Menthol

Generic Name: Menthol

Brand Names: Activon Arthritis, Bengay, Calazime Skin Protectant, Calmodrox, Calmoseptine Ointment, Capzasin Quick Relief, Chloraseptic Sore Throat, Chloraseptic Sore Throat + Cough, Delsym Cough Plus Soothing Action, Delsym Cough Relief Plus Soothing Action, Dendracin Neurodendraxcin, Fast Freeze, Flexall Ultra Plus, Gold Bond Maximum Relief, Icy Hot Arthritis, Ivy-dry Cream, Lidopro, Lidothol, Listerine Antiseptic, Max-freeze, Medi-derm, Medi-derm With Lidocaine, Medicaine Sting and Bite, Medrox, Men-phor, Mentholatum, Orasep Reformulated Dec 2013, Ortho-nesic, Rematex, Salonpas Gel-patch, Salonpas Pain Relieving Patch, Sarna Sensitive, Sucrets, Tiger Balm, Vaporex, Vicks Vaporub, Xoten-C

Drug Type: Small Molecule

Chemical Formula: C_₁₀H_₂₀O

CAS Number: 1490-04-6

Unique Ingredient Identifier: L7T10EIP3A

Overview

No overview information available.

Indication

No indication information available.

Associated Conditions

No associated conditions information available.

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Menthol Stimulation of Brown Adipose Tissue in Humans: Aim 1	2025/06/22	NCT07030725	Phase 1	Recruiting	Indiana University
TRPM8 in Acute Ischemic Stroke by Topical Menthol	2023/05/26	NCT05877079	Phase 2	Completed	Taipei Medical University Hospital
Topical CBD for Musculoskeletal Pain	2022/06/09	NCT05411913	Phase 3	UNKNOWN	Apothyx, Co.
The Influence of Menthol Gel During Exercise With Heat	2022/03/31	NCT05302804	Phase 4	Completed	University of Nebraska
A Study to Evaluate the Efficacy and Safety of K-285 Compared With Menthol Gel for the Treatment of Delayed Onset Muscle Soreness (DOMS) in the Lower Extremity	2020/07/23	NCT04484428	Phase 2	Terminated	Kowa Research Institute, Inc.
The Effects of Nasal Airflow on Upper Airway Dilator Muscles During Sleep	2018/04/24	NCT03506178	Not Applicable	UNKNOWN	Beijing Tongren Hospital
Effects of Flavors on Nicotine Reinforcement in Smokers	2017/08/09	NCT03243630	Early Phase 1	Completed	Yale University
Vascular Effects of a Single Bout of Electronic Cigarette Use	2017/07/06	NCT03209661	Phase 1	Completed	University of Texas at Austin
Menthol for PDT Pain Relief	2016/12/06	NCT02984072	Phase 4	Completed	University of Dundee
Topical Menthol +/- Mannitol for Painful Diabetic Peripheral Neuropathy	2016/04/05	NCT02728687	Phase 1	Completed	University of British Columbia

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
RAYO ACTIVE ICE	Quimicas Handal de Centroamerica SA de CV	83033-1598	TOPICAL	1 g in 1 g	1/10/2024
RockSauce Warming Massage	Nantong Health & Beyond Hygienic Products Inc.	43473-076	TOPICAL	100 mg in 1 mL	5/27/2025
Medrox-Rx	Pharmaceutica North America, Inc.	45861-005	TOPICAL	8.4 g in 120 g	10/27/2011
Major Arthritis Pain Relief Patch	Major Pharmaceuticals	0904-7342	TOPICAL	3 g in 100 g	8/12/2025
Lidothol Gel	Direct_Rx	72189-621	CUTANEOUS	5 g in 100 g	5/12/2025
Antispetic	Big Lots	50594-664	ORAL	0.42 mg in 1 mL	5/7/2025
SUGAR FREE LEMON MINT HERB THROAT DROPS	Ricola USA Inc.	63667-956	ORAL	1.1 mg in 1 1	4/22/2025
Xpect Stopain Clinical	Cintas Corporation	42961-257	TOPICAL	100 mg in 1 mL	5/21/2025
PR	Amphp, Inc	72358-101	TOPICAL	0.5 g in 100 g	3/3/2025
Silvera Pain Relief Patch	Home Aide Diagnostics, Inc.	69379-037	TOPICAL	5 g in 100 g	12/2/2014

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
No HSA approvals found for this drug.

