Polymyxin B

Polymyxin B was discovered in the 1940s. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa. Polymyxin B has a narrow therapeutic index and so its use is limited and unlikely to be used first line.

Polymyxin B was discovered in the 1940s. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa. Polymyxin B has a narrow therapeutic index and so its use is limited and unlikely to be used first line.

Polymyxin B is indicated for the treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.

• Acute Otitis Media (AOM)
• Bacteremia caused by Enterobacter aerogenes
• Bacterial Conjunctivitis
• Bacterial Infections
• Chronic Otitis Media
• Escherichia urinary tract infection
• Klebsiella bacteraemia
• Meningitis caused by Haemophilus influenzae
• Meningitis, Bacterial
• Ocular Inflammation
• Otitis Externa
• Otorrhoea
• Superficial ocular infections of the conjunctiva caused by susceptible bacteria
• Superficial ocular infections of the cornea caused by susceptible bacteria
• Urinary Tract Infection
• Ocular bacterial infections