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Lysine

Generic Name
Lysine
Brand Names
Aminosyn II 7 %, Sulfite-free, Aminosyn-PF 7%, Clinimix 2.75/5, Clinimix E 2.75/5, Clinisol 15, Freamine 6.9, Freamine III 10, Hepatamine 8, Nephramine, Olimel, Periolimel, Plenamine, Premasol, Primene, Procalamine 3, Prosol, Travasol 10, Trophamine 10 %
Drug Type
Small Molecule
Chemical Formula
C6H14N2O2
CAS Number
56-87-1
Unique Ingredient Identifier
K3Z4F929H6

Overview

Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ε-amino group acts as a site for hydrogen binding and a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.

Background

Lysine (abbreviated as Lys or K) is an α-amino acid with the chemical formula HO2CCH(NH2)(CH2)4NH2. This amino acid is an essential amino acid, which means that humans cannot synthesize it. Its codons are AAA and AAG. Lysine is a base, as are arginine and histidine. The ε-amino group acts as a site for hydrogen binding and a general base in catalysis. Common posttranslational modifications include methylation of the ε-amino group, giving methyl-, dimethyl-, and trimethyllysine. The latter occurs in calmodulin. Other posttranslational modifications include acetylation. Collagen contains hydroxylysine which is derived from lysine by lysyl hydroxylase. O-Glycosylation of lysine residues in the endoplasmic reticulum or Golgi apparatus is used to mark certain proteins for secretion from the cell.

Indication

Supplemental lysine has putative anti-herpes simplex virus activity. There is preliminary research suggesting that it may have some anti-osteoporotic activity.

Associated Conditions

  • Weight Loss

FDA Approved Products

CLINIMIX
Manufacturer:Baxter Healthcare Corporation
Route:INTRAVENOUS
Strength:290 mg in 100 mL
Approved: 2021/04/13
NDC:0338-1099
CLINIMIX
Manufacturer:Baxter Healthcare Corporation
Route:INTRAVENOUS
Strength:247 mg in 100 mL
Approved: 2021/04/13
NDC:0338-1091
Aminosyn II
Manufacturer:ICU Medical Inc.
Route:INTRAVENOUS
Strength:1575 mg in 100 mL
Approved: 2022/05/04
NDC:0990-7171
Premasol - sulfite-free (Amino Acid)
Manufacturer:Baxter Healthcare Corporation
Route:INTRAVENOUS
Strength:0.49 g in 100 mL
Approved: 2022/08/04
NDC:0338-1131
CLINIMIX
Manufacturer:Baxter Healthcare Corporation
Route:INTRAVENOUS
Strength:290 mg in 100 mL
Approved: 2021/04/13
NDC:0338-1101

Singapore Approved Products

LYSAKARE SOLUTION FOR INFUSION 25G / 25G
Manufacturer:LABORATOIRE BIOLUZ
Form:INFUSION, SOLUTION
Strength:25 g/L
Online:Yes
Approved: 2020/08/31
Approval:SIN16003P
OLICLINOMEL N4-550 E EMULSION FOR INFUSION
Manufacturer:BAXTER SA, Ajinomoto North America Incorporated (Intermediate)
Form:EMULSION
Strength:1.60 g/l
Online:Yes
Approved: 2004/05/06
Approval:SIN12542P
SmofKabiven Emulsion for Infusion
Manufacturer:Fresenius Kabi AB, Fresenius Kabi Austria GmbH
Form:INJECTION, EMULSION
Strength:9.3g /1000ml
Online:Yes
Approved: 2013/01/08
Approval:SIN14286P
KABIVEN PERIPHERAL EMULSION FOR INFUSION
Manufacturer:FRESENIUS KABI AB, FRESENIUS KABI AUSTRIA GMBH
Form:INJECTION
Strength:1.9 g/l
Online:Yes
Approved: 2001/11/16
Approval:SIN11718P
OLICLINOMEL N7-1000 E EMULSION FOR INFUSION
Manufacturer:BAXTER SA, Ajinomoto North America Incorporated (Intermediate)
Form:EMULSION
Strength:2.90 g/l
Online:Yes
Approved: 2004/05/06
Approval:SIN12539P

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