Overview
Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ε-amino group acts as a site for hydrogen binding and a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.
Indication
Supplemental lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity.
Associated Conditions
- Weight Loss
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2024/08/30 | Phase 2 | Recruiting | |||
2024/04/23 | Phase 1 | Recruiting | |||
2022/01/27 | Phase 1 | Completed | |||
2018/02/27 | Early Phase 1 | Completed | |||
2018/02/22 | Early Phase 1 | Recruiting | |||
2017/02/24 | Phase 1 | Completed | |||
2016/10/11 | Phase 2 | UNKNOWN | Fundacion Investigacion Interhospitalaria Cardiovascular | ||
2016/04/29 | Phase 1 | Completed | |||
2014/09/17 | Phase 1 | Completed | David Vivas | ||
2013/09/05 | Phase 4 | UNKNOWN | Azienda Ospedaliera San Giovanni Battista |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Baxter Healthcare Corporation | 0338-0184 | INTRAVENOUS | 464 mg in 100 mL | 4/13/2021 | |
| Baxter Healthcare Company | 0338-0210 | INTRAVENOUS | 464 mg in 100 mL | 9/21/2020 | |
| Baxter Healthcare Corporation | 0338-0210 | INTRAVENOUS | 464 mg in 100 mL | 9/21/2020 | |
| Baxter Healthcare Corporation | 0338-1089 | INTRAVENOUS | 247 mg in 100 mL | 4/13/2021 | |
| Baxter Healthcare Corporation | 0338-1099 | INTRAVENOUS | 290 mg in 100 mL | 4/13/2021 | |
| ICU Medical Inc. | 0990-7171 | INTRAVENOUS | 1575 mg in 100 mL | 5/4/2022 | |
| Baxter Healthcare Corporation | 0338-0194 | INTRAVENOUS | 464 mg in 100 mL | 4/13/2021 | |
| Baxter Healthcare Company | 0338-1147 | INTRAVENOUS | 290 mg in 100 mL | 9/21/2020 | |
| Baxter Healthcare Corporation | 0338-1147 | INTRAVENOUS | 290 mg in 100 mL | 9/21/2020 | |
| Baxter Healthcare Company | 0338-1142 | INTRAVENOUS | 159 mg in 100 mL | 9/21/2020 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
Authorised | 7/25/2019 |
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| LYSAKARE SOLUTION FOR INFUSION 25G / 25G | SIN16003P | INFUSION, SOLUTION | 25 g/L | 8/31/2020 | |
| OLICLINOMEL N4-550 E EMULSION FOR INFUSION | SIN12542P | EMULSION | 1.60 g/l | 5/6/2004 | |
| SmofKabiven Emulsion for Infusion | SIN14286P | INJECTION, EMULSION | 9.3g /1000ml | 1/8/2013 | |
| KABIVEN PERIPHERAL EMULSION FOR INFUSION | SIN11718P | INJECTION | 1.9 g/l | 11/16/2001 | |
| OLICLINOMEL N7-1000 E EMULSION FOR INFUSION | SIN12539P | EMULSION | 2.90 g/l | 5/6/2004 | |
| NUTRIFLEX® OMEGA PLUS EMULSION FOR INFUSION | SIN15468P | INJECTION, EMULSION | 2.728g/1000ml | 4/23/2018 | |
| PERIOLIMEL N4E Emulsion for Infusion | SIN16888P | EMULSION | 1.99g/L | 10/20/2023 | |
| TROPHAMINE INJECTION 10% | SIN07846P | INJECTION | 0.82 g/100 ml | 9/12/1994 | |
| AMINOPLASMAL B.BRAUN 10% E SOLUTION FOR INFUSION | SIN15411P | INFUSION, SOLUTION | 8.56g/1000ml | 1/23/2018 | |
