Vitamin D3

Generic Name
Vitamin D3
Brand Names
Adrovance, Animi-3 With Vitamin D, Citranatal B-calm Kit, Citranatal Harmony, Fosamax Plus D, Fosavance, Infuvite, Infuvite Pediatric, Mvc-fluoride, Natafort, Pregvit, Vidextra
Drug Type
Small Molecule
Chemical Formula
C27H44O
CAS Number
67-97-0
Unique Ingredient Identifier
1C6V77QF41
Background

Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight . Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-derived form, vitamin D2 (ergocalciferol), are considered the main forms of vitamin d and are found in various types of food for daily intake . Structurally, ergocalciferol differs from cholecalciferol in that it possesses a double bond between C22 and C23 and has an additional methyl group at C24 . Finally, ergocalciferol is pharmacologically less potent than cholecalciferol, which makes vitamin D3 the preferred agent for medical use .

Appropriate levels of vitamin D must be upheld in the body in order to maintain calcium and phosphorus levels in a healthy physiologic range to sustain a variety of metabolic functions, transcription regulation, and bone metabolism . However, studies are also ongoing to determine whether or not cholecalciferol may also play certain roles in cancer, autoimmune disorders, cardiovascular disease, and other medical conditions that may be associated with vitamin D deficiency .

Indication

Cholecalciferol use is indicated for the treatment of specific medical conditions like refractory rickets (or vitamin D resistant rickets), hypoparathyroidism, and familial hypophosphatemia .

Concurrently, as one of the most commonly utilized forms of vitamin D, cholecalciferol is also very frequently used as a supplement in individuals to maintain sufficient vitamin d levels in the body or to treat vitamin D deficiency, as well as various medical conditions that can be associated directly or indirectly with vitamin d insufficiency like osteoporosis and chronic kidney disease, among others .

Associated Conditions
Bone Fractures, Calcium and Vitamin D Deficiencies, Deficiency of Vitamin D3, Deficiency, Vitamin A, Deficiency, Vitamin D, Hip Fracture, Hypoparathyroidism, Hypophosphatemia, Familial, Menopause, Osteomalacia, Osteoporosis, Postmenopausal Osteoporosis, Vertebral Fractures, Vitamin D Resistant Rickets, Vitamin Deficiency, Severe Bone Resorption, Spine fracture
Associated Therapies
Calcium supplementation, Nutritional supplementation, Vitamin D Supplementation, Vitamin supplementation

Ivermectin-Azithromycin-Cholecalciferol (IvAzCol) Combination Therapy for COVID-19

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2020-05-22
Last Posted Date
2022-03-10
Lead Sponsor
Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Target Recruit Count
30
Registration Number
NCT04399746
Locations
🇲🇽

Outpatient treatment, Mexico City, Mexico

High vs Low Dose Vitamin D in Patients With Diabetic Peripheral Neuropathy

First Posted Date
2020-05-06
Last Posted Date
2020-05-06
Lead Sponsor
Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Target Recruit Count
68
Registration Number
NCT04377399
Locations
🇷🇺

Almazov National Medical Research Centre, Saint Petersburg, Russian Federation

Vitamin D as a Key Player in Rheumatoid Arthritis

First Posted Date
2020-04-14
Last Posted Date
2021-06-24
Lead Sponsor
Assiut University
Target Recruit Count
40
Registration Number
NCT04344405
Locations
🇪🇬

Manal Hassanien, Assiut, Assuit, Egypt

Can Vitamin D Reduce Heart Muscle Damage After Bypass Surgery?

First Posted Date
2020-03-27
Last Posted Date
2021-10-19
Lead Sponsor
Shahid Beheshti University of Medical Sciences
Target Recruit Count
70
Registration Number
NCT04323852
Locations
🇮🇷

modarres Hospital, Tehran, Iran, Islamic Republic of

Intralesional Vitamin D Injection for Treatment of Common Warts

Phase 2
Completed
Conditions
Interventions
First Posted Date
2020-02-20
Last Posted Date
2024-04-30
Lead Sponsor
Stephen P. Merry
Target Recruit Count
77
Registration Number
NCT04278573
Locations
🇺🇸

Mayo Clinic, Rochester, Minnesota, United States

Injections of Glutamic Acid Decarboxylase (GAD) for LADA Type of Diabetes

First Posted Date
2020-02-10
Last Posted Date
2022-05-26
Lead Sponsor
Norwegian University of Science and Technology
Target Recruit Count
14
Registration Number
NCT04262479
Locations
🇸🇪

Akademiskt Specialistcentrum, Centrum for Diabetes, and Karolinska Institute, Stockholm, Sweden

🇳🇴

Department of Endocrinology, St Olavs Hospital, Trondheim, Norway

Biological Effect of Vitamin D in Patients With Urothelial Carcinoma

Phase 4
Completed
Conditions
Interventions
First Posted Date
2019-12-12
Last Posted Date
2022-08-03
Lead Sponsor
Germans Trias i Pujol Hospital
Target Recruit Count
2
Registration Number
NCT04197089
Locations
🇪🇸

Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain

Personalized Treatment Algorithms for Difficult-to-treat Asthma

First Posted Date
2019-11-27
Last Posted Date
2021-08-20
Lead Sponsor
Children's Hospital Medical Center, Cincinnati
Target Recruit Count
21
Registration Number
NCT04179461
Locations
🇺🇸

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States

Evaluating Vitamin D3 Supplement on Post-Op Outcomes

Phase 4
Completed
Conditions
Interventions
First Posted Date
2019-11-26
Last Posted Date
2023-04-12
Lead Sponsor
Rush University Medical Center
Target Recruit Count
137
Registration Number
NCT04177758
Locations
🇺🇸

Rush University medical Center, Chicago, Illinois, United States

Protective Role of Vitamin D in Breast Cancer Patients Treated With Doxorubicin

Phase 2
Completed
Conditions
Interventions
First Posted Date
2019-11-18
Last Posted Date
2021-02-03
Lead Sponsor
Damanhour University
Target Recruit Count
100
Registration Number
NCT04166253
Locations
🇪🇬

Damnhour university, Beheira, Egypt

© Copyright 2024. All Rights Reserved by MedPath