Novadel pharma inc, Pohl boskamp, Graceway pharmaceuticals llc, Key pharmaceuticals inc sub schering plough corp, Hercon laboratories corp, Kremers urban co, Mylan technologies inc, Novartis pharmaceuticals corp, G pohl boskamp gmbh and co, Sanofi aventis us llc, Abraxis pharmaceutical products, Hospira inc, International medication systems ltd, Luitpold pharmaceuticals inc, Smith and nephew solopak div smith and nephew, Baxter healthcare corp, Rorer pharmaceutical corp sub rorer group, Parke davis div warner lambert co, E fougera div altana inc, Pfizer pharmaceuticals ltd • Sublingual nitroglycerin is indicated for the acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease. Transdermal nitroglycerin is indicated for the prevention of angina pectoris due to coronary artery disease. Intravenous nitroglycerin is indicated for the treatment of peri-operative hypertension; for control of congestive heart failure in the setting of acute myocardial infarction; for treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and beta (β)-blockers; and for induction of intraoperative hypotension. Topical nitroglycerin ointment is used to treat moderate to severe pain associated with chronic anal fissure.
Nitroglycerin is a nitrate vasodilator used to treat or prevent angina, heart failure, hypertension, and anal fissures.
Nitroglycerin is converted by mitochondrial aldehyde dehydrogenase in smooth muscle cells to nitric oxide (NO), a potent vasodilator. NO activates the enzyme guanylate cyclase, which converts guanosine triphosphate (GTP) to cyclic guanosine 3',5'-monophosphate (cGMP) in vascular smooth muscle and other tissues. cGMP is an endogenous vasodilator of vascular smooth muscle: it causes protein kinase-dependent phosphorylation and activates downstream cascades that promote relaxation and increased blood flow in veins, arteries and cardiac tissue. An in vitro study using mouse aorta suggests that nitric oxide, an active metabolite of nitroglycerin, targets the natriuretic peptide receptors.
