Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleeding following tooth extraction.
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Evolution of Thromboelastography During Tranexamic Acid Treatment
- Conditions
- Interventions
- First Posted Date
- 2019-01-11
- Last Posted Date
- 2023-05-06
- Target Recruit Count
- 18
- Registration Number
- NCT03801122
- Locations
- 🇫🇷
CHU de Saint-Etienne, Saint-Étienne, France
The Immunomodulatory Effect of Antrifibrinolytic (Tranexamic Acid) in Total Knee Arthroplasty
- First Posted Date
- 2019-01-08
- Last Posted Date
- 2019-01-08
- Lead Sponsor
- Sisters of Mercy University Hospital
- Target Recruit Count
- 80
- Registration Number
- NCT03795649
- Locations
- 🇭🇷
Klinički Bolnički Centar Sestre Milosrdnice, Zagreb, Croatia
Transfusion of Red Blood Cells, Tranexamic Acid and Fibrinogen Concentrate for Severe Trauma Hemorrhage at Pre-hospital Phase of Care.
- Conditions
- Interventions
- First Posted Date
- 2018-12-19
- Last Posted Date
- 2024-01-25
- Lead Sponsor
- Banc de Sang i Teixits
- Target Recruit Count
- 79
- Registration Number
- NCT03780894
- Locations
- 🇪🇸
Hospital Josep Trueta, Girona, Spain
Sublingual Misoprostol With or Without Intravenous Tranexamic Acid During Hemorrhagic Cesarean Section
- Conditions
- Interventions
- First Posted Date
- 2018-12-13
- Last Posted Date
- 2019-02-18
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 150
- Registration Number
- NCT03774706
- Locations
- 🇪🇬
Aswan University, Aswan, Egypt
Tranexamic Acid vs Fractional CO2 Laser in Post-acne Hyperpigmentation
- Conditions
- Interventions
- First Posted Date
- 2018-12-05
- Last Posted Date
- 2018-12-05
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 25
- Registration Number
- NCT03765021
The Effect of Tranexamic Acid. A Randomised Study of Patients Undergoing Elective Lumbar Spine Surgery.
- Conditions
- Interventions
- First Posted Date
- 2018-10-22
- Last Posted Date
- 2018-10-22
- Lead Sponsor
- Karen Hoejmark Hansen
- Target Recruit Count
- 250
- Registration Number
- NCT03714360
- Locations
- 🇩🇰
Spine Center of Southern Denmark, Middelfart, Denmark
Carbetocin Versus Buccal Misoprostol Plus IV Tranexamic Acid for Prevention of Postpartum Hemorrhage at Cesarean Section
- Conditions
- Interventions
- First Posted Date
- 2018-10-18
- Last Posted Date
- 2020-08-05
- Lead Sponsor
- Aswan University Hospital
- Target Recruit Count
- 400
- Registration Number
- NCT03710317
- Locations
- 🇪🇬
Aswan University, Aswan, Egypt
Protective Effect of Tranexamic Acid on Shedding of the Endothelial Glycocalyx in Patients Undergoing Spinal Fusion Surgery
- Conditions
- Interventions
- First Posted Date
- 2018-10-05
- Last Posted Date
- 2020-10-19
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 128
- Registration Number
- NCT03697681
- Locations
- 🇰🇷
Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea, Republic of
Oral Tranexamic Acid and Laser for Treatment of Melasma
- Conditions
- First Posted Date
- 2018-09-27
- Last Posted Date
- 2018-09-27
- Lead Sponsor
- Laser and Skin Surgery Center of New York
- Target Recruit Count
- 32
- Registration Number
- NCT03686787
- Locations
- 🇺🇸
Laser & Skin Surgery Center of New York, New York, New York, United States
🇺🇸Dermatology & Laser Surgery Center, Houston, Texas, United States
Tranexamic Acid Per Inhalation for Treatment of Pulmonary Hemorrhage in Pediatric Patients
- Conditions
- Interventions
- First Posted Date
- 2018-09-18
- Last Posted Date
- 2020-08-03
- Lead Sponsor
- Baylor College of Medicine
- Target Recruit Count
- 20
- Registration Number
- NCT03676023
- Locations
- 🇺🇸
Texas Children's Hospital, Houston, Texas, United States
Drug Development Updates
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