MedPath

Selenomethionine

Generic Name
Selenomethionine
Drug Type
Small Molecule
Chemical Formula
C5H11NO2Se
CAS Number
3211-76-5
Unique Ingredient Identifier
964MRK2PEL
Background

Selenomethionine is a naturally occuring amino acid in some plant materials such as cereal grains, soybeans and enriched yeast but it cannot be synthesized from animals or humans. It can be produced from post-structural modifications. In vivo, selenomethionine plays an essential role in acting as an antioxidant, where it depletes reactive oxygen species (ROS) and aids in the formation and recycling of glutathione, another important antioxidant. In comparison to selenite, which is the inorganic form of selenium, the organic form of selenomethionine is more readily absorbed in the human body. Selenomethionin is used in biochemical laboratories where its incorporation into proteins that need to be visualized enhances the performance of X-ray crystallography.

Seleno-L Methionine (SLM)-Axitinib-Pembrolizumab

Phase 1
Recruiting
Conditions
Clear Cell Renal Cell Carcinoma
Clear Cell Renal Cell Carcinoma Metastatic
Interventions
First Posted Date
2022-05-06
Last Posted Date
2025-03-10
Lead Sponsor
Mohammed Milhem
Target Recruit Count
55
Registration Number
NCT05363631
Locations
🇺🇸

University of Iowa Hospitals & Clinics, Iowa City, Iowa, United States

Optimal Selenium for Bowel Polyps (OSCAR)

Phase 1
Completed
Conditions
Colorectal Adenoma
Interventions
First Posted Date
2021-07-07
Last Posted Date
2025-01-22
Lead Sponsor
University of Auckland, New Zealand
Target Recruit Count
56
Registration Number
NCT04952129
Locations
🇳🇿

Counties Manukau DHB, Auckland, New Zealand

🇳🇿

Waikato DHB, Hamilton, Waikato, New Zealand

SLM + Axitinib for Clear Cell RCC

Phase 1
Completed
Conditions
Advanced Metastatic Clear Cell Renal Cell Carcinoma (CCRCC)
Interventions
First Posted Date
2015-08-28
Last Posted Date
2025-05-20
Lead Sponsor
Mohammed Milhem
Target Recruit Count
46
Registration Number
NCT02535533
Locations
🇺🇸

University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States

Colon Cancer Prevention Using Selenium

Early Phase 1
Conditions
Prevention of Colorectal Cancer
Interventions
First Posted Date
2010-09-29
Last Posted Date
2010-09-29
Lead Sponsor
University of Illinois at Chicago
Target Recruit Count
50
Registration Number
NCT01211561
Locations
🇺🇸

University of Illinois at Chicago Medical Center, Chicago, Illinois, United States

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