Plantago seed

Generic Name: Plantago seed

Brand Names: Konsyl, Metamucil, Reguloid

Drug Type: Biotech

CAS Number: 8063-16-9

Unique Ingredient Identifier: 9C60Y73166

Background: Platango seeds refer to the seeds collected from various species of plantago trees. It is found in some laxatives for treating occasional constipation and restoring regularity in bowel movements. Its potential benefit in maintaining remission in ulcerative colitis has been studied .

Regardless, this agent is most predominantly used as a gentle laxative agent in many parts of the world that is more commonly referred as psyllium or psyllium husk.

Indication: Indications include the treatment of patients needing a high fibre regime, perhaps for: (a) the relief of constipation, including constipation in pregnancy and the maintenance of regularity; (b) the management of bowel function in patients with colostomy, ileostomy, hemorrhoids, anal fissure, chronic diarrhea with diverticular disease, irritable bowel syndrome, and ulcerative colitis .

Associated Conditions: Bowel Motility, Constipation

Clinical Trials

Psyllium in Pediatric IBS

Phase 3

Recruiting

Conditions: Irritable Bowel Syndrome

Interventions: Drug: Psyllium (0.5 g/year of age per day)
Drug: Psyllium (0.7 g/year of age per day)
Drug: Placebo
Other: fructans

First Posted Date: 2024-10-15

Last Posted Date: 2025-04-03

Lead Sponsor: Dr Bruno Chumpitazi, M.D.

Target Recruit Count: 110

Registration Number: NCT06639984

Locations: 🇺🇸
Duke University, Durham, North Carolina, United States

The Safety and Efficacy of 5-HT3 Receptor Antagonist (Ramosetron) for the Treatment of Fecal Incontinence

Phase 2

Not yet recruiting

Conditions: Fecal Incontinence

Interventions: Drug: Psyllium
Drug: Ramosetron

First Posted Date: 2023-12-12

Last Posted Date: 2023-12-12

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 148

Registration Number: NCT06166615

To Compare the Efficacy of Drugs in Combination for Treating Irritable Bowel Syndrome Associated With Diarrhea

Phase 4

Completed

Conditions: Irritable Bowel Syndrome With Diarrhea

Interventions: Drug: Rifaximin 550 MG
Drug: Psyllium Husk
Drug: Mebeverine 135 MG
Drug: Amitriptyline Hydrochloride 25 MG

First Posted Date: 2023-05-22

Last Posted Date: 2023-07-27

Lead Sponsor: Bahria University

Target Recruit Count: 162

Registration Number: NCT05867550

Locations: 🇵🇰
Bahria University Health Sciences Campus, Karachi, Sindh, Pakistan

Tolerance & Responsiveness Improvement for Metformin (TRIM)

Phase 4

Completed

Conditions: Type2 Diabetes Mellitus

Interventions: Drug: Metformin Extended Release Oral Tablet
Drug: Psyllium powder

First Posted Date: 2018-09-13

Last Posted Date: 2021-09-10

Lead Sponsor: West Side Institute for Science and Education

Target Recruit Count: 29

Registration Number: NCT03670043

Locations: 🇺🇸
Jesse Brown VA Medical Center, Chicago, Illinois, United States

Comparison of Taste and Palatability in Fiber Supplements

Not Applicable

Completed

Conditions: Constipation

Interventions: Drug: Volcolon sugar free
Drug: Metamucil Orange
Drug: Psyllium Orange

First Posted Date: 2016-08-16

Last Posted Date: 2017-11-06

Lead Sponsor: Amsterdam UMC, location VUmc

Target Recruit Count: 100

Registration Number: NCT02867917

Use of Novel Prebiotic Fiber for Targeted Dietary Management of Irritable Bowel Syndrome (Nutrabiotix Phase II)

Phase 2

Terminated

Conditions: Constipation-predominant IBS (IBS-C)

Interventions: Dietary Supplement: NTX-1
Drug: psyllium (15 g)

First Posted Date: 2014-05-22

Last Posted Date: 2016-05-02

Lead Sponsor: Nutrabiotix, LLC

Target Recruit Count: 120

Registration Number: NCT02144753

Locations: 🇺🇸
Rush University Medical Center, Chicago, Illinois, United States

Psyllium Fiber Versus Placebo in Early Treatment After STARR for Obstructed Defecation: a Double-blind RCT

Phase 4

Completed

Conditions: Constipation
Incontinence

Interventions: Drug: Placebo
Drug: Psyllium fiber

First Posted Date: 2014-05-13

Last Posted Date: 2014-05-13

Lead Sponsor: Francesco Gabrielli

Target Recruit Count: 65

Registration Number: NCT02136693

Locations: 🇮🇹
Istituti Clinici Zucchi, Monza, MB, Italy

Cholesterol Lowering Treatment With Psyllium Husks and Isolated Soy Protein in Hypercholesterolemia

Phase 4

Completed

Conditions: Hypercholesterolemia

Interventions: Drug: Psyllium husks
Dietary Supplement: Isolated soy protein
Dietary Supplement: Isolated whey protein
Other: Microcrystalline cellulose

First Posted Date: 2010-12-02

Last Posted Date: 2014-01-29

Lead Sponsor: Aalborg University Hospital

Target Recruit Count: 41

Registration Number: NCT01251991

Locations: 🇩🇰
The Lipid Clinic, Aalborg Hospital, Aalborg, RN, Denmark

Efficacy and Mechanisms of Pharmacologic Treatment of Fecal Incontinence

Phase 2

Completed

Conditions: Fecal Incontinence

Interventions: Drug: Psyllium powder
Drug: Loperamide

First Posted Date: 2008-08-04

Last Posted Date: 2015-04-01

Lead Sponsor: US Department of Veterans Affairs

Target Recruit Count: 80

Registration Number: NCT00727649

Locations: 🇺🇸
VA Medical Center, Birmingham, Birmingham, Alabama, United States

Dietary Interventions in Irritable Bowel Syndrome: Soluble, Insoluble or no Fibre?

Not Applicable

Completed

Conditions: Colonic Diseases, Functional

First Posted Date: 2005-09-16

Last Posted Date: 2007-04-20

Lead Sponsor: UMC Utrecht

Target Recruit Count: 285

Registration Number: NCT00189033

Locations: 🇳🇱
University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Department of General Practice, Utrecht, Netherlands
🇳🇱
University of Maastricht, CAPHRI institute, Department of General Practice, Maastricht, Netherlands

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