Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954.
This drug originates from the foxglove plant, also known as the Digitalis plant, studied by William Withering, an English physician and botanist in the 1780s. Prior to this, a Welsh family, historically referred to as the Physicians of Myddvai, formulated drugs from this plant. They were one of the first to prescribe cardiac glycosides, according to ancient literature dating as early as the 1250s.
Digoxin is indicated in the following conditions: 1) For the treatment of mild to moderate heart failure in adult patients. 2) To increase myocardial contraction in children diagnosed with heart failure. 3) To maintain control ventricular rate in adult patients diagnosed with chronic atrial fibrillation.
In adults with heart failure, when it is clinically possible, digoxin should be administered in conjunction with a diuretic and an angiotensin-converting enzyme (ACE) inhibitor for optimum effects.
Quintiles, Overland Park, Kansas, United States
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Novartis Investigative Site, Manchester, United Kingdom
Emory University School of Medicine/Winship Cancer Institute Phase 1 Working Group, Atlanta, Georgia, United States
Fattouma Bourguiba University Hospital, Monastir, Tunisia
Sahloul University Hospital, Hammam sousse, Sousse, Tunisia
The first affiliate of Xi'an Jiaotong University, Xi'an, Shanxi, China
The First Affiliated Hospital of Xi'an Jiaotong University, Xian, Shaanxi, China
Parexel Early Phase Unit, Baltimor, Maryland, United States
Queen Elizabeth Hospital, Birmingham, West Midlands, United Kingdom
City Hospital, Birmingham, West Midlands, United Kingdom
1344.3.1 Boehringer Ingelheim Investigational Site, Biberach, Germany
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