Vitamin D3

Generic Name
Vitamin D3
Brand Names
Adrovance, Animi-3 With Vitamin D, Citranatal B-calm Kit, Citranatal Harmony, Fosamax Plus D, Fosavance, Infuvite, Infuvite Pediatric, Mvc-fluoride, Natafort, Pregvit, Vidextra
Drug Type
Small Molecule
Chemical Formula
C27H44O
CAS Number
67-97-0
Unique Ingredient Identifier
1C6V77QF41
Background

Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight . Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-derived form, vitamin D2 (ergocalciferol), are considered the main forms of vitamin d and are found in various types of food for daily intake . Structurally, ergocalciferol differs from cholecalciferol in that it possesses a double bond between C22 and C23 and has an additional methyl group at C24 . Finally, ergocalciferol is pharmacologically less potent than cholecalciferol, which makes vitamin D3 the preferred agent for medical use .

Appropriate levels of vitamin D must be upheld in the body in order to maintain calcium and phosphorus levels in a healthy physiologic range to sustain a variety of metabolic functions, transcription regulation, and bone metabolism . However, studies are also ongoing to determine whether or not cholecalciferol may also play certain roles in cancer, autoimmune disorders, cardiovascular disease, and other medical conditions that may be associated with vitamin D deficiency .

Indication

Cholecalciferol use is indicated for the treatment of specific medical conditions like refractory rickets (or vitamin D resistant rickets), hypoparathyroidism, and familial hypophosphatemia .

Concurrently, as one of the most commonly utilized forms of vitamin D, cholecalciferol is also very frequently used as a supplement in individuals to maintain sufficient vitamin d levels in the body or to treat vitamin D deficiency, as well as various medical conditions that can be associated directly or indirectly with vitamin d insufficiency like osteoporosis and chronic kidney disease, among others .

Associated Conditions
Bone Fractures, Calcium and Vitamin D Deficiencies, Deficiency of Vitamin D3, Deficiency, Vitamin A, Deficiency, Vitamin D, Hip Fracture, Hypoparathyroidism, Hypophosphatemia, Familial, Menopause, Osteomalacia, Osteoporosis, Postmenopausal Osteoporosis, Vertebral Fractures, Vitamin D Resistant Rickets, Vitamin Deficiency, Severe Bone Resorption, Spine fracture
Associated Therapies
Calcium supplementation, Nutritional supplementation, Vitamin D Supplementation, Vitamin supplementation

Vitamin D and Polycystic Ovarian Syndrome (PCOS)

First Posted Date
2019-06-18
Last Posted Date
2023-05-12
Lead Sponsor
Aga Khan University
Target Recruit Count
300
Registration Number
NCT03989778
Locations
🇵🇰

Dr Rehana Rehman, Karachi, Sindh, Pakistan

Vitamin D3 For CGD Patients With BCGosis/Itis

First Posted Date
2019-06-13
Last Posted Date
2024-07-09
Lead Sponsor
Children's Hospital of Fudan University
Target Recruit Count
50
Registration Number
NCT03984890
Locations
🇨🇳

Children's Hospital of Fudan University, Shanghai, Shanghai, China

Vitamin D 24'000 IU for Oral Intermittent Supplementation

First Posted Date
2019-04-18
Last Posted Date
2020-06-04
Lead Sponsor
University Hospital, Basel, Switzerland
Target Recruit Count
58
Registration Number
NCT03920150
Locations
🇨🇭

Pharmaceutical Care Research Group, Basel, Switzerland

Studying the Effect of Methotrexate Alone Versus Methotrexate and Vitamin D on the Cardiovascular Risk of Psoriatic Patients

Phase 4
Conditions
Interventions
First Posted Date
2019-04-05
Last Posted Date
2019-04-05
Lead Sponsor
Cairo University
Target Recruit Count
30
Registration Number
NCT03904680

Vitamin D Supplementation in PCOS Patients

Phase 4
Completed
Conditions
Interventions
First Posted Date
2019-04-02
Last Posted Date
2022-05-05
Lead Sponsor
Tanta University
Target Recruit Count
170
Registration Number
NCT03898934
Locations
🇪🇬

Ayman Shehata Dawood, Tanta, Algharbia, Egypt

The Effect Of Vitamin D Replacement Therapy On Serum Leptin And Follicular Growth Pattern In Women With Resistant Polycystic Ovary

First Posted Date
2019-01-16
Last Posted Date
2019-01-16
Lead Sponsor
Cairo University
Target Recruit Count
100
Registration Number
NCT03806036
Locations
🇪🇬

Kasr Alainy medical school, Cairo, Egypt

Vitamin D Supplementation for Acute Bronchiolitis

Phase 2
Completed
Conditions
Interventions
First Posted Date
2019-01-10
Last Posted Date
2019-01-11
Lead Sponsor
Mansoura University
Target Recruit Count
60
Registration Number
NCT03799406
Locations
🇪🇬

Mansoura University Children's Hospital, Mansourah, Egypt

Different Doses of Vitamin D and T Regulatory Cells in Preterm Infants

Phase 1
Completed
Conditions
Interventions
First Posted Date
2019-01-04
Last Posted Date
2019-01-07
Lead Sponsor
Cairo University
Target Recruit Count
40
Registration Number
NCT03793309

Effect of Vitamin D3 on Lung Function and Exercise Tolerance in COPD Patients

Phase 1
Completed
Conditions
Interventions
First Posted Date
2018-12-20
Last Posted Date
2019-01-10
Lead Sponsor
Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Target Recruit Count
48
Registration Number
NCT03781895
Locations
🇧🇩

Samia Hassan, Dhaka, Bangladesh

© Copyright 2024. All Rights Reserved by MedPath