| NUTRIFLEX® OMEGA SPECIAL B. BRAUN EMULSION FOR INFUSION | SIN16734P | INJECTION, EMULSION | 3.980g/1000ml | 3/7/2023 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| Lysine Hydrochloride and Glucose Injection | 国药准字H20050211 | 化学药品 | 注射剂 | 7/17/2022 | |
| Lysine Hydrochloride and Glucose Injection | 国药准字H20050254 | 化学药品 | 注射剂 | 1/8/2021 | |
| Lysine Hydrochloride and Glucose Injection | 国药准字H20050376 | 化学药品 | 注射剂(注射液) | 8/12/2020 | |
| Lysine Hydrochloride and Glucose Injection | 国药准字H20070017 | 化学药品 | 注射剂(注射液) | 8/12/2020 | |
| Lysine Hydrochloride and Glucose Injection | 国药准字H20070083 | 化学药品 | 注射剂(注射液) | 4/13/2021 | |
| Lysine Hydrochloride and Glucose Injection | 国药准字H20060306 | 化学药品 | 注射剂 | 1/31/2023 | |
| Lysine Hydrochloride and Glucose Injection | 国药准字H20052348 | 化学药品 | 注射剂 | 6/30/2020 | |
| Lysine Hydrochloride and Glucose Injection | 国药准字H20052036 | 化学药品 | 注射剂 | 2/2/2021 | |
| Lysine Hydrochloride and Glucose Injection | 国药准字H20051874 | 化学药品 | 注射剂 | 9/29/2020 | |
| Lysine Hydrochloride Injection | 国药准字H20000554 | 化学药品 | 注射剂 | 9/26/2020 |
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| VAMINOLACT I.V. SOLUTION | N/A | N/A | N/A | 10/14/1992 | |
| PAN-AMIN G INJ | N/A | N/A | N/A | 5/17/1979 | |
| PAN-AMIN G SOLUTION FOR INFUSION 500ML | N/A | otsuka pharmaceutical (h.k.) limited | N/A | N/A | 4/5/2012 |
| NUTRINEAL PD4 SOLUTION | N/A | N/A | N/A | 9/9/1999 | |
| LA-FLAMING INJ. | N/A | N/A | N/A | 1/28/2010 | |
| OLIMEL N9E EMULSION FOR INFUSION | N/A | N/A | N/A | 10/24/2013 | |
| NUTRIFLEX OMEGA SPECIAL EMULSION FOR INFUSION | N/A | N/A | N/A | 1/11/2012 | |
| SMOFKABIVEN EMULSION FOR INFUSION | N/A | N/A | N/A | 5/26/2011 | |
| NUTRIFLEX OMEGA PLUS EMULSION FOR INFUSION | N/A | N/A | N/A | 1/11/2012 | |
| AMINOGEN-S SOLUTION FOR INFUSION | N/A | wings pharmaceutical ltd | N/A | N/A | 8/15/2013 |
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| Cellula-T oral powder jar | 43995 | Hong Sp & Hs | Medicine | A | 4/13/1993 |
| SYNTHAMIN 17 Amino acid 10% with Electrolytes and Glucose 25% 1000mL injection AHB6350 | 19609 | Medicine | A | 9/30/1991 | |
| AMINOVEN amino acid 10% solution for infusion 500 mL bottle | 117659 | Medicine | A | 10/22/2007 | |
| SMOFKABIVEN amino acids 5.1% / lipids 3.8% / glucose 12.7% / electrolytes 0.7% emulsion for intravenous infusion bag 1970 mL | 180546 | Medicine | A | 1/9/2012 | |
| Kids Multi | 329564 | Medicine | A | 2/6/2020 | |
| OLICLINOMEL N4-550 E 1000 mL IV emulsion for infusion with electrolytes bag | 136599 | Medicine | A | 9/4/2007 | |
| OLICLINOMEL N4-550 E 2500 mL IV emulsion for infusion with electrolytes bag | 141396 | Medicine | A | 9/4/2007 | |
| OLIMEL N5-860E Emulsion for intravenous infusion | 197417 | Medicine | A | 8/9/2013 | |
| Visdon BRAINBOOK Concentration Support | 371690 | Medicine | A | 7/27/2021 | |
| Olimel N12-640 emulsion for intravenous infusion bag. | 303755 | Medicine | A | 7/1/2019 |
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