Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleed...
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
TRanEXamic Acid to Decrease Heavy Menstrual Bleeding in Individuals Anticoagulated for Venous Thromboembolism Pilot Study
- Conditions
- Interventions
- First Posted Date
- 2024-06-11
- Last Posted Date
- 2024-06-12
- Lead Sponsor
- University Health Network, Toronto
- Target Recruit Count
- 20
- Registration Number
- NCT06452342
Evaluations of the Effects of Tranexamic Acid and Chlorhexidine Gel on Alveolar Osteitis Incidence
- Conditions
- Interventions
- First Posted Date
- 2024-05-30
- Last Posted Date
- 2024-05-30
- Lead Sponsor
- Recep Tayyip Erdogan University
- Target Recruit Count
- 98
- Registration Number
- NCT06435832
- Locations
- 🇹🇷
Recep Tayyip Erdoğan University, Rize, Turkey
Effect of Topical Tranexamic Acid on Postoperative Drainage in Minimally Invasive Transforaminal Lumbar Interbody Fusion (MI-TLIF)
- Conditions
- Interventions
- First Posted Date
- 2024-05-24
- Last Posted Date
- 2024-05-24
- Lead Sponsor
- Thanawan Longsuwan
- Target Recruit Count
- 28
- Registration Number
- NCT06427850
Role of TXA in Patients Undergoing Breast Free Flap Reconstruction
- Conditions
- Interventions
- First Posted Date
- 2024-05-24
- Last Posted Date
- 2024-06-05
- Lead Sponsor
- University of Virginia
- Target Recruit Count
- 100
- Registration Number
- NCT06428682
- Locations
- 🇺🇸
University of Virginia Medical Center, Charlottesville, Virginia, United States
Protest Trial: TXA vs Saline
- Conditions
- Interventions
- First Posted Date
- 2024-05-20
- Last Posted Date
- 2024-05-20
- Lead Sponsor
- Spectrum Health Hospitals
- Target Recruit Count
- 94
- Registration Number
- NCT06422273
- Locations
- 🇺🇸
Spectrum Health Hospitals, Grand Rapids, Michigan, United States
Tranexamic Acid in Vaginal Reconstructive Surgery
- Conditions
- Interventions
- First Posted Date
- 2024-05-17
- Last Posted Date
- 2024-05-17
- Target Recruit Count
- 36
- Registration Number
- NCT06419075
- Locations
- 🇺🇸
University of Texas Medical Branch Galveston, Galveston, Texas, United States
Tranexamic Acid for Reduction of Transfusion in Abdominal Surgery
- Conditions
- Interventions
- First Posted Date
- 2024-05-14
- Last Posted Date
- 2024-10-15
- Lead Sponsor
- Ulrich Ronellenfitsch, MD
- Target Recruit Count
- 850
- Registration Number
- NCT06414031
- Locations
- 🇩🇪
University Hospital Carl Gustav Carus Dresden, Dresden, Saxony, Germany
🇩🇪University Hospital, Dpt. of Abdominal, Vascular and Endocrine Surgery, Halle (Saale), Germany
Burn Study- Tranexamic Acid Versus Thrombin in Split Thickness Skin Graft
- Conditions
- Interventions
- First Posted Date
- 2024-04-23
- Last Posted Date
- 2024-10-07
- Lead Sponsor
- University of Kansas Medical Center
- Target Recruit Count
- 62
- Registration Number
- NCT06379724
- Locations
- 🇺🇸
The University of Kansas Health System, Kansas City, Kansas, United States
Vasopressin Versus Tranexamic Acid for Control of Blood Loss Related to Abdominal Hysterectomy
- Conditions
- Interventions
- First Posted Date
- 2024-03-04
- Last Posted Date
- 2024-03-06
- Lead Sponsor
- Al-Azhar University
- Target Recruit Count
- 387
- Registration Number
- NCT06290596
Prophylactic Endobronchial Tranexamic Acid to Reduce Bleeding in Transbronchial Cryobiopsy
- Conditions
- Interventions
- First Posted Date
- 2024-02-20
- Last Posted Date
- 2024-08-21
- Lead Sponsor
- Youssef Yammine
- Target Recruit Count
- 100
- Registration Number
- NCT06266546
- Locations
- 🇺🇸
Ascension Via Christi, Wichita, Kansas, United States
Drug Development Updates
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