Lycopene

Generic Name: Lycopene

Drug Type: Small Molecule

Chemical Formula: C_₄₀H_₅₆

CAS Number: 502-65-8

Unique Ingredient Identifier: SB0N2N0WV6

Background: Lycopene is a naturally occuring red carotenoid pigment that is responsible in red to pink colors seen in tomatoes, pink grapefruit, and other foods . Having a chemical formula of C40H56, lycopene is a tetraterpene assembled from eight isoprene units that are solely composed of carbon and hydrogen. Lycophene may undergo extensive isomerization that allows 1056 theoretical cis-trans configurations; however the all-trans configuration of lycopene is the most predominant isomer found in foods that gives the red hue. Lycopene is a non-essential human nutrient that is classified as a non-provitamin A carotenoid pigment since it lacks a terminal beta ionone ring and does not mediate vitamin A activity. However lycophene is a potent antioxidant molecule that scavenges reactive oxygen species (ROS) singlet oxygen. Tomato lycopene extract is used as a color additive in food products.

Indication: Not Available

Associated Therapies: Nutritional supplementation

Clinical Trials

Evaluation of Lycopene in the Treatment of Erosive Oral Lichen Planus

Phase 2

Completed

Conditions: Erosive Lichen Planus

Interventions: Drug: Lycopene Softgel, 10 Mg
Drug: Prednisolone

First Posted Date: 2020-12-03

Last Posted Date: 2020-12-03

Lead Sponsor: Nourhan M.Aly

Target Recruit Count: 20

Registration Number: NCT04652739

Locations: 🇪🇬
Faculty of Dentistry, Alexandria University, Alexandria, Egypt

Lycopene vs Minocycline Hydrochloride as Adjunctive to Periodontal Treatment

Phase 2

Conditions: Periodontal Pocket

Interventions: Other: Distilled water
Drug: Minocycline HCl 1mg Oral Powder
Drug: Lycopene

First Posted Date: 2019-05-28

Last Posted Date: 2019-05-28

Lead Sponsor: University of Baghdad

Target Recruit Count: 30

Registration Number: NCT03964935

Locations: 🇮🇶
College of Dentistry/ University of Baghdad, Baghdad, Iraq

Gingival Crevicular Fluid Levels of Protein Carbonyl Following the Use of Lycopene in Chronic Periodontitis

Phase 1

Completed

Conditions: Chronic Periodontitis

Interventions: Drug: Lycopene + SRP
Procedure: SRP only

First Posted Date: 2017-06-29

Last Posted Date: 2017-06-29

Lead Sponsor: Maie Sami tawfik

Target Recruit Count: 24

Registration Number: NCT03203746

Panitumumab Skin Toxicity Prevention Trial

Phase 2

Conditions: Skin Toxicity
Colorectal Cancer Metastatic

Interventions: Drug: Lycopene
Other: Placebo

First Posted Date: 2017-05-25

Last Posted Date: 2021-09-09

Lead Sponsor: Ospedale San Carlo Borromeo

Target Recruit Count: 28

Registration Number: NCT03167268

Locations: 🇮🇹
Marco Pirovano, Milano, Italy

A Clinical Trial to Study the Effects of Two Drugs, Lycopene and Prednisolone in Patients With Oral Lichen Planus

Phase 4

Completed

Conditions: Oral Lichen Planus

Interventions: Drug: Prednisolone
Drug: lycopene

First Posted Date: 2015-10-27

Last Posted Date: 2016-02-26

Lead Sponsor: B.P. Koirala Institute of Health Sciences

Target Recruit Count: 28

Registration Number: NCT02587117

Docetaxel and Lycopene in Metastatic Prostate Cancer

Phase 1

Completed

Conditions: Adenocarcinoma of the Prostate

Interventions: Drug: Lycopene and Docetaxel

First Posted Date: 2013-09-24

Last Posted Date: 2018-01-11

Lead Sponsor: Medical University of South Carolina

Target Recruit Count: 24

Registration Number: NCT01949519

Locations: 🇺🇸
Medical University of South Carolina, Charleston, South Carolina, United States
🇺🇸
Ralph H. Johnson Veterans Administration Medical Center, Charleston, South Carolina, United States