Overview
evorpacept is under investigation in clinical trial NCT04755244 (A Study of Evorpacept (ALX148) With Venetoclax and Azacitidine for Acute Myeloid Leukemia (ASPEN-05)).
Indication
No indication information available.
Associated Conditions
No associated conditions information available.
Research Report
An Expert Monograph on Phenol (Carbolic Acid)
Executive Summary
Phenol (CAS: 108-95-2; DrugBank ID: DB03255), also known historically as carbolic acid, is an aromatic organic compound of profound significance in the annals of medicine and modern industry. This report provides a comprehensive, multi-disciplinary analysis of phenol, synthesizing data on its chemical properties, historical context, industrial production, pharmacology, clinical applications, toxicology, and global regulatory status. The central theme that emerges is the compound's pronounced duality: at low, controlled concentrations, it functions as a valuable antiseptic and local anesthetic, yet at higher concentrations, it is a potent, non-specific protoplasmic poison capable of causing severe corrosive injury and systemic toxicity.
Historically, phenol's application by Joseph Lister in the 1860s as an antiseptic agent revolutionized surgery, providing the first practical validation of germ theory and dramatically reducing post-operative mortality. This foundational role contrasts with its modern utility, which is confined to highly specialized and niche applications. Industrially, phenol is a critical chemical precursor, produced predominantly via the Cumene (Hock) process, a method that intrinsically links its supply and cost to the co-production of acetone, creating a notable economic interdependence with diverse industrial sectors.
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2025/06/06 | Phase 1 | Recruiting | |||
2023/05/22 | Phase 1 | Recruiting | |||
2023/03/28 | Phase 2 | Recruiting | |||
2022/09/01 | Phase 1 | Completed | |||
2022/07/20 | Phase 2 | Recruiting | Alexander B Olawaiye, MD | ||
2021/12/22 | Phase 2 | Active, not recruiting | |||
2021/08/30 | Phase 1 | Completed | |||
2021/08/12 | Phase 2 | Active, not recruiting | |||
2021/02/16 | Phase 1 | Terminated | |||
2020/12/19 | Phase 2 | Active, not recruiting |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||
Health Canada Drug Approvals
Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
|---|---|---|---|---|---|
| No Health Canada approvals found for this drug. | |||||
CIMA AEMPS Drug Approvals
Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
|---|---|---|---|---|---|
| No CIMA AEMPS (Spain) approvals found for this drug. | |||||
Philippines FDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
Approved Product | Company | Registration Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
Medicine Name | MA Holder | MA Number | Pharmaceutical Form | Active Ingredient | Authorization Date |
|---|---|---|---|---|---|
| No UK EMC drug information found for this drug. | |||||
Help Us Improve
Your feedback helps us provide better drug information and insights.