Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleed...
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Tranexamic Acid Use on Pain, Mobility and Bleeding Following Total Hip and Total Knee Arthroplasty
- First Posted Date
- 2024-01-17
- Last Posted Date
- 2024-11-26
- Lead Sponsor
- St. Mary's Research Center, Canada
- Target Recruit Count
- 210
- Registration Number
- NCT06208267
Efficacy of Topical Versus Intravenous Tranexamic Acid in Controlling Blood Loss
- Conditions
- Interventions
- First Posted Date
- 2024-01-03
- Last Posted Date
- 2024-01-03
- Lead Sponsor
- Kasr El Aini Hospital
- Target Recruit Count
- 45
- Registration Number
- NCT06188052
- Locations
- 🇪🇬
Cairo University hospitals, Cairo, Egypt
Tranexamic Acid Dosage for Topical Treatment of Anterior Epistaxis
- Conditions
- Interventions
- First Posted Date
- 2023-12-28
- Last Posted Date
- 2023-12-28
- Lead Sponsor
- Izmir Ataturk Training and Research Hospital
- Target Recruit Count
- 152
- Registration Number
- NCT06183918
- Locations
- 🇹🇷
Ataturk 'Training and Research Hospital, Izmir, Basın Sitesi, Turkey
Prophylactic Tranexamic Acid Versus Adrenaline During Flexible Bronchoscopy
- Conditions
- Interventions
- First Posted Date
- 2023-11-24
- Last Posted Date
- 2023-12-26
- Lead Sponsor
- Clinical Hospital Centre Zagreb
- Target Recruit Count
- 840
- Registration Number
- NCT06145191
- Locations
- 🇭🇷
University Hospital Centre Zagreb, Zagreb, Croatia
Effect of TXA Oral Sol 5% in Patients Treated With DOACs or VKA and Undergoing a Single or Multiple Tooth Extraction
- Conditions
- Interventions
- First Posted Date
- 2023-11-22
- Last Posted Date
- 2024-08-01
- Lead Sponsor
- Hyloris Developments
- Target Recruit Count
- 280
- Registration Number
- NCT06143787
- Locations
- 🇭🇺
Arc-, Állcsont-, Szájsebészeti Osztály, Veszprém, Hungary
🇭🇷Dental Clinic Zagreb, Zagreb, Croatia
🇷🇴SCJU Craiova, Craiova, Romania
The Effect of ACT and Tranexamic Acid on Bleeding in Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2023-10-31
- Last Posted Date
- 2024-02-21
- Lead Sponsor
- Taichung Veterans General Hospital
- Target Recruit Count
- 150
- Registration Number
- NCT06109155
- Locations
- 🇨🇳
Taichung Veterans General Hospital, Taichung, Taiwan
🇨🇳Taichung Veterans General hospital, Taichung, Taiwan
Tranexamic Acid in Pediatric Scoliosis Surgery
- Conditions
- Interventions
- First Posted Date
- 2023-10-19
- Last Posted Date
- 2023-10-19
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 84
- Registration Number
- NCT06091891
- Locations
- 🇰🇷
Seoul national university hospital, Seoul, Korea, Republic of
Tranexamic Acid in Abdominoplasty.
- Conditions
- Interventions
- First Posted Date
- 2023-10-17
- Last Posted Date
- 2024-01-23
- Lead Sponsor
- Poznan University of Medical Sciences
- Target Recruit Count
- 60
- Registration Number
- NCT06086444
- Locations
- 🇵🇱
Poznan University of Medical Sciences, Poznan, Poznań, Poland
Comparing Tranexamic Acid Versus Ecbolics in Preventing Hemorrhage During and After Cesarean Section
- Conditions
- Interventions
- First Posted Date
- 2023-09-29
- Last Posted Date
- 2024-07-23
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 440
- Registration Number
- NCT06060327
- Locations
- 🇪🇬
Faculty of medicine - Cairo university, Cairo, Egypt
🇪🇬kasr elainy hospital (Faculty of Medicine - Cairo University), Cairo, Egypt
Postpartum Hemorrhage Reduction With Oral Tranexamic Acid: a Clinical Trial
- First Posted Date
- 2023-09-06
- Last Posted Date
- 2023-10-12
- Lead Sponsor
- Karolinska Institutet
- Target Recruit Count
- 1000
- Registration Number
- NCT06025916
- Locations
- 🇸🇪
Södersjukhuset (South General Hospital), Stockholm, Sweden
Drug Development Updates
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