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Triptorelin

Generic Name
Triptorelin
Brand Names
Decapeptyl, Trelstar, Triptodur
Drug Type
Small Molecule
Chemical Formula
C64H82N18O13
CAS Number
57773-63-4
Unique Ingredient Identifier
9081Y98W2V

Overview

Triptorelin is a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH). Possessing greater potency than endogenous LHRH, triptorelin reversibly represses gonadotropin secretion. After chronic, continuous administration, this agent effects sustained decreases in LH and FSH production and testicular and ovarian steroidogenesis. Serum testosterone concentrations may fall to levels typically observed in surgically castrated men.

Indication

Triptorelin is indicated for the palliative treatment of advanced prostate cancer.

Associated Conditions

  • Advanced Prostate Cancer

Clinical Trials

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Title
Posted
Study ID
Phase
Status
Sponsor
Can GnRH Agonist Trigger Prevent Ovarian Hyperstimulation Syndrome?
2012/10/26
NCT01714648
Phase 4
Terminated
Elisha Hospital
Induction and Maintenance of Castration After Subcutaneous Injections of Triptorelin Pamoate in Patients With Prostate Cancer
2012/10/26
NCT01715129
Phase 3
Completed
Ipsen
GP Extended Action Triptorelin
2012/08/28
NCT01673984
Phase 4
Terminated
Ipsen
Study on Efficacy, Pharmacokinetics, and Safety of Two Subcutaneous Injections of Triptorelin Embonate 6 Month Formulation in Patients With Advanced Prostate Cancer
2012/08/02
NCT01656161
Phase 3
Completed
Debiopharm International SA
Final Oocyte Maturation Via Administration of GnRH Agonists Followed By Luteal Support With hCG
2012/07/11
NCT01638026
Phase 4
Completed
HaEmek Medical Center, Israel
Trial Comparing hCG Triggering Versus hCG Associated With GnRH Agonist
2012/05/30
NCT01607203
Phase 4
Completed
AZ Jan Palfijn Gent
The Effect of Pre-treatment With GnRH Analogues Prior in Vitro Fertilization in Patients With Endometriosis
2012/04/20
NCT01581359
Phase 4
Completed
Instituto de Investigacion Sanitaria La Fe
Endometrial Receptivity After GnRH Agonist Triggering
2011/12/29
NCT01500863
Phase 4
Completed
IVI Madrid
Efficacy, Safety, and Pharmacokinetics (PK) of Triptorelin 6-month Formulation in Patients With Central Precocious Puberty
2011/11/09
NCT01467882
Phase 3
Completed
Debiopharm International SA
Ovarian Stimulation Using Recombinant Follicle-stimulating Hormone (FSH) and Gonadotrophin Releasing Hormone (GnRH) Agonist in Alternate Days
2011/11/09
NCT01468441
Not Applicable
Completed
Fertility - Assisted Fertilization Center

FDA Drug Approvals

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