Vitamin D3

Generic Name
Vitamin D3
Brand Names
Adrovance, Animi-3 With Vitamin D, Citranatal B-calm Kit, Citranatal Harmony, Fosamax Plus D, Fosavance, Infuvite, Infuvite Pediatric, Mvc-fluoride, Natafort, Pregvit, Vidextra
Drug Type
Small Molecule
Chemical Formula
C27H44O
CAS Number
67-97-0
Unique Ingredient Identifier
1C6V77QF41
Background

Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight . Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-derived form, vitamin D2 (ergocalciferol), are considered the main forms of vitamin d and are found in various types of food for daily intake . Structurally, ergocalciferol differs from cholecalciferol in that it possesses a double bond between C22 and C23 and has an additional methyl group at C24 . Finally, ergocalciferol is pharmacologically less potent than cholecalciferol, which makes vitamin D3 the preferred agent for medical use .

Appropriate levels of vitamin D must be upheld in the body in order to maintain calcium and phosphorus levels in a healthy physiologic range to sustain a variety of metabolic functions, transcription regulation, and bone metabolism . However, studies are also ongoing to determine whether or not cholecalciferol may also play certain roles in cancer, autoimmune disorders, cardiovascular disease, and other medical conditions that may be associated with vitamin D deficiency .

Indication

Cholecalciferol use is indicated for the treatment of specific medical conditions like refractory rickets (or vitamin D resistant rickets), hypoparathyroidism, and familial hypophosphatemia .

Concurrently, as one of the most commonly utilized forms of vitamin D, cholecalciferol is also very frequently used as a supplement in individuals to maintain sufficient vitamin d levels in the body or to treat vitamin D deficiency, as well as various medical conditions that can be associated directly or indirectly with vitamin d insufficiency like osteoporosis and chronic kidney disease, among others .

Associated Conditions
Bone Fractures, Calcium and Vitamin D Deficiencies, Deficiency of Vitamin D3, Deficiency, Vitamin A, Deficiency, Vitamin D, Hip Fracture, Hypoparathyroidism, Hypophosphatemia, Familial, Menopause, Osteomalacia, Osteoporosis, Postmenopausal Osteoporosis, Vertebral Fractures, Vitamin D Resistant Rickets, Vitamin Deficiency, Severe Bone Resorption, Spine fracture
Associated Therapies
Calcium supplementation, Nutritional supplementation, Vitamin D Supplementation, Vitamin supplementation

Effect of Vitamin D Replacement on Bone Healing in Mini-dental Implants

First Posted Date
2017-11-29
Last Posted Date
2017-11-29
Lead Sponsor
Universidade de Passo Fundo
Target Recruit Count
20
Registration Number
NCT03356730
Locations
🇧🇷

Isadora Rinaldi, Rondinha, Rio Grande Do Sul, Brazil

Impact of Correction of Vitamin D Deficiency in Oxidative Stress in Patients With Prediabetes (VICOX)

First Posted Date
2017-11-29
Last Posted Date
2023-03-15
Lead Sponsor
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Target Recruit Count
31
Registration Number
NCT03356873
Locations
🇲🇽

Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico

Efficacy and Safety of High Dose Vitamin D Supplementation in Patients Undergoing HSCT

Phase 2
Conditions
Interventions
First Posted Date
2017-10-25
Last Posted Date
2017-10-25
Lead Sponsor
Seoul National University Hospital
Target Recruit Count
88
Registration Number
NCT03320915
Locations
🇰🇷

Seoul National University Hospital, Seoul, Korea, Republic of

High-Dose Vitamin D Induction in Optic Neuritis

First Posted Date
2017-10-05
Last Posted Date
2024-07-24
Lead Sponsor
University of Calgary
Target Recruit Count
12
Registration Number
NCT03302585
Locations
🇨🇦

Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada

Influence of Vitamin D Supplementation on Serum BDNF Level and Cognitive Function in Schizophrenia

First Posted Date
2017-09-15
Last Posted Date
2020-04-02
Lead Sponsor
Universitas Padjadjaran
Target Recruit Count
40
Registration Number
NCT03284294

Importance of Dosing Regimen for the Effect of Vitamin D Supplementation

Phase 3
Completed
Conditions
Interventions
First Posted Date
2017-09-05
Last Posted Date
2018-05-24
Lead Sponsor
University of Tromso
Target Recruit Count
61
Registration Number
NCT03272126
Locations
🇳🇴

University Hospital of North Norway, Tromsø, Norway

Therapeutic Benefit of Preoperative Supplemental Vitamin D in Patients Undergoing Brain Tumor Surgery

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2017-08-14
Last Posted Date
2018-07-31
Lead Sponsor
Shahid Beheshti University
Target Recruit Count
60
Registration Number
NCT03248544
Locations
🇮🇷

Shohada Tajrish Hospital, Tehran, Iran, Islamic Republic of

🇮🇷

Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of

HDDO-1614 Intervention Trial

First Posted Date
2017-07-31
Last Posted Date
2017-12-11
Lead Sponsor
Hyundai Pharmaceutical Co., LTD.
Target Recruit Count
37
Registration Number
NCT03234244
Locations
🇰🇷

Inha University Hospital, Junggu, Incheon, Korea, Republic of

Vitamin D Supplementation in Vitamin Deficient Women Undergoing IVF Cycles: Does it Affect the Fertility Outcome?

Phase 4
Completed
Conditions
Interventions
First Posted Date
2017-07-06
Last Posted Date
2021-10-06
Lead Sponsor
Cairo University
Target Recruit Count
200
Registration Number
NCT03209856
Locations
🇪🇬

Department of Obstetrics and Gynecology, Kasr Al-Ainy hospital, Cairo, Greater Cairo, Egypt

Study of Pembrolizumab, Radiation and Immune Modulatory Cocktail in Cervical/Uterine Cancer

First Posted Date
2017-06-19
Last Posted Date
2021-09-08
Lead Sponsor
University Hospital, Ghent
Target Recruit Count
43
Registration Number
NCT03192059
Locations
🇧🇪

Institut Jules Bordet, Brussels, Belgium

🇧🇪

University Hospital Antwerp, Antwerp, Belgium

🇧🇪

University Hospital Gent, Gent, Belgium

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