Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleeding following tooth extraction.
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Safety of Topical Tranexamic Acid in Total Joint Arthroplasty in High Risk Patients
- Conditions
- Interventions
- First Posted Date
- 2015-12-31
- Last Posted Date
- 2018-05-31
- Lead Sponsor
- Albert Einstein College of Medicine
- Registration Number
- NCT02644473
The Effect of Topical Tranexamic Acid on Bleeding and Seroma Formation in After Undergoing Mastectomy
- Conditions
- Interventions
- First Posted Date
- 2015-12-11
- Last Posted Date
- 2020-05-12
- Lead Sponsor
- St. Olavs Hospital
- Target Recruit Count
- 202
- Registration Number
- NCT02627560
- Locations
- 🇳🇴
Department of Surgery, Aalesund Hospital, Ålesund, Norway
🇳🇴St Olavs University Hospital, Trondheim, Norway
Tranexamic Acid for Acute ICH Growth prEdicted by Spot Sign
- First Posted Date
- 2015-12-09
- Last Posted Date
- 2016-09-14
- Target Recruit Count
- 240
- Registration Number
- NCT02625948
- Locations
- 🇨🇳
Beijing Friendship Hospital, Beijing, Beijing, China
🇨🇳Beijing Haidian hospital, Beijing, Beijing, China
🇨🇳Beijing Huairou District Hospital, Beijing, Beijing, China
Use of Intravenous Tranexamic Acid During Myomectomy
- Conditions
- Interventions
- First Posted Date
- 2015-12-03
- Last Posted Date
- 2022-10-13
- Lead Sponsor
- George Washington University
- Target Recruit Count
- 60
- Registration Number
- NCT02620748
- Locations
- 🇺🇸
Medical Faculty Associates, Washington, District of Columbia, United States
A Study on the Safety of Tranexamic Acid for the Chronic Subdural Hematoma Population
- First Posted Date
- 2015-12-01
- Last Posted Date
- 2021-11-11
- Target Recruit Count
- 32
- Registration Number
- NCT02618382
- Locations
- 🇺🇸
Barrow Brain and Spine, Phoenix, Arizona, United States
Oral Tranexamic Acid Versus Diosmin for Treatment of Menorrhagia in Women Using Copper IUD
- First Posted Date
- 2015-11-30
- Last Posted Date
- 2015-11-30
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 100
- Registration Number
- NCT02616731
- Locations
- 🇪🇬
Ahmed Alanwar, Cairo, Egypt
Tranexamic Acid for Bleeding in Breast Surgery
- First Posted Date
- 2015-11-26
- Last Posted Date
- 2016-01-12
- Lead Sponsor
- Ottawa Hospital Research Institute
- Target Recruit Count
- 800
- Registration Number
- NCT02615366
Minimize Menorrhagia in Women With Von Willebrand Disease
- Conditions
- Interventions
- First Posted Date
- 2015-11-17
- Last Posted Date
- 2024-07-01
- Lead Sponsor
- Margaret Ragni
- Target Recruit Count
- 39
- Registration Number
- NCT02606045
- Locations
- 🇺🇸
Banner MD Anderson Cancer Center, Gilbert, Arizona, United States
🇺🇸Ohio State University Wexner Medical Center, Columbus, Ohio, United States
🇺🇸University of Pittsburgh and Hemophilia Center Western PA, Pittsburgh, Pennsylvania, United States
Tranexamic Acid Dosing for Total Joint Arthroplasty
- First Posted Date
- 2015-10-23
- Last Posted Date
- 2020-10-30
- Lead Sponsor
- Columbia University
- Target Recruit Count
- 84
- Registration Number
- NCT02584725
Tranexamic Acid in Intertrochanteric and Subtrochanteric Femur Fractures
- First Posted Date
- 2015-10-20
- Last Posted Date
- 2015-10-29
- Lead Sponsor
- Good Samaritan Regional Medical Center, Oregon
- Target Recruit Count
- 100
- Registration Number
- NCT02580227
- Locations
- 🇺🇸
Good Samaritan Hospital Corvallis, Corvallis, Oregon, United States
Drug Development Updates
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