Hydroxyethyl Starch
- Generic Name
- Hydroxyethyl Starch
- Brand Names
- Hespan, Hextend, Volulyte, Voluven
- Drug Type
- Small Molecule
- CAS Number
- 9005-27-0
- Unique Ingredient Identifier
- 875Y4127EA
Overview
Hydroxyethyl starch (HES/HAES) is a nonionic starch derivative. Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid resuscitation to replace intravascular volume. HES is a general term and can be sub-classified according to average molecular weight, molar substitution, concentration, C2/C6 ratio and Maximum Daily Dose.
Background
Hydroxyethyl starch (HES/HAES) is a nonionic starch derivative. Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid resuscitation to replace intravascular volume. HES is a general term and can be sub-classified according to average molecular weight, molar substitution, concentration, C2/C6 ratio and Maximum Daily Dose.
Indication
An intravenous solution of hydroxyethyl starch is used to prevent shock following severe blood loss caused by trauma, surgery, or other issues.
Associated Conditions
- Hypovolaemia
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2024/10/29 | Phase 4 | Not yet recruiting | Xiangya Hospital of Central South University | ||
2022/07/27 | Not Applicable | Recruiting | General Hospital of Ningxia Medical University | ||
2022/07/27 | Not Applicable | Completed | General Hospital of Ningxia Medical University | ||
2020/09/28 | N/A | Completed | The George Institute for Global Health, Australia | ||
2018/09/19 | Not Applicable | Completed | Holbaek Sygehus | ||
2018/03/15 | Early Phase 1 | UNKNOWN | |||
2017/11/22 | Phase 4 | Completed | |||
2017/11/09 | Phase 4 | Completed | |||
2017/10/11 | Not Applicable | Completed | |||
2017/09/11 | Phase 4 | Completed |
FDA Approved Products
Product Name | Manufacturer | Route | Strength | Approved | NDC Code |
|---|---|---|---|---|---|
Hextend | INTRAVENOUS | 6 g in 100 mL | 2023/02/15 | 0409-1555 | |
Hetastarch in Sodium Chloride | INTRAVENOUS | 6 g in 100 mL | 2022/07/21 | 0409-7248 | |
6% HETASTARCH IN 0.9% SODIUM CHLORIDE | HF Acquisition Co LLC, DBA HealthFirst | INTRAVENOUS | 6 g in 100 mL | 2024/01/29 | 51662-1317 |
EMA Approved Products
Medicine Name | EMA Number | Auth. Holder | Country | Drug Type | Status | Issued | Opinion | Revision |
|---|
No EMA products found
No EMA products found for this drug
Singapore Approved Products
Product Name | Manufacturer | Dosage Form | Strength | Approved | Approval No. |
|---|---|---|---|---|---|
VOLUVEN SOLUTION FOR INFUSION 6% | INJECTION | 60 g/l | 2003/05/16 | SIN12297P |
China Approved Products
Product Name | Approval No. | Manufacturer | Dosage Form | Trade Name | Strength | Type | Status | Date | Import |
|---|---|---|---|---|---|---|---|---|---|
Hydroxyethyl Starch 20 Sodium Chloride Injection | 国药准字H20023029 | N/A | N/A | 500ml:30g羟乙基淀粉20与4.5g氯化钠 | Chemical Drug | Approved | 2010/09/30 | Domestic | |
Hydroxyethyl Starch 20 Sodium Chloride Injection | 国药准字H20033771 | 注射剂 | N/A | 500ml:30g的羟乙基淀粉20与氯化钠4.5g | Chemical Drug | Approved | 2020/07/23 | Domestic | |
Hydroxyethyl Starch 20 Sodium Chloride Injection | 国药准字H37023644 | 注射剂 | N/A | 500ml:30g羟乙基淀粉20与氯化钠4.5g | Chemical Drug | Approved | 2020/06/30 | Domestic | |
Hydroxyethyl Starch 20 Sodium Chloride Injection | 国药准字H20013073 | 注射剂 | N/A | 250ml:15g羟乙基淀粉20与氯化钠2.25g | Chemical Drug | Approved | 2020/06/30 | Domestic | |
Hydroxyethyl Starch 20 Sodium Chloride Injection | 国药准字H37021515 | 注射剂 | N/A | 500ml:30g羟乙基淀粉20与4.5g氯化钠 | Chemical Drug | Approved | 2015/10/29 | Domestic | |
Hydroxyethyl Starch 20 Sodium Chloride Injection | 国药准字H19999409 | 注射剂 | N/A | 500ml:30g羟乙基淀粉20与氯化钠4.5g | Chemical Drug | Approved | 2020/09/10 | Domestic | |
HydroxyethylStarch 20 SodiumChloride Injection | 国药准字H61023086 | N/A | N/A | 500ml:30g羟乙基淀粉20与氯化钠4.5g | Chemical Drug | Approved | 2003/04/18 | Domestic | |
Hydroxyethyl Starch 20 Sodium Chloride Injection | 国药准字H15021423 | 注射剂 | N/A | 250ml:15g羟乙基淀粉20与氯化钠2.25g | Chemical Drug | Approved | 2016/03/30 | Domestic | |
Hydroxyethyl Starch 20 Sodium Chloride Injection | 国药准字H20033770 | 注射剂 | N/A | 250ml:15g的羟乙基淀粉20与氯化钠2.25g | Chemical Drug | Approved | 2020/07/23 | Domestic | |
HydroxyethylStarch 20 SodiumChloride Injection | 国药准字H32020977 | 注射剂 | N/A | 500ml:30g的羟乙基淀粉20,氯化钠4.5g | Chemical Drug | Approved | 2020/07/30 | Domestic |
Australia Approved Products
Product Name | ARTG ID | Sponsor | Status | Reg. Date | Ingredient |
|---|---|---|---|---|---|
VOLUVEN 6% hydroxyethyl starch 130/0.4 250 mL solution for intravenous infusion bag | 120359 | Fresenius Kabi Australia Pty Ltd | Active | 2006/11/13 | hydroxyethyl starch 130/0.4 |
VOLUVEN 6% hydroxyethyl starch 130/0.4 500 mL solution for intravenous infusion bag | 120361 | Fresenius Kabi Australia Pty Ltd | Active | 2006/11/13 | hydroxyethyl starch 130/0.4 |