Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleed...
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Clinical Randomisation of an Antifibrinolytic in Significant Head Injury
- First Posted Date
- 2011-07-26
- Last Posted Date
- 2020-02-17
- Lead Sponsor
- London School of Hygiene and Tropical Medicine
- Target Recruit Count
- 12737
- Registration Number
- NCT01402882
- Locations
- 🇬🇪
High Technology Medical Center, University Clinic, Tbilisi, Georgia
Topical Tranexamic Acid and Acute Blood Loss in Total Knee Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2011-06-10
- Last Posted Date
- 2023-04-25
- Lead Sponsor
- Henry Ford Health System
- Target Recruit Count
- 101
- Registration Number
- NCT01370460
- Locations
- 🇺🇸
Henry Ford Hospital, Detroit, Michigan, United States
Can we Use Intravenous Injection of Tranexamic Acid in Routine Practice With Active Management of the Third Stage of Labor?
- First Posted Date
- 2011-04-19
- Last Posted Date
- 2011-11-17
- Lead Sponsor
- Erzincan Military Hospital
- Target Recruit Count
- 450
- Registration Number
- NCT01338454
- Locations
- 🇹🇷
Bakıryok Women and Children Hospital, İstanbul, Bakırkoy, Turkey
Tranexamic Acid in Hip Fracture Patients
- First Posted Date
- 2011-03-30
- Last Posted Date
- 2012-06-07
- Lead Sponsor
- Michal Roll PhD,MBA
- Target Recruit Count
- 60
- Registration Number
- NCT01326403
- Locations
- 🇮🇱
Sourasky Medical Center, Tel Aviv, Israel
Fibrin Glue or Tranexamic Acid for Total Knee Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2011-03-01
- Last Posted Date
- 2013-08-28
- Target Recruit Count
- 172
- Registration Number
- NCT01306370
- Locations
- 🇪🇸
Hospital de la Santa Creu i Sant Pau, Barcelona, Catalunya, Spain
Management of Initial Bleeding/Spotting Associated With the Levonorgestrel-releasing Intrauterine System (MIRENA)
- Conditions
- Interventions
- First Posted Date
- 2011-02-14
- Last Posted Date
- 2014-11-04
- Lead Sponsor
- Bayer
- Target Recruit Count
- 187
- Registration Number
- NCT01295294
A Study of Tranexamic Acid (XP12B) in Women With Heavy Menstrual Bleeding
- First Posted Date
- 2011-01-21
- Last Posted Date
- 2011-07-26
- Lead Sponsor
- Ferring Pharmaceuticals
- Target Recruit Count
- 288
- Registration Number
- NCT01280981
- Locations
- 🇺🇸
Clinical Trials of Virginia, INC, Richmond, Virginia, United States
🇺🇸Valley Women's Clinic, Renton, Washington, United States
🇺🇸North Spokane Women's Center, Spokane, Washington, United States
Topical Application of Tranexamic Acid Reduces Postoperative Blood Loss in Total Hip Arthroplasty
- Conditions
- Interventions
- First Posted Date
- 2010-12-15
- Last Posted Date
- 2011-12-01
- Target Recruit Count
- 100
- Registration Number
- NCT01260818
- Locations
- 🇨🇳
the First Affiliated Hospital of Guangzhou TCM University, Guangzhou, Guangdong, China
Impact of Tranexamic Acid on Red Blood Cell Transfusion in Spinal Surgery
- Conditions
- Interventions
- First Posted Date
- 2010-12-10
- Last Posted Date
- 2014-05-01
- Target Recruit Count
- 99
- Registration Number
- NCT01258010
- Locations
- 🇨🇦
Centre Hospitalier de l'Université de Montréal-Hôpital Notre-Dame, Montreal, Quebec, Canada
Comparison of Tranexamic to Epsilon Aminocaproic Acid: a Prospective Analysis of Blood Conservation in Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2010-11-25
- Last Posted Date
- 2020-10-19
- Lead Sponsor
- Loma Linda University
- Target Recruit Count
- 100
- Registration Number
- NCT01248104
- Locations
- 🇺🇸
Loma Linda University Medical Center, Loma Linda, California, United States
Drug Development Updates
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