Lysine
- Generic Name
- Lysine
- Brand Names
- Aminosyn II 7 %, Sulfite-free, Aminosyn-PF 7%, Clinimix 2.75/5, Clinimix E 2.75/5, Clinisol 15, Freamine 6.9, Freamine III 10, Hepatamine 8, Nephramine, Olimel, Periolimel, Plenamine, Premasol, Primene, Procalamine 3, Prosol, Travasol 10, Trophamine 10 %
- Drug Type
- Small Molecule
- Chemical Formula
- C6H14N2O2
- CAS Number
- 56-87-1
- Unique Ingredient Identifier
- K3Z4F929H6
- Background
Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ε-amino group acts as a site for hydrogen binding and a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.
- Indication
Supplemental lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity.
- Associated Conditions
- Weight Loss
- Associated Therapies
- Weight Gain, Amino acid supplementation
Determinants of Alpha-aminoadipic Acid (2-AAA) and Relationship to Diabetes: Study 3
- First Posted Date
- 2022-01-27
- Last Posted Date
- 2024-06-05
- Lead Sponsor
- Vanderbilt University Medical Center
- Target Recruit Count
- 23
- Registration Number
- NCT05210504
- Locations
- 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States
The Effect of Acute Lysine Administration on α-aminoadipic Acid
- First Posted Date
- 2016-04-29
- Last Posted Date
- 2017-02-07
- Lead Sponsor
- Vanderbilt University
- Target Recruit Count
- 13
- Registration Number
- NCT02756117
The Effect of L-lysine on Human Gastrointestinal Secretion: A Dose-finding Study Applying Magnetic Resonance Imaging (MRI)
- First Posted Date
- 2012-04-18
- Last Posted Date
- 2015-05-28
- Lead Sponsor
- University of Zurich
- Target Recruit Count
- 6
- Registration Number
- NCT01579799
- Locations
- 🇨🇭
University Hospital Zurich, Gastroenterology, Zurich, ZH, Switzerland
An Exploratory Open Label Study of Adjunctive L-lysine Treatment in Patients With Schizophrenia
- First Posted Date
- 2009-10-16
- Last Posted Date
- 2009-10-16
- Lead Sponsor
- Göteborg University
- Target Recruit Count
- 10
- Registration Number
- NCT00996242
- Locations
- 🇸🇪
Sahlgrenska Univeristy Hospital, Gothenburg, Sweden
Drug Development Updates
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