock, Texas, United States

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UMC Cancer Center / UMC Health System, Lubbock, Texas, United States

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Monash Medical Center-Clayton Campus, Clayton, Victoria, Australia

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Blinatumomab in Treating Younger Patients With Relapsed B-cell Acute Lymphoblastic Leukemia

First Posted Date
2014-04-02
Last Posted Date
2024-11-13
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
669
Registration Number
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Locations
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Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland, United States

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NYP/Weill Cornell Medical Center, New York, New York, United States

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State University of New York Upstate Medical University, Syracuse, New York, United States

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NHL16: Study For Newly Diagnosed Patients With Acute Lymphoblastic Lymphoma

First Posted Date
2011-10-13
Last Posted Date
2022-06-28
Lead Sponsor
St. Jude Children's Research Hospital
Target Recruit Count
23
Registration Number
NCT01451515
Locations
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Rady Children's Hospital San Diego, San Diego, California, United States

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St. Jude Children's Research Hospital, Memphis, Tennessee, United States

Clofarabine or High-Dose Cytarabine and Pegaspargase in Children with ALL

First Posted Date
2010-10-26
Last Posted Date
2024-12-11
Lead Sponsor
Universitätsklinikum Hamburg-Eppendorf
Target Recruit Count
745
Registration Number
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Locations
🇩🇪

Universitaetsklinikum Duesseldorf, Duesseldorf, Germany

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University Medical Center Hamburg - Eppendorf, Hamburg, Germany

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Johannes Gutenberg University, Mainz, Germany

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Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma

First Posted Date
2010-08-30
Last Posted Date
2024-02-08
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Target Recruit Count
9350
Registration Number
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Locations
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Valley Children's Hospital, Madera, California, United States

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University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland, United States

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UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California, United States

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Combination Chemotherapy in Treating Young Adult Patients With Acute Lymphoblastic Leukemia

Not Applicable
Completed
Conditions
Leukemia
First Posted Date
2010-07-05
Last Posted Date
2021-09-13
Lead Sponsor
Gruppo Italiano Malattie EMatologiche dell'Adulto
Target Recruit Count
76
Registration Number
NCT01156883
Locations
🇮🇹

Azienda Ospedaliera - Nuovo Ospedale "Torrette", Ancona, Italy

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USL 8 - Ospedale S.Donato, Arezzo, Italy

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International Collaborative Treatment Protocol For Children And Adolescents With Acute Lymphoblastic Leukemia

First Posted Date
2010-05-05
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2022-05-24
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Registration Number
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Locations
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A.oe. Landeskrankenhaus Klagenfurt, Abt. für Kinder- und Jugendheilkunde, Klagenfurt, Austria

🇨🇿

University Hospital Brno, Department of Pediatric Oncology, Brno, Czechia

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Klinikum Berlin-Buch II. Kinderklinik, Bereich Onkologie/Allg. Pädiatrie, Berlin, Germany

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Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia (Closed to Accrual 4-22-2011)

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2009-03-20
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2021-04-27
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Children's Hospital Los Angeles, Los Angeles, California, United States

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Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston, Texas, United States

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