Tioguanine
- Generic Name
- Tioguanine
- Brand Names
- Lanvis, Tabloid
- Drug Type
- Small Molecule
- Chemical Formula
- C5H5N5S
- CAS Number
- 154-42-7
- Unique Ingredient Identifier
- WIX31ZPX66
- Background
An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
- Indication
For remission induction and remission consolidation treatment of acute nonlymphocytic leukemias.
- Associated Conditions
- Acute Non-Lymphocytic Leukemia, Nonlymphocytic Acute myeloid leukemia
- Associated Therapies
- -
Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia
- Conditions
- Interventions
- Drug: asparaginaseDrug: cyclophosphamideDrug: cytarabineDrug: daunorubicin hydrochlorideDrug: dexamethasoneDrug: doxorubicin hydrochlorideDrug: ifosfamideDrug: etoposideDrug: mercaptopurineDrug: methotrexateDrug: prednisoneDrug: thioguanineDrug: vincristine sulfateDrug: vindesineRadiation: radiation therapy
- First Posted Date
- 2007-02-01
- Last Posted Date
- 2013-05-29
- Lead Sponsor
- University Hospital Schleswig-Holstein
- Target Recruit Count
- 4559
- Registration Number
- NCT00430118
- Locations
- 🇦🇹
LKH Leoben, Leoben, Austria
🇦🇹Landeskrankenhaus Feldkirch, Feldkirch-Tisis, Austria
🇦🇹Universitaet Kinderklinik, Graz, Austria
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma
- Conditions
- Interventions
- Other: Laboratory Biomarker AnalysisDrug: CyclophosphamideDrug: AsparaginaseDrug: Daunorubicin HydrochlorideDrug: CytarabineDrug: MercaptopurineDrug: Leucovorin CalciumDrug: DexamethasoneDrug: PegaspargaseDrug: Doxorubicin HydrochlorideDrug: MethotrexateDrug: NelarabineDrug: PrednisoneDrug: Vincristine SulfateRadiation: Radiation TherapyDrug: Thioguanine
- First Posted Date
- 2006-12-05
- Last Posted Date
- 2024-10-21
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 1895
- Registration Number
- NCT00408005
- Locations
- 🇺🇸
Scott and White Memorial Hospital, Temple, Texas, United States
🇺🇸Henry Ford Health Saint John Hospital, Detroit, Michigan, United States
🇺🇸Children's Hospital of Alabama, Birmingham, Alabama, United States
Combination Chemotherapy in Treating Young Patients With Down Syndrome and Acute Myeloid Leukemia or Myelodysplastic Syndromes
- Conditions
- Childhood Acute Erythroleukemia (M6)Childhood Acute Megakaryocytic Leukemia (M7)Childhood Acute Minimally Differentiated Myeloid Leukemia (M0)Childhood Acute Basophilic LeukemiaChildhood Acute Myeloblastic Leukemia With Maturation (M2)Childhood Acute Eosinophilic LeukemiaChildhood Acute Monocytic Leukemia (M5b)Childhood Acute Myelomonocytic Leukemia (M4)Childhood Myelodysplastic Syndromesde Novo Myelodysplastic Syndromes
- Interventions
- First Posted Date
- 2006-08-29
- Last Posted Date
- 2022-01-28
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 205
- Registration Number
- NCT00369317
- Locations
- 🇺🇸
Nationwide Children's Hospital, Columbus, Ohio, United States
🇺🇸Johns Hopkins University-Sidney Kimmel Cancer Center, Baltimore, Maryland, United States
🇨🇦Hospital for Sick Children, Toronto, Ontario, Canada
Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia
- Conditions
- First Posted Date
- 2006-06-23
- Last Posted Date
- 2013-08-26
- Lead Sponsor
- Universitätsklinikum Hamburg-Eppendorf
- Target Recruit Count
- 550
- Registration Number
- NCT00343369
- Locations
- 🇩🇪
Dr. von Haunersches Kinderspital der Universitaet Muenchen, Munich, Germany
🇩🇪Kreskrankenhaus Kinderabteilung, Heide, Germany
🇩🇪Universitaets - Kinderklinik, Leipzig, Germany
Prednisolone or Dexamethasone Combined With Chemotherapy in Treating Young Patients With Newly Diagnosed Lymphoblastic Lymphoma
- Conditions
- First Posted Date
- 2006-01-11
- Last Posted Date
- 2013-07-10
- Lead Sponsor
- Children's Cancer and Leukaemia Group
- Target Recruit Count
- 600
- Registration Number
- NCT00275106
- Locations
- 🇬🇧
Addenbrooke's Hospital, Cambridge, England, United Kingdom
🇬🇧Royal Manchester Children's Hospital, Manchester, England, United Kingdom
🇩🇪Kinderklinik, Giessen, Germany
Biology and Treatment Strategy of AML in Its Subgroups: Multicenter Randomized Trial by the German Acute Myeloid Leukemia Cooperative Group (AMLCG)
- Conditions
- First Posted Date
- 2005-12-15
- Last Posted Date
- 2012-10-26
- Lead Sponsor
- University Hospital Muenster
- Target Recruit Count
- 3500
- Registration Number
- NCT00266136
- Locations
- 🇩🇪
University of Muenster, Medical Center, Department of Medicine, Hematology and Oncology, Muenster, Germany
German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults
- Conditions
- First Posted Date
- 2005-09-20
- Last Posted Date
- 2010-08-23
- Lead Sponsor
- Johann Wolfgang Goethe University Hospital
- Target Recruit Count
- 75
- Registration Number
- NCT00199017
- Locations
- 🇩🇪
University Hospital, Medical Dept. II, Frankfurt, Germany
German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003)
- Conditions
- Interventions
- Drug: CyclophosphamideDrug: DexamethasoneDrug: VincristineDrug: DaunorubicinDrug: AsparaginaseDrug: MethotrexateDrug: CytarabineDrug: MercaptopurineDrug: G-CSFDrug: VindesineDrug: EtoposideDrug: PrednisoloneDrug: AdriamycinDrug: ThioguanineDrug: TeniposideProcedure: CNS irradiationProcedure: Mediastinal IrradiationProcedure: Stem cell transplantation (SCT)Drug: IdarubicinDrug: FludarabineDrug: Cladribine
- First Posted Date
- 2005-09-20
- Last Posted Date
- 2022-08-18
- Lead Sponsor
- Goethe University
- Target Recruit Count
- 1883
- Registration Number
- NCT00198991
- Locations
- 🇩🇪
University of Frankfurt, Medical Dept. II, Frankfurt, Germany
German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93)
- Conditions
- First Posted Date
- 2005-09-20
- Last Posted Date
- 2023-03-17
- Lead Sponsor
- Goethe University
- Target Recruit Count
- 720
- Registration Number
- NCT00199069
- Locations
- 🇩🇪
University Hospital, Medical Dept. II, Frankfurt, Germany
Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab
- Conditions
- First Posted Date
- 2005-09-20
- Last Posted Date
- 2010-08-23
- Lead Sponsor
- Johann Wolfgang Goethe University Hospital
- Target Recruit Count
- 60
- Registration Number
- NCT00199004
- Locations
- 🇩🇪
University Hospital of Frankfurt, Medical Dept. II, Frankfurt, Germany
Drug Development Updates
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