Finasteride

Generic Name: Finasteride

Brand Names: Entadfi, Propecia, Proscar

Drug Type: Small Molecule

Chemical Formula: C_₂₃H_₃₆N_₂O_₂

CAS Number: 98319-26-7

Unique Ingredient Identifier: 57GNO57U7G

Background: Finasteride is a synthetic 4-azasteroid compound and specific inhibitor of steroid Type II 5α-reductase, which is an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). It works in a similar fashion as dutasteride, which is another 5-alpha-reductase inhibitor, by exerting antiandrogenic effects. Finasteride is an ...

Indication: Finasteride is indicated for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate to improve symptoms, reduce the risk of acute urinary retention, and reduce the risk of the need for surgery including transurethral resection of the prostate (TURP) and prostatectomy. A combination product with tadalafil is also used...

Associated Conditions: Androgenetic Alopecia (AGA), Benign Prostatic Hyperplasia (BPH), Idiopathic Hirsutism, Symptomatic benign prostatic hyperplasia (BPH)

Associated Therapies: -

Clinical Trials

EMA reviews hair loss products following concerns about suicidal thoughts

The European Medicines Agency is reviewing finasteride and dutasteride, used for hair loss and enlarged prostate, due to concerns about suicidal thoughts. The French medicines agency requested the review, noting a 'reasonable possibility' of a link, despite no established connection. Organon, maker of Propecia and Proscar, supports the review process, while GSK's Avodart is also under scrutiny. The EMA will recommend whether these medicines' marketing authorizations should remain, change, or be withdrawn.

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