Hydroxyethyl Starch
- Generic Name
- Hydroxyethyl Starch
- Brand Names
- Hespan, Hextend, Volulyte, Voluven
- Drug Type
- Small Molecule
- CAS Number
- 9005-27-0
- Unique Ingredient Identifier
- 875Y4127EA
- Background
Hydroxyethyl starch (HES/HAES) is a nonionic starch derivative. Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid resuscitation to replace intravascular volume.
HES is a general term and can be sub-classified according to average molecular weight, molar substitution, concentration, C2/C6 ratio and Maximum Daily Dose.
- Indication
An intravenous solution of hydroxyethyl starch is used to prevent shock following severe blood loss caused by trauma, surgery, or other issues.
- Associated Conditions
- Hypovolaemia
- Associated Therapies
- Granulocyte yield increase
Hydroxyethyl Starch 130/0.4 and Sodium Chloride Injection as Adjunctive Therapy in Subjects With Internal Carotid Artery Hypoperfusion
- Conditions
- Brain Hypoperfusion
- Interventions
- First Posted Date
- 2010-09-01
- Last Posted Date
- 2010-11-01
- Lead Sponsor
- Xijing Hospital
- Target Recruit Count
- 120
- Registration Number
- NCT01192581
- Locations
- 🇨🇳
Department of Neurology , Xijing Hospital, Xi'an, Shaanxi, China
Plasma Volume Replacement (PVR) Therapy With Colloid and Crystalloid Solutions
- Conditions
- Surgery of the Pancreatic HeadPlasma Volume Replacement
- Interventions
- First Posted Date
- 2010-05-05
- Last Posted Date
- 2016-12-23
- Lead Sponsor
- B. Braun Melsungen AG
- Target Recruit Count
- 63
- Registration Number
- NCT01117649
- Locations
- 🇩🇪
Klinik für Anästhesie und operative Intensivmedizin, Charité-Universitätsmedizin Berlin, Berlin, Germany
🇩🇪Klinik für Anästhesie, operative Intensivmedizin und Schmerztherapie, Humboldt Klinikum, Berlin, Germany
🇩🇪Universitätsklinikum Bonn, Bonn, Germany
Early Fluid Resuscitation With Balanced HES 130/0.4 [6%] in Severe Burn Injury
- Conditions
- Burns
- First Posted Date
- 2009-11-13
- Last Posted Date
- 2011-03-16
- Lead Sponsor
- University of Zurich
- Target Recruit Count
- 48
- Registration Number
- NCT01012648
- Locations
- 🇨🇭
Surgical ICU, Zurich, Switzerland
Use of Hextend in Trauma
- First Posted Date
- 2009-09-24
- Last Posted Date
- 2017-06-14
- Lead Sponsor
- University of Miami
- Target Recruit Count
- 1714
- Registration Number
- NCT00983281
- Locations
- 🇺🇸
University of Miami, Miami, Florida, United States
Tetraspan 6 Percent (%) Combined With Sterofundin ISO Versus Albumin 5 Percent (%) Combined With Sodium Chloride (NaCL)
- Conditions
- Renal Insufficiency
- Interventions
- Drug: Albumin + electrolyte solution
- First Posted Date
- 2009-07-09
- Last Posted Date
- 2010-09-28
- Lead Sponsor
- B. Braun Melsungen AG
- Target Recruit Count
- 2
- Registration Number
- NCT00936247
- Locations
- 🇩🇪
Klinik für Anästhesiologie und operative Intensivmedizin, Klinikum der Stadt Ludwigshafen, Ludwigshafen, Germany
🇩🇪Klinikum Mannheim gGmbH, Klinik für Anästhesiologie und Operative Intensivmedizin, Mannheim, Germany
Voluven® in Paediatric Patients
- Conditions
- Cardiac SurgeryCardiopulmonary Bypass
- Interventions
- Drug: Human serum albumin (HSA 50g/L)
- First Posted Date
- 2009-03-12
- Last Posted Date
- 2011-11-02
- Lead Sponsor
- Fresenius Kabi
- Target Recruit Count
- 61
- Registration Number
- NCT00860405
- Locations
- 🇦🇹
AKh Allgemeines Krankenhaus der Stadt Linz GmbH, Linz, Austria
🇧🇪HUDERF - Hôpital Universitaire des Enfants Reine Fabiola, Brussels, Belgium
Non-Interventional (Observational) Post-Authorization Safety Study of HES 130/0.42 in Paediatric Patients
- First Posted Date
- 2008-12-11
- Last Posted Date
- 2009-05-19
- Lead Sponsor
- B. Braun Melsungen AG
- Target Recruit Count
- 1130
- Registration Number
- NCT00806533
- Locations
- 🇨🇿
Clinic of Children's Anaesthesiology and Resuscitation, Brno, Czech Republic
🇦🇹Donauspital SMZ-OST, Vienna, Austria
🇨🇿Clinic of Anaesthesiology and Resuscitation, Praha, Czech Republic
Effect of Prime Solution on Fluid Balance After Open Heart Surgery
- Conditions
- Valve SurgeryCoronary Artery Bypass Grafting
- Interventions
- Drug: Ringer lactate
- First Posted Date
- 2008-11-25
- Last Posted Date
- 2015-08-25
- Lead Sponsor
- University of Helsinki
- Target Recruit Count
- 35
- Registration Number
- NCT00797589
- Locations
- 🇫🇮
Helsinki University Central Hospital, Helsinki, Finland
Comparative Evaluation of Albumin and Starch Effects in Acute Lung Injury (ALI)
- Conditions
- Lung Injury, Acute (ALI)Respiratory Distress Syndrome, Acute (ARDS)
- Interventions
- Drug: 5% human albumin
- First Posted Date
- 2008-11-24
- Last Posted Date
- 2017-04-28
- Lead Sponsor
- Emory University
- Target Recruit Count
- 31
- Registration Number
- NCT00796419
- Locations
- 🇺🇸
Emory Crawford Long Hospital, Atlanta, Georgia, United States
🇺🇸Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, United States
🇺🇸Grady Memorial Hospital, Atlanta, Georgia, United States
Efficacy of Voluven® for the Prevention of Hypotension During Spinal Anesthesia for Cesarean Section
- Conditions
- Hypotension
- Interventions
- Drug: Ringer's Lactate solution
- First Posted Date
- 2008-06-10
- Last Posted Date
- 2012-05-31
- Lead Sponsor
- Fresenius Kabi
- Target Recruit Count
- 167
- Registration Number
- NCT00694343
- Locations
- 🇫🇷
CHU Hotel Dieu, Service Anesthesie, Lyon, France
🇫🇷Höpital Louis-Mourier - Service d'Anesthesie, Colombes, France
🇫🇷CHU Clermont Ferrand - Hotel Dieu, Service Anesthesie-Reanimation, Clermont Ferrand, France
Drug Development Updates
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