Overview
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent. It was first patented in 1957 and received its initial US approval in 1986.
Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent. It was first patented in 1957 and received its initial US approval in 1986.
Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleeding following tooth extraction.
Associated Conditions
- Bleeding
- Heavy Menstrual Bleeding
- Hereditary Angioedema (HAE)
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2015/12/03 | Phase 1 | Completed | |||
2015/12/01 | Phase 4 | Completed | St. Joseph's Hospital and Medical Center, Phoenix | ||
2015/11/30 | Phase 1 | UNKNOWN | |||
2015/11/26 | Phase 4 | UNKNOWN | |||
2015/11/17 | Phase 3 | Terminated | Margaret Ragni | ||
2015/10/23 | Phase 4 | Completed | |||
2015/10/20 | Phase 4 | UNKNOWN | Good Samaritan Regional Medical Center, Oregon | ||
2015/10/19 | Phase 3 | Completed | |||
2015/10/07 | Not Applicable | Completed | |||
2015/10/05 | Phase 2 | Recruiting | Centre de recherche du Centre hospitalier universitaire de Sherbrooke |
FDA Drug Approvals
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Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
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|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
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| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
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PPB Drug Approvals
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| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
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| No TGA approvals found for this drug. | |||||