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
BACAMINE LOTION	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	3/25/1982
AICADRYL LOTION	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	9/30/1981
FAIR-WAY GEL	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	1/30/1992
DIPHENMIN EXPECTORANT	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	4/27/1979
RADISOL ACID SALICYLIC APPLICATION	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	1/24/1979
CALABEN LOTION	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	6/24/1980
CALOX CREAM	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	2/22/1980
PANADOL PAIN RELIEF PATCH	N/A	Haleon Hong Kong Limited	N/A	N/A	11/3/2007
CURCYTOL SKIN LOTION (SPRAY)	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	2/11/1998
SALIRUB OINTMENT	N/A	MARCHING PHARMACEUTICAL LIMITED	N/A	N/A	3/11/2006

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
VICKS INHALER inhalation tube	10293	Procter & Gamble Australia Pty Ltd	Medicine	A	6/24/1991
GOLD CROSS MUSCLE RUB CREAM jar	13916	iNova Pharmaceuticals (Australia) Pty Ltd	Medicine	A	9/5/1991
KUGELMANS HERBAL HEAT LINIMENT bottle	45809	H.E Kugelman & Co	Medicine	A	7/21/1993
VICKS VAPORUB VAPORIZING OINTMENT jar	61019	Procter & Gamble Australia Pty Ltd	Medicine	A	1/21/2000
BIOFREEZE ROLL-ON GEL	315940	Ausmedic Australia Pty Ltd	Medicine	A	3/29/2019
Bio-Pain Rid for Tennis Elbow Cream	316271	Australia Biotechnology Group Pty Ltd	Medicine	A	4/8/2019
Ivycool Plus	422950	Stride Consultancy	Medicine	A	9/28/2023
Painaway Forte+ Heat Joint & Muscle Pain Relief Spray	387805	BSPSPA Pty Ltd	Medicine	A	5/3/2022
"Exelgel" Muscle and Joint Relieving Gel	384756	MedTAS Pty Ltd	Medicine	A	2/28/2022
Vicks VapoRub Lavender	454488	Procter & Gamble Australia Pty Ltd	Medicine	A	7/5/2024

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
RICOLA SWISS HERB COUGH DROPORANGE MINT	ricola ltd.	01943766	Lozenge - Oral	0.5 MG	12/31/1993
OBUS FORM THERAPEUTIC ICE GEL	the mentholatum company of canada ltd	02231220	Gel - Topical	3 %	4/2/1998
CELESTIAL SEASONINGS HERBAL THROAT DROPS - GOLDEN HERBAL BLEND	warner-lambert canada inc.	02232668	Lozenge - Oral	1.5 MG / LOZ	8/13/1998
HALLS MENTHO LYPTUS COUGH TAB BLACK CURRANT	adams canada, division of warner-lambert canada inc.	00627070	Lozenge - Oral	7.2 MG / LOZ	12/31/1984
HERBON COUGH DROPS GLACIAL MINT	herbon naturals inc.	02231756	Drops - Oral	8 MG / DROP	9/8/1997
GOLD BOND MEDICATED ANTI-ITCH CREAM	sanofi consumer health inc	02236991	Cream - Topical	1 % / W/W	1/11/1999
FLEX-ALL 454 16% GEL	chattem canada	02007258	Gel - Topical	16 %	12/31/1994
ARTIC ICE ANALGESIC GEL 2.5%	scott chemical canada	01915126	Gel - Topical	2.5 %	10/28/1998
BENTASIL HONEY-LEMON	carter-horner corp.	02230938	Lozenge - Oral	1.3 MG / LOZ	7/20/1998
BUCKLEY'S MUCUS & PHLEGM	haleon canada ulc	02346451	Syrup - Oral	10 MG / 5 ML	8/2/2010

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
No CIMA AEMPS (Spain) approvals found for this drug.

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

Related News

Menthol Cigarette Bans Drive Smokers Toward Cessation Therapies Rather Than Alternative Tobacco Products

4 months ago

Recent research shows menthol cigarette smokers prefer nicotine replacement therapies over traditional cigarettes when menthol products are unavailable, potentially improving public health outcomes.

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