Eplerenone

Generic Name
Eplerenone
Brand Names
Inspra
Drug Type
Small Molecule
Chemical Formula
C24H30O6
CAS Number
107724-20-9
Unique Ingredient Identifier
6995V82D0B
Background

Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the ef...

Indication

For improvement of survival of stable patients with left ventricular systolic dysfunction (ejection fraction <40%) and clinical evidence of congestive heart failure after an acute myocardial infarction.

Associated Conditions
Hypertension, LVEF <40% Congestive heart failure, Chronic heart failure with reduced ejection fraction (NYHA Class II)
Associated Therapies
-

Eplerenone and Aliskiren Research Targeting Hypertensive Patients With Left Ventricular Hypertrophy

First Posted Date
2013-07-09
Last Posted Date
2013-07-22
Lead Sponsor
Nagoya University
Target Recruit Count
100
Registration Number
NCT01893788
Locations
🇯🇵

Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan

Aldosterone Antagonism and Microvascular Function

First Posted Date
2013-06-26
Last Posted Date
2018-11-05
Lead Sponsor
Maastricht University Medical Center
Target Recruit Count
25
Registration Number
NCT01887119
Locations
🇳🇱

Maastricht University, Maastricht, Limburg, Netherlands

PHOspholamban RElated CArdiomyopathy STudy - Intervention

First Posted Date
2013-05-20
Last Posted Date
2021-10-18
Lead Sponsor
M.p. van den Berg, MD, PhD, professor in Cardiology
Target Recruit Count
84
Registration Number
NCT01857856
Locations
🇳🇱

Antonius ziekenhuis Sneek, Sneek, Friesland, Netherlands

🇳🇱

UMCG, Groningen, Netherlands

🇳🇱

UMCU, Utrecht, Netherlands

and more 1 locations

Eplerenone and Extracellular Adenosine Formation

Phase 4
Completed
Conditions
Interventions
First Posted Date
2013-04-22
Last Posted Date
2014-01-09
Lead Sponsor
Radboud University Medical Center
Target Recruit Count
14
Registration Number
NCT01837108
Locations
🇳🇱

Radboud University Medical Centre, Nijmegen, Gelderland, Netherlands

EPLErenone in CsA-Treated Recipients (EpleCsAT): Safety

First Posted Date
2013-04-18
Last Posted Date
2013-04-18
Lead Sponsor
CHU de Reims
Target Recruit Count
31
Registration Number
NCT01834768
Locations
🇫🇷

Centre Hospitalier Universitaire de Reims, Reims, France

The EPOCH Study (Eplerenone on Top of ACE Inhibition in Chronic Kidney Disease Patients With Hypertension)

Not Applicable
Conditions
Interventions
First Posted Date
2013-04-16
Last Posted Date
2020-06-19
Lead Sponsor
Medical University of Vienna
Target Recruit Count
24
Registration Number
NCT01832558
Locations
🇦🇹

Medical University of Vienna, Vienna, Austria

Eplerenone Versus Spironolactone as Treatment of Ascites Due to Liver Cirrhosis; a Study of Efficacy and Side Effects

Phase 2
Withdrawn
Conditions
Interventions
First Posted Date
2013-02-28
Last Posted Date
2016-01-15
Lead Sponsor
Emma Nilsson
Registration Number
NCT01801228
Locations
🇸🇪

University Hospital of Skane, Lund, Skane, Sweden

Detection of Diffuse Scar in Patients With Diabetes

First Posted Date
2013-02-18
Last Posted Date
2013-02-18
Lead Sponsor
Brigham and Women's Hospital
Target Recruit Count
50
Registration Number
NCT01794091
Locations
🇺🇸

Brigham and Women's Hospital, Boston, Massachusetts, United States

Effect of Eplerenone on Postprandial Inflammatory Response in Healthy Adults

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2013-02-08
Last Posted Date
2017-05-17
Lead Sponsor
Brigham and Women's Hospital
Target Recruit Count
16
Registration Number
NCT01786551
Locations
🇺🇸

Brigham and Women's Hospital, Boston, Massachusetts, United States

Study of the Effect of Eplerenone on Heart Function in Women Receiving Anthracycline Chemotherapy for Breast Cancer

Phase 2
Terminated
Conditions
Interventions
First Posted Date
2012-10-17
Last Posted Date
2017-01-05
Lead Sponsor
University of British Columbia
Target Recruit Count
44
Registration Number
NCT01708798
Locations
🇨🇦

British Columbia Cancer Agency, Vancouver Centre, Vancouver, British Columbia, Canada

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