Tranexamic acid
- Generic Name
- Tranexamic acid
- Brand Names
- Cyklokapron, Lysteda
- Drug Type
- Small Molecule
- Chemical Formula
- C8H15NO2
- CAS Number
- 1197-18-8
- Unique Ingredient Identifier
- 6T84R30KC1
- Background
Tranexamic acid is a synthetic derivative of lysine used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to aminocaproic acid but is approximately 10-fold more potent.
It was first patented in 1957 and received its initial US approval in 1986.
- Indication
Taken orally, tranexamic acid is indicated for the treatment of hereditary angioedema, cyclic heavy menstrual bleeding in premenopausal females, and other instances of significant bleeding in the context of hyperfibrinolysis. Given intravenously, tranexamic acid is indicated for short-term use (2-8 days) in patients with hemophilia to prevent or reduce bleed...
- Associated Conditions
- Bleeding, Heavy Menstrual Bleeding, Hereditary Angioedema (HAE)
- Associated Therapies
- -
Tranexamic Acid in Pediatric Undergoing Proximal Femoral Osteotomies and/or Acetabular Osteotomy
- Conditions
- Interventions
- First Posted Date
- 2021-03-23
- Last Posted Date
- 2021-03-23
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 400
- Registration Number
- NCT04811313
This is a Study to Verify if Tranexamic Acid Can Reduce the Anemia After a Femoral Shaft Fractures Surgery
- First Posted Date
- 2021-03-17
- Last Posted Date
- 2021-10-13
- Lead Sponsor
- Christian Candrian
- Registration Number
- NCT04803591
Efficacy of Tranexamic Acid in Upper Gastrointestinal Bleeding
- Conditions
- Interventions
- First Posted Date
- 2021-03-09
- Last Posted Date
- 2021-03-09
- Target Recruit Count
- 160
- Registration Number
- NCT04788121
- Locations
- 🇮🇳
Post Graduate Institute of Medical Education and Research, Chandigarh, India
Tranexamic Acid Versus Adrenaline for Controlling Iatrogenic Endobronchial Bleeding
- Conditions
- Interventions
- First Posted Date
- 2021-02-25
- Last Posted Date
- 2022-02-24
- Lead Sponsor
- Clinical Hospital Centre Zagreb
- Target Recruit Count
- 130
- Registration Number
- NCT04771923
- Locations
- 🇭🇷
Clinical Hospital Centre Zagreb, Zagreb, Croatia
The Effects of Tranexamic Acid or Placebo on Perioperative Bleeding in Adults Undergoing Liver Transplantation.
- First Posted Date
- 2021-02-15
- Last Posted Date
- 2021-08-25
- Lead Sponsor
- Hospital de Clinicas de Porto Alegre
- Target Recruit Count
- 140
- Registration Number
- NCT04753151
- Locations
- 🇧🇷
Andre Prato Schmidt, Porto Alegre, RS, Brazil
Tranexamic Acid and Depot-Medroxyprogesterone Acetate for Perimenopausal Irregular Uterine Bleeding
- Conditions
- Interventions
- First Posted Date
- 2021-01-14
- Last Posted Date
- 2024-04-24
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 110
- Registration Number
- NCT04710017
- Locations
- 🇪🇬
Women Health Hospital - Assiut university, Assiut, Egypt
Comparative Use of Tranexamic Acid Intravenous and Topical Application in Intertrochanteric Fractures With PFNA
- Conditions
- Interventions
- First Posted Date
- 2021-01-06
- Last Posted Date
- 2022-11-04
- Lead Sponsor
- Universidade do Vale do Sapucai
- Target Recruit Count
- 90
- Registration Number
- NCT04696224
- Locations
- 🇧🇷
Hospital das Clinicas Samuel Libanio, Pouso Alegre, MG, Brazil
Effect of Tranexamic Acid on Blood Loss After High Tibial Osteotomy
- Conditions
- Interventions
- First Posted Date
- 2020-12-04
- Last Posted Date
- 2020-12-04
- Lead Sponsor
- The Catholic University of Korea
- Target Recruit Count
- 40
- Registration Number
- NCT04653623
- Locations
- 🇰🇷
The Catholic University of Korea Seoul St Mary's hospital, Seoul, Korea, Republic of
Effect of Prophylactic Tranexamic Acid on Bleeding Outcomes for Dilation and Evacuation
- Conditions
- Interventions
- First Posted Date
- 2020-12-03
- Last Posted Date
- 2023-09-06
- Lead Sponsor
- University of Hawaii
- Target Recruit Count
- 48
- Registration Number
- NCT04651166
- Locations
- 🇺🇸
Queens Medical Center, Honolulu, Hawaii, United States
Tranexamic Acid Versus Misoprostol in Reducing Blood Loss in Cesarean Section in Primigravida
- Conditions
- Interventions
- First Posted Date
- 2020-11-18
- Last Posted Date
- 2022-07-22
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 200
- Registration Number
- NCT04635007
- Locations
- 🇪🇬
faculty of medicine - Cairo university, Cairo, Kasr El Ainy, Egypt
Drug Development Updates
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