Manufacturers: Hospira inc, Bedford laboratories
Pentostatin is an adenosine deaminase inhibitor used to treat hairy cell leukemia.
Pentostatin is an adenosine deaminase inhibitor used to treat hairy cell leukemia.
Pentostatin is a potent transition state inhibitor of adenosine deaminase (ADA), the greatest activity of which is found in cells of the lymphoid system. T-cells have higher ADA activity than B-cells, and T-cell malignancies have higher activity than B-cell malignancies. The cytotoxicity that results from prevention of catabolism of adenosine or deoxyadenosine is thought to be due to elevated intracellular levels of dATP, which can block DNA synthesis through inhibition of ribonucleotide reductase. Intracellular activation results in incorporation into DNA as a false purine base. An additional cytotoxic effect is related to its incorporation into RNA. Cytotoxicity is cell cycle phase-specific (S-phase).
For the treatment of hairy cell leukaemia refractory to alpha interferon.
7 associated conditions
One entry per invention. Patent families filed in the US, EP, WO and CN offices.
