Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleed...
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Single Dose Enteral Tranexamic Acid in Critically Ill Patients
- Conditions
- Interventions
- First Posted Date
- 2012-09-12
- Last Posted Date
- 2015-11-17
- Lead Sponsor
- San Diego Veterans Healthcare System
- Target Recruit Count
- 4
- Registration Number
- NCT01683747
- Locations
- 🇺🇸
VA San Diego Health Care System, San Diego, California, United States
Topical Tranexamic Acid and Acute Blood Loss in Total Hip Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2012-09-12
- Last Posted Date
- 2023-04-03
- Lead Sponsor
- Henry Ford Health System
- Target Recruit Count
- 139
- Registration Number
- NCT01683955
- Locations
- 🇺🇸
Henry Ford Hospital, Detroit, Michigan, United States
🇺🇸HFH Main campus, Detroit, Michigan, United States
Estradiol vs Lysteda in Treatment of Heavy Menstrual Bleeding
- Conditions
- Interventions
- First Posted Date
- 2012-08-07
- Last Posted Date
- 2015-02-16
- Lead Sponsor
- Kay I Waud MD PhD
- Target Recruit Count
- 100
- Registration Number
- NCT01659008
- Locations
- 🇺🇸
Sentara Norfolk General Emergency Department, Norfolk, Virginia, United States
🇺🇸Jones Institue Clinical Research Center, Norfolk, Virginia, United States
Haemorrhage Alleviation With Tranexamic Acid- Intestinal System
- First Posted Date
- 2012-08-06
- Last Posted Date
- 2020-04-17
- Lead Sponsor
- London School of Hygiene and Tropical Medicine
- Target Recruit Count
- 12009
- Registration Number
- NCT01658124
- Locations
- 🇬🇧
Over 50 countries Worldwide, London, United Kingdom
Study of Tranexamic Acid for Reducing Blood Requirement in Patients Undergoing Major Gastro-intestinal Surgery
- Conditions
- Interventions
- First Posted Date
- 2012-08-02
- Last Posted Date
- 2012-10-16
- Target Recruit Count
- 118
- Registration Number
- NCT01655641
- Locations
- 🇳🇵
Tribhuvan University Teaching Hospital, Kathmandu, Kathmandy, Nepal
Efficacy of Tranexamic Acid in Brain Tumor Resections
- Conditions
- Interventions
- First Posted Date
- 2012-08-02
- Last Posted Date
- 2012-08-02
- Target Recruit Count
- 100
- Registration Number
- NCT01655927
- Locations
- 🇨🇴
Colombian foundation center for epilepsy and neurological disease, Cartagena, Bolivar, Colombia
Tranexamic Acid Versus Placebo for Blood to Reduce Perioperative Bleeding Post-liver Resection
- Conditions
- Interventions
- First Posted Date
- 2012-07-26
- Last Posted Date
- 2015-09-18
- Lead Sponsor
- Sunnybrook Health Sciences Centre
- Target Recruit Count
- 24
- Registration Number
- NCT01651182
- Locations
- 🇨🇦
Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
Reduction Bleeding in Laminectomy With Double Doses of Tranexamic Acid
- First Posted Date
- 2012-07-18
- Last Posted Date
- 2013-12-18
- Lead Sponsor
- Mahidol University
- Target Recruit Count
- 78
- Registration Number
- NCT01643135
- Locations
- 🇹🇭
Manee Raksakietisak, Bangkok, Thailand
The Effect of Topical Application of Tranexamic Acid in Total Hip Arthroplasty Through the Direct Anterior Approach
- Conditions
- Interventions
- First Posted Date
- 2012-06-19
- Last Posted Date
- 2020-11-05
- Lead Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Target Recruit Count
- 80
- Registration Number
- NCT01622946
- Locations
- 🇧🇪
UZ Pellenberg, Pellenberg, Belgium
Reducing Post Operative Bleeding Following Cabg
- First Posted Date
- 2012-05-17
- Last Posted Date
- 2012-05-18
- Lead Sponsor
- University of Malaya
- Target Recruit Count
- 40
- Registration Number
- NCT01600599
- Locations
- 🇲🇾
Pusat Perubatan University Malaya, Petaling Jaya, Selangor, Malaysia
Drug Development Updates
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