Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleed...
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Tranexamic Acid and Pediatric Adenotonsillectomy
- Conditions
- Interventions
- First Posted Date
- 2010-10-26
- Last Posted Date
- 2010-12-22
- Target Recruit Count
- 95
- Registration Number
- NCT01228136
- Locations
- 🇧🇷
Hospital da Criança Santo Antônio, Porto Alegre, Rio Grande do Sul, Brazil
Tranexamic Acid in Dacryocystorhinostomy
- Conditions
- Interventions
- First Posted Date
- 2010-10-15
- Last Posted Date
- 2010-10-15
- Lead Sponsor
- HaEmek Medical Center, Israel
- Target Recruit Count
- 80
- Registration Number
- NCT01221909
- Locations
- 🇮🇱
Dept. of Ophthalmology, HaEmek medical center, Afula, Israel
Dose-ranging Study of Tranexamic Acid in Valve Surgery
- First Posted Date
- 2010-08-31
- Last Posted Date
- 2012-11-06
- Target Recruit Count
- 175
- Registration Number
- NCT01191554
- Locations
- 🇨🇳
Cardiovascular Institute and Fuwai Hospital, Beijing, China
Lysteda Pediatric Research Equity Act (PREA) Pharmacokinetic Study in Adolescent Females With Heavy Menstrual Bleeding
- First Posted Date
- 2010-08-27
- Last Posted Date
- 2012-07-16
- Lead Sponsor
- Ferring Pharmaceuticals
- Target Recruit Count
- 20
- Registration Number
- NCT01190150
- Locations
- 🇺🇸
West Coast Clinical Trials, Cypress, California, United States
Tranexamic Acid (TXA) in Pediatric Cardiac Surgery
- First Posted Date
- 2010-06-10
- Last Posted Date
- 2014-07-23
- Lead Sponsor
- Centre Chirurgical Marie Lannelongue
- Target Recruit Count
- 18
- Registration Number
- NCT01141127
- Locations
- 🇫🇷
Centre Chirurgical Marie Lannelongue, Plessis-Robinson, France
Multicenter, Randomized Placebo-controlled Clinical Trial to Evaluate the Effect of Perioperative Use of Tranexamic Acid on Transfusion Requirements and Surgical Bleeding in Major Spine Surgery
- Conditions
- Interventions
- First Posted Date
- 2010-06-03
- Last Posted Date
- 2015-02-24
- Target Recruit Count
- 96
- Registration Number
- NCT01136590
- Locations
- 🇪🇸
Hospital Vall d'Hebron de Barcelona, Barcelona, Spain
🇪🇸Hospital de Getafe, Getafe, Madrid, Spain
🇪🇸Hospital de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain
Intravenous Tranexamic Acid and Intraoperative Visualization During Functional Endoscopic Sinus Surgery
- Conditions
- Interventions
- First Posted Date
- 2010-04-27
- Last Posted Date
- 2012-04-27
- Lead Sponsor
- University of Alberta
- Target Recruit Count
- 28
- Registration Number
- NCT01111669
- Locations
- 🇨🇦
University of Alberta Hospital, Royal Alexandra Hospital, Edmonton, Alberta, Canada
Blood Loss and Transfusion Requirement in Infants Treated With Tranexamic Acid
- First Posted Date
- 2010-03-29
- Last Posted Date
- 2019-07-15
- Lead Sponsor
- The Hospital for Sick Children
- Target Recruit Count
- 90
- Registration Number
- NCT01094977
- Locations
- 🇨🇦
The Hospital for Sick Children, Toronto, Ontario, Canada
The Effect of Tranexamic Acid on Postpartum Hemorrhage During and After Cesarean Delivery
- First Posted Date
- 2010-03-11
- Last Posted Date
- 2011-01-25
- Lead Sponsor
- Tehran University of Medical Sciences
- Target Recruit Count
- 100
- Registration Number
- NCT01085006
- Locations
- 🇮🇷
Laleh Eslamian, Tehran, Iran, Islamic Republic of
The Effect of Tranexamic Acid on Postoperative Blood Loss and Coagulation in Patients With Preoperative Anemia Undergoing Off-Pump Coronary Artery Bypass Graft; Double Blind Randomized Control Study
- First Posted Date
- 2010-02-11
- Last Posted Date
- 2010-12-06
- Lead Sponsor
- Yonsei University
- Target Recruit Count
- 90
- Registration Number
- NCT01067638
- Locations
- 🇰🇷
Yonsei Univ., Seoul, Korea, Republic of
